STRATA Skin Sciences Highlights Meta-Analysis Confirming Clinical Efficacy of 308 nm Excimer Laser for Plaque Psoriasis

Core Insights - The February 2026 meta-analysis confirms the clinical efficacy of 308 nm Excimer laser therapy for plaque psoriasis, highlighting its effectiveness in reducing PASI scores significantly [1][11] Clinical Efficacy - The systematic review and meta-analysis published in the Journal of Drugs in Dermatology evaluated clinical trials that demonstrated substantial reductions in PASI scores, with patients typically achieving these outcomes within 10–14 treatments over approximately 5–7 weeks [1][3][8] - Specific studies reported significant PASI improvements: Tang et al. showed a reduction from 11.47 to 5.08 (~56%), He et al. from 14.73 to 2.42 (~84%), Gerber et al. from 13.70 to 2.10 (~85%), and Dong et al. from 12.02 to 4.09 (~66%) [9] Treatment Protocols - The analysis emphasized the importance of MED-guided dosing, which calibrates the lowest UVB fluence producing visible erythema at 24 hours, allowing for targeted treatment [4] - Treatment fluences across studies ranged from approximately 200–600 mJ/cm² per session (1–3× MED), with some protocols using up to 1,200 mJ/cm² total fluence per session, indicating a higher energy level compared to conventional UVB phototherapy [5][6] Technological Advancements - STRATA's high-power XTRAC® technology models facilitate the delivery of optimized targeted doses efficiently, supporting shorter treatment times while maintaining favorable practice economics [7] Industry Commitment - STRATA Skin Sciences is dedicated to advancing clinical evidence-based dermatologic therapies, focusing on improving outcomes for patients with chronic inflammatory skin diseases [11][12]