Eli Lilly reports promising data for alopecia and eczema drugs, eyes label expansion
Reuters· 2025-10-24 10:46
Core Insights - Eli Lilly announced safety and efficacy results from two late-stage studies for its approved drugs targeting alopecia and eczema [1] Group 1 - The studies are focused on evaluating the performance of existing medications in treating alopecia and eczema [1]
Booz Allen Hamilton Announces Second Quarter Fiscal Year 2026 Results
Businesswire· 2025-10-24 10:45
Core Insights - Booz Allen Hamilton announced preliminary results for the second quarter of fiscal year 2026 [6][9] - The company will host a conference call on October 24, 2025, to discuss these financial results [2][7] - Booz Allen Hamilton employs approximately 32,500 people globally and reported revenue of $12.0 billion for the 12 months ending March 31, 2025 [5] Financial Results - Preliminary results for the second quarter fiscal year 2026 were announced, with further details to be discussed in the upcoming conference call [6][9] Company Overview - Booz Allen Hamilton is an advanced technology company focused on defense, civil, and national security priorities, utilizing AI and cyber technologies [4] - The company aims to empower people to change the world through its technology solutions [4] Recent Developments - Booz Allen Hamilton expanded its partnership with SEEQC to accelerate quantum engineering solutions, enhancing capabilities for government and commercial clients [6] - The company secured a $1.58 billion contract for intelligence analysis related to countering weapons of mass destruction [8]
Australia's Westpac unit fined $13 million for home loans misconduct
Reuters· 2025-10-24 10:45
Core Viewpoint - Australia's Federal Court has imposed a penalty of A$20 million (approximately $13 million) on a Westpac unit due to extensive financial misconduct related to home loan arrangements, including the use of falsified payslips [1] Group 1: Financial Misconduct - The penalty reflects widespread financial misconduct in the arrangement of home loans by the Westpac unit [1] - Specific misconduct included the use of falsified payslips, which indicates serious ethical and compliance failures within the company [1] Group 2: Regulatory Response - The Federal Court's decision highlights the increasing scrutiny and regulatory actions being taken against financial institutions in Australia [1] - This case may set a precedent for future regulatory actions against similar misconduct in the financial services industry [1]
Lilly's baricitinib delivered near-complete scalp hair regrowth at one year for adolescents with severe alopecia areata in Phase 3 BRAVE-AA-PEDS trial
Prnewswire· 2025-10-24 10:45
Core Insights - The BRAVE-AA-PEDS trial is the first and largest study focused on children and adolescents with severe alopecia areata, showing that 71% of adolescents treated with baricitinib 4 mg achieved successful scalp hair regrowth at one year [1][2][4] - Eli Lilly plans to submit the trial data to global regulators for a potential label update for baricitinib, commercially known as Olumiant [1][9][10] Group 1: Trial Results - At one year, 54.1% of patients receiving baricitinib 4 mg and 31% receiving baricitinib 2 mg achieved successful hair regrowth, defined as 80% or more scalp hair coverage [7] - Among patients with severe disease, 71% receiving baricitinib 4 mg and 58.6% receiving baricitinib 2 mg achieved successful hair regrowth [7] - In a post-hoc analysis, 80% of adolescents diagnosed with severe AA less than two years before treatment achieved successful hair regrowth with baricitinib 4 mg [4] Group 2: Safety Profile - The safety profile of baricitinib in adolescents was consistent with that seen in adult trials, with no new safety signals observed after one year [5][8] - Common treatment-emergent adverse events included acne, upper respiratory tract infection, and influenza, with no deaths or major adverse cardiovascular events reported [5][8] Group 3: Future Plans and Context - Lilly intends to enroll a new cohort of children ages 6 to under 12 in the BRAVE-AA-PEDS trial in the next year [9][12] - Baricitinib is the most-researched JAK inhibitor in alopecia areata, with over 1,300 adults and 423 adolescents enrolled in clinical trials [10]
Gorman-Rupp Announces Increase in Quarterly Cash Dividend
Businesswire· 2025-10-24 10:45
Core Points - The Gorman-Rupp Company has declared a quarterly cash dividend of $0.19 per share, representing a 2.7% increase from the previous quarter's dividend of $0.185 per share [1][2] - This marks the 303rd consecutive quarterly dividend and the 53rd consecutive year of increased dividends, placing Gorman-Rupp among the top 50 U.S. public companies for dividend payments [2] Company Overview - Founded in 1933, The Gorman-Rupp Company is a leading designer, manufacturer, and international marketer of pumps and pump systems for various applications including water, wastewater, construction, and industrial uses [3]
Lilly's EBGLYSS (lebrikizumab-lbkz) delivered durable disease control when administered once every eight weeks in patients with moderate-to-severe atopic dermatitis
Prnewswire· 2025-10-24 10:45
Core Insights - Eli Lilly's EBGLYSS (lebrikizumab-lbkz) shows promising results in treating moderate-to-severe atopic dermatitis, with approximately 80% of patients achieving or maintaining meaningful skin improvement with less frequent dosing [1][5] - The company has submitted new data to the FDA for a potential label update, which could allow for a maintenance dosing schedule of once every eight weeks [1][3] Group 1: Clinical Data and Efficacy - In the Phase 3 ADjoin extension trial, patients receiving EBGLYSS every eight weeks achieved similar disease control rates as those receiving it every four weeks, with 79% and 86% achieving EASI 75, respectively [5][9] - The study also reported that 62% of patients on the eight-week regimen and 73% on the four-week regimen achieved IGA 0 or 1, indicating significant skin clearance [5][9] - There were no new safety findings or increased risk of immunogenicity associated with the less frequent dosing [5][9] Group 2: Treatment Flexibility and Patient Experience - The new dosing schedule could reduce the treatment burden for patients, allowing for as few as six maintenance doses per year, which may enhance patient adherence and quality of life [2][3] - The interleukin-13 (IL-13) inhibitor mechanism of EBGLYSS targets a key cytokine involved in atopic dermatitis, potentially offering a more effective treatment option for patients [2][20] Group 3: Regulatory and Market Position - Lilly is pursuing an FDA label update for the every-eight-week dosing option, while also exploring a twelve-week dosing regimen in ongoing studies [4][3] - EBGLYSS is positioned as a first-line biologic treatment for moderate-to-severe atopic dermatitis, with strong recommendations from the American Academy of Dermatology [4][8] Group 4: Commercial Strategy and Access - Lilly has secured coverage for EBGLYSS with all three major national pharmacy benefit managers, ensuring access for over 90% of individuals with commercial insurance [25] - The company is also working to expand Medicaid and Medicare coverage as part of its health access initiative [25]
Here's My Main Takeaway After the Cryptocurrency Flash Crash
Yahoo Finance· 2025-10-24 10:45
Key Points The crypto flash crash was caused by leverage and thin liquidity. Perpetual futures make up almost 70% of crypto trading volumes. Leverage can magnify price movements and add to volatility. 10 stocks we like better than Bitcoin › Cryptocurrency prices have started to recover after the Oct. 10 flash crash that erased billions in just 24 hours. Optimism following Bitcoin's (CRYPTO: BTC) all-time high quickly evaporated in the wake of new tariff fears. Crypto's total market cap fell about ...
US government shutdown will inflict temporary pain to economy
Reuters· 2025-10-24 10:41
A prolonged shutdown of the U.S. government amid a standoff over funding between Republicans and Democrats in Congress could dent economic growth in the fourth quarter, but much of the lost output would be recovered when normal operations resume. ...
Halper Sadeh LLC Encourages General Motors Company Shareholders to Contact the Firm to Discuss Their Rights
Businesswire· 2025-10-24 10:40
Core Viewpoint - Halper Sadeh LLC is investigating potential breaches of fiduciary duties by certain officers and directors of General Motors Company, encouraging shareholders to contact the firm to discuss their rights and possible legal actions [1][2]. Group 1: Shareholder Rights and Legal Options - Shareholders who acquired General Motors stock on or before February 24, 2021, may seek corporate governance reforms, return of funds, court-approved financial incentives, or other benefits [2]. - The firm operates on a contingent fee basis, meaning shareholders would not incur out-of-pocket legal fees or expenses [2]. Group 2: Importance of Shareholder Participation - Shareholder involvement is crucial for improving company policies, practices, and oversight, which can lead to enhanced transparency, accountability, and ultimately, increased shareholder value [3]. Group 3: Firm's Background and Experience - Halper Sadeh LLC represents global investors affected by securities fraud and corporate misconduct, having successfully implemented corporate reforms and recovered millions for defrauded investors [4].
GrafTech Reports Third Quarter 2025 Results
Businesswire· 2025-10-24 10:40
Core Insights - GrafTech International Ltd. reported strong sales volume growth and cost reductions in Q3 2025, achieving a 9% year-over-year increase in sales volume and a 10% reduction in cash cost of goods sold per metric ton [5][8][4] - The company generated positive adjusted EBITDA and free cash flow, reflecting progress towards normalized profitability levels [9][8] - GrafTech's liquidity position remains strong, with total liquidity of $384 million as of September 30, 2025, supporting its ability to navigate industry challenges [13][4] Financial Performance - Net sales for Q3 2025 were $144 million, a 10% increase from $131 million in Q3 2024, driven by higher sales volume and the recognition of $11 million in previously deferred revenue [6][5] - The net loss for Q3 2025 was $28 million, or $1.10 per share, an improvement from a net loss of $36 million, or $1.40 per share, in Q3 2024 [7][6] - Adjusted EBITDA for Q3 2025 was $13 million, compared to a negative $6 million in Q3 2024, aided by cost reductions and deferred revenue recognition [8][6] Operational Metrics - Sales volume for Q3 2025 was 28.8 thousand metric tons, a 9% increase year-over-year, with a significant 53% growth in the U.S. market [10][5] - Production volume was 26.6 thousand metric tons, resulting in a capacity utilization rate of 63% [11][10] - The weighted-average realized price for graphite electrodes was approximately $4,200 per metric ton, reflecting a 7% decrease compared to Q3 2024 [10][11] Outlook and Strategic Initiatives - The company expects an 8-10% year-over-year increase in sales volume for 2025, reflecting a disciplined approach to margin management [16][4] - GrafTech anticipates a 10% year-over-year decline in cash cost of goods sold per metric ton for 2025, exceeding previous guidance [18][4] - Long-term demand for graphite electrodes is expected to grow due to the steel industry's transition to electric arc furnace technology and decarbonization trends [20][4]