Article in Nature Scientific Reports Describes Mechanism of Action of SeaStar Medical's Selective Cytopheretic Device in the Immunomodulation of Excessive Inflammation

The SCD's immunomodulatory activity is due to its effects on circulating leukocytes, specifically neutrophils and monocytes, in a low ionized calcium blood circuit. To investigate its mechanism of action, the authors used in vitro blood circuits to interrogate several aspects of the therapy. They found that activated neutrophils adhering to the SCD fibers in its low calcium environment displayed characteristics of evolving cell senescence and were subsequently released and returned to circulating blood. "A ...