多酶协同催化体系变身生物制造“魔法钥匙”

Core Viewpoint - The article highlights the innovative biomanufacturing technology developed by Professor Wei Dongzhi's team at East China University of Science and Technology, which allows for the production of high-purity squalene through genetically modified yeast, significantly reducing reliance on shark extraction methods [1][2]. Group 1: Biomanufacturing Technology - The new squalene manufacturing process can replace the extraction of 3,000 sharks with a single fermentation tank capable of producing 20 tons [1]. - The "multi-enzyme cooperative catalysis system" developed by the team has enabled the biomanufacturing of over 20 pharmaceutical and chemical products, serving as a "toolbox" for biobased product manufacturing [1][2]. - The team has created a large enzyme library with over 10,000 proprietary enzymes, facilitating efficient biomanufacturing processes [3]. Group 2: Technical Innovations - The team has developed a multi-enzyme cascade biocatalysis technology that allows different enzymes to work efficiently together, akin to building blocks with interlocking features [2]. - A significant breakthrough was achieved in the biomanufacturing of the herbicide L-phosphinothricin, with a production line capable of producing 10,000 tons annually, breaking foreign technology monopolies [6]. - The production line boasts nearly 100% raw material utilization and minimal wastewater discharge, with a significantly reduced footprint and investment compared to traditional chemical production lines [6]. Group 3: Industrial Impact - The team's research has led to the industrialization of over 100 technological achievements, empowering nearly 300 enterprises and generating over 150 billion yuan in economic value in the past three years [7]. - The successful industrial-scale production of pharmaceutical-grade squalene and nearly 100% raw material utilization in a million-ton citric acid production line exemplifies the team's contributions to the biomanufacturing sector [7]. - The research outcomes are being integrated into educational materials, emphasizing the importance of aligning scientific research with industrial needs [6][7].