事关帕金森病治疗，我国科学家获得突破性成果！

Core Insights - Chinese scientists have discovered the underlying functional network mechanism of Parkinson's disease for the first time in the world, which has shown promising results in clinical research [1][2][4]. Group 1: Discovery and Mechanism - Parkinson's disease is a common neurodegenerative disorder characterized by tremors, bradykinesia, and muscle rigidity, presenting significant treatment challenges [2]. - The core issue identified is a severe functional abnormality in a key brain network known as the somatic cognitive network, which is crucial for action planning and coordination [2][4]. - Analysis of over 800 human brain imaging data revealed that the somatic cognitive network has tight connections with several deep brain nuclei, which exhibit pathological enhancement in patients, leading to various complex symptoms [2]. Group 2: Treatment Development - The discovery of this network provides new insights into potential treatment targets and could lead to novel therapeutic approaches [4]. - The research team has developed a new generation of precise brain circuit stimulation systems, achieving accurate targeting and non-invasive treatment for Parkinson's disease, which has received national medical device registration [5]. - Clinical results indicate that after two weeks of treatment, the efficacy rate for the somatic cognitive target group reached 55.5%, compared to 22.2% for traditional stimulation of the motor cortex [5]. Group 3: Collaborative Efforts - The research was led by Changping Laboratory in collaboration with over ten domestic and international institutions, including Peking University and Tsinghua University [6]. - The director of Changping Laboratory emphasized the aim to develop foundational technologies to address major national needs and hopes for the rapid clinical application of this breakthrough to benefit more patients [6].