昆医大附一院创全球异种移植存活纪录

Core Viewpoint - The successful transplantation of a six-gene edited pig liver and kidney into a human subject marks a significant milestone in xenotransplantation, achieving the longest survival time of 11 days for such organs in a human body [1][2]. Group 1: Transplant Procedure and Results - The transplantation procedure lasted 10 hours, involving the removal of the recipient's left liver lobe and the precise reconstruction of blood vessels to ensure proper blood flow to the transplanted organs [1]. - The transplanted liver demonstrated stable bile secretion, with an average daily bile output exceeding 150 milliliters, peaking at over 200 milliliters, which is close to normal physiological levels [1][2]. - The kidney transplant showed immediate functionality, with a total urine output exceeding 4000 milliliters during the observation period, and a single-day maximum of over 1800 milliliters, indicating normal physiological function [1][2]. Group 2: Genetic Engineering and Ethical Considerations - The donor pig was bred in China and met DPF (Disease-Free Pig) biosecurity standards, utilizing gene editing to knock out three pig antigen genes and introduce two human complement regulatory protein genes and one human coagulation regulatory protein gene [2]. - The study underwent strict ethical review, and the research was terminated at the request of the subject's family on the 11th day [2]. - This research aligns closely with clinical applications, as it allows for the pig liver to temporarily replace the function of a failing liver, providing time for the patient's own liver to regenerate or for a human donor liver to become available [2]. Group 3: Implications for Future Research - This breakthrough provides valuable data to address the global organ shortage issue through xenotransplantation, laying a solid foundation for future clinical research [2].