电子植入系统可监测胰岛细胞发育过程

Core Insights - Researchers from the University of Pennsylvania and Harvard have developed an electronic implant system that can monitor and influence the maturation of human islet cells, providing a key technological platform for creating functional human pancreas and new approaches for cell-based diabetes therapies [1][2]. Group 1: Technology Development - The team embedded a thin conductive mesh structure within lab-grown pancreatic tissue, allowing the electronic device to closely interact with biological tissue. This system can record electrical signals produced by islet cells and apply precise electrical stimulation to influence their development [1][2]. - The implantable device is described as "bionic" or "cyber-organ," combining electronic systems with living tissue to create a controllable biological system [1]. Group 2: Research Findings - The researchers implanted a stretchable electronic mesh within developing three-dimensional pancreatic organoids, which is thinner than a human hair. This structure was placed between cell layers, allowing cells to aggregate and form islets. The device enabled the recording of electrical activity from individual islet cells for up to two months, observing their maturation process [2]. - By introducing a 24-hour electrical activity cycle similar to the human circadian rhythm, the cells were able to maintain this rhythmic activity autonomously after several days of stimulation, leading to improved hormone secretion at appropriate times [2]. Group 3: Future Applications - The technology may have two potential applications: first, to "train" lab-cultured islet cells through electrical stimulation before transplanting them into patients; second, to retain the electronic mesh structure post-transplant for continuous monitoring and moderate stimulation of cells to prevent functional decline under stress or disease [2].