超声血栓切除技术再获资本加注，赛道商业化加速

Core Insights - SonoVascular has developed an innovative system called SonoThrombectomy for thrombus removal, utilizing ultrasound energy, microbubbles, and low-dose thrombolytic drugs [3][4][19] - The company recently completed a $6 million Series A funding round, led by Harbright Ventures, with Robert Ross joining the board [1][19] - The technology aims to address significant health threats posed by deep vein thrombosis (DVT) and pulmonary embolism, which affect approximately 900,000 patients annually in the U.S. [6][19] Company Overview - SonoVascular's SonoThrombectomy system integrates ultrasound-mediated microbubble delivery, low-dose thrombolytic infusion, and mechanical thrombus retrieval, designed to minimize damage to blood vessels while effectively dissolving clots [3][4][19] - The system has shown promising results in preclinical studies, with a fourfold increase in thrombolytic drug penetration depth compared to controls, and a significant reduction in drug dosage without loss of efficacy [3][4][19] Clinical Progress - Initial human clinical trials in South America demonstrated 100% thrombus reduction in 10 patients, with no serious device-related adverse events reported [4][19] - Follow-up assessments at six months indicated significant improvements in symptoms and clinical scores related to post-thrombotic syndrome [4][19] Market Context - The current clinical guidelines recommend various management strategies for DVT, highlighting a gap in effective treatment options, particularly for proximal DVT [6][19] - SonoVascular aims to fill this gap by obtaining FDA approval for pivotal studies and initiating human trials for pulmonary embolism treatment, targeting a condition with a mortality rate of 10%-30% [6][19] Competitive Landscape - The technology represents a shift in thrombus management standards, potentially reducing blood loss and vascular trauma during treatment [20][26] - In contrast, Medtronic's Liberant system, which has already been commercialized, focuses on real-time adjustments to suction frequency to minimize blood loss during procedures [22][23][26] - Both systems share ultrasound technology but differ in their approaches, with SonoVascular emphasizing microbubble-mediated effects and Medtronic focusing on intelligent suction control [26][27]