【科技日报】我科学家开发出T细胞改造新方法

Group 1 - The research team from the Chinese Academy of Sciences has developed a method called "histidine scanning" to enhance the sensitivity of T-cell receptors (TCRs) in identifying and eliminating cancer cells [1][2] - The study reveals that histidine can accurately locate the "key button" sites on TCRs responsible for recognizing cancer cells, thereby strengthening the interaction between TCRs and pMHC antigen molecules [1] - Enhanced TCRs significantly improve T-cell activation and their ability to capture cancer cells, preventing cancer cells from escaping detection [1][2] Group 2 - The method does not rely on the three-dimensional structural information of TCRs, allowing for simultaneous modification of multiple "key buttons" to boost TCRs' ability to target cancer cells [2] - Modified T-cells exhibit higher activation levels and killing power, while accurately distinguishing between cancerous and healthy cells [2] - The research shows significant efficacy in animal models, providing a new approach for developing next-generation cancer immunotherapies [2]