AstraZeneca’s growth engine stays on track despite cost pressures

Core Insights - AstraZeneca PLC demonstrated strong operational performance in a challenging comparison period, with a commitment to long-term growth [1] - The company reported fourth-quarter revenue of $15.5 billion, exceeding consensus by just over 1% [1] Financial Performance - Core earnings per share were $2.12, with underlying earnings growth estimated at 16% for the year after excluding non-repeating collaboration revenue [2] - Oncology sales increased by 19% to $6.47 billion, driven by strong contributions from Imfinzi and Calquence [2] - Cardiovascular, renal, and metabolism (CVRM) sales also exceeded forecasts, although Farxiga is expected to face generic competition starting in Q2 2026 [3] Expenses and Profitability - Core operating profit fell short of consensus by 8% due to higher-than-expected R&D and SG&A expenses, with R&D accounting for 24% of total revenue [4] - The company is investing in late-stage trials and next-generation technologies, including GLP-1s and bispecifics [4] Future Guidance - AstraZeneca provided guidance for mid- to high-single-digit revenue growth in 2026 and low double-digit EPS growth, both at constant exchange rates [4] - ShoreCap's forecast for 2026 includes 11% revenue growth and 19% EPS growth, which may be revised due to higher finance costs [5] Long-term Ambitions - AstraZeneca aims to achieve $80 billion in annual revenue by 2030, with projections suggesting this target may be beatable at $82 billion [5] Valuation - The stock trades at a forward price-to-earnings ratio of 18–19 times for 2026, a premium to peers, justified by a strong pipeline and multiple phase III catalysts expected [6] - Following a sluggish start, shares increased by 1% to 14,044p [6]