全球首个！千万级免疫细胞图谱成功绘制，有望提供未来治疗方案

Core Viewpoint - A significant breakthrough in immunology has been achieved with the creation of a high-resolution immune multi-omics map (CIMA) based on over 10 million peripheral blood immune cells from the Chinese population, marking the first global immune cell map at this scale [3][4]. Group 1: Research Achievements - The research team, led by the Shenzhen BGI Life Sciences Institute, has established detailed "identities" for each immune cell type, documenting their distribution and gene expression characteristics [3]. - The study integrates data from 154 molecular and disease traits, identifying 1,196 significant genetic associations across 68 immune cell types, with 73.2% of these associations being specific to certain cell types [4]. Group 2: Implications for Disease Understanding - The findings allow researchers to understand not only which genetic variants are associated with diseases but also how these variants operate within specific immune cell types, influencing gene expression and disease risk [4]. - For instance, the research elucidates how a key variant regulates gene expression in specific regulatory T cells, affecting inflammation levels and increasing asthma risk, thus providing insights for future precision treatment strategies [4]. Group 3: Contribution to Global Immunology - This "panoramic" resource achieves international leadership in scale and resolution, providing a systematic and high-resolution foundation for studying disease susceptibility, immune aging, and population differences, particularly for East Asian populations [4].