打造消灭癌细胞的“超级守护者”，中国科学家最新成果为癌症免疫疗法提供新思路

Group 1 - The research team from the Chinese Academy of Sciences has developed a method called "histidine scanning" to enhance the sensitivity of T cell receptors (TCRs) in identifying and eliminating cancer cells [1][3] - The modified TCRs act as high-sensitivity "security checks," significantly improving T cells' ability to clear cancer cells, as demonstrated in mouse experiments [1][3] - This method does not rely on the three-dimensional structural information of TCRs, allowing for simultaneous modification of multiple "key points" to enhance their ability to capture cancer cells [1][2] Group 2 - The study provides a new approach for developing a next-generation, efficient, and precise cancer immunotherapy, showing significant efficacy in animal models [3]