打通生物制造技术产业化全链条——记科技进步特等奖多酶协同催化体系及生物基产品绿色制造技术创新与产业化

Core Viewpoint - The article emphasizes the importance of transforming academic research into industrial applications, highlighting the achievements of Professor Wei Dongzhi and his team in the field of biomanufacturing, which has led to significant advancements in green manufacturing technologies and large-scale production of bio-based products [1] Group 1: Biomanufacturing Technology Development - Biomanufacturing is a global competitive focus that aligns with China's strategy to become a manufacturing powerhouse, transitioning traditional chemical industries towards biomanufacturing [1] - The team has developed multi-enzyme synergistic catalysis systems and green manufacturing technologies, enabling large-scale production in food, chemical, pharmaceutical, and pesticide sectors [1] Group 2: Enzyme Discovery and Modification - The team has created a rapid, precise, and efficient industrial enzyme customization technology, enhancing enzyme activity to address core challenges in biocatalysis [2] - A self-controlled enzyme and microorganism resource library has been established, containing over ten thousand physical enzymes and over one hundred million virtual enzymes, significantly improving the efficiency and precision of enzyme discovery [2] Group 3: Multi-Enzyme Synergistic Catalysis - The team has developed multi-enzyme cascade biocatalysis technology, addressing the compatibility and efficiency issues of multi-enzyme systems by unifying enzyme properties and optimizing reaction conditions [4] - A novel method for enzyme self-assembly has been introduced, incorporating mass transfer theories from chemical engineering, which has halved conversion time and achieved over 99% conversion rates [4] Group 4: Green and Clean Production - The team has innovated low-cost, large-scale, and clean production technologies for biocatalysis, overcoming challenges related to complex media, high production costs, and difficult post-processing [5] - A buffer-free biocatalytic reaction system has been created, allowing enzymes to catalyze reactions directly in pure water, simplifying processes and achieving cleaner production [6] Group 5: Future Directions - The team plans to explore new multidimensional development paths, focusing on the integration of artificial intelligence with biotechnology, and continuing to enhance the industrialization of biomanufacturing [7]