Merck (MRK) Begins Phase III NSCLC Study on KRAS Candidate

Merck (MRK) has initiated phase III study on its oral KRAS G12C inhibitor candidate, MK-1084, for first-line treatment of certain patients with metastatic non-small cell lung cancer (NSCLC).The study will evaluate MK-1084 in combination with Merck’s blockbuster PD-L1 inhibitor Keytruda in patients with metastatic NSCLC whose tumors harbor KRAS G12C mutations and express PD-L1 (tumor proportion score [TPS] ≥50%). In some early studies, MK-1084, in combination with Keytruda, has demonstrated some promising an ...