New data showcase the versatility and anti-tumor activity of the CAPTN-3 platform and its unique multi-arm design in treatment-resistant cancers     REHOVOT, Israel, Dec. 04, 2025 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. (“Purple Biotech” or “the Company”) (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance, today announced that it will present new preclinical data from its CAPTN-3 platform of conditionally activated ...

På baggrund af de skattepligtige indtægter for 2025 har Kapitalforeningen BLS Invest nu estimeret følgende ureviderede udlodninger for foreningens afdelinger for 2025 AfdelingISIN Valuta Udbytte pr. andelGlobale Aktier KLDK0060189041DKK138 Det bemærkes, at der alene er tale om estimerede udlodninger, hvorfor der vil kunne ske ændringer. Der gøres endvidere opmærksom på at f.eks. handelsaktivitet m.v. i den resterende del af året kan påvirke de estimerede udlodninger i såvel opadgående som nedadgående retni ...

Core Points - The 2025 Yangtze Culture Forum opened in Nanjing with over 300 participants from more than 30 countries, focusing on the cultural, ecological, and developmental significance of major rivers [1][2] - The theme "Flowing Rivers, Converging Future" emphasizes international cooperation on river culture and sustainable governance [2] - Jiangsu's geography and economy are significantly shaped by the Yangtze River, which serves as a lifeline for the region [3] - Xinhua News Agency aims to enhance global cultural exchange through the Yangtze River, promoting its cultural heritage and modern strategies [4] - UNESCO reaffirmed its commitment to sustainable river governance and cooperation among river cities facing global challenges [5] Group 1 - The forum gathered over 300 guests to discuss river-civilization heritage and modern cooperation strategies [2] - Jiangsu will leverage the Yangtze River's cultural heritage to enhance international dialogue and cooperation [3] - Xinhua plans to use the forum to advance research on Yangtze culture and promote it globally [4] Group 2 - UNESCO and Nanjing will continue to collaborate on promoting ethical stewardship and community engagement across river basins [5] - The forum aims to strengthen cultural and scientific cooperation among countries along major rivers [5]

Core Points - The Company declared a second dividend of 2.82 pence per share for the year ending 31 March 2026, payable on 27 February 2026 to shareholders on the register on 6 February 2026 [1] Financial Summary - The Company reported a loss of 0.64 pence per share, which is a 0.6% decrease on the opening net asset value, compared to a return of 8.51 pence per share for the same period in 2024 [4] - The net asset value as of 30 September 2025 is 112.72 pence per share, down from 116.22 pence per share as of 31 March 2025 [4] - The fund size increased to £268.3 million as of 30 September 2025, compared to £145.7 million as of 30 September 2024 [4] - A dividend of 2.91 pence per share was paid during the period, compared to 3.14 pence per share in the same period of 2024 [4]

Core Viewpoint - DEMIRE Deutsche Mittelstand Real Estate AG has adjusted its financial guidance for the 2025 fiscal year due to a larger property portfolio and lower operational costs, leading to increased rental income and funds from operations [2][3] Financial Performance - The company anticipates fewer property sales in 2025 than initially planned, as some transactions have been postponed to the following year, resulting in a larger portfolio [2][3] - The revised forecast expects rental income to reach the upper end of the previous estimate, now projected between EUR 52.0 million and EUR 54.0 million [3] - Funds from operations I (FFO I after taxes, before minority interests and interest on shareholder loans) are now expected to be between EUR 9.0 million and EUR 11.0 million, an increase from the previous forecast of EUR 5.0 million to EUR 7.0 million [3]

Core Insights - Crescent Biopharma has announced a strategic partnership with Kelun-Biotech to enhance its oncology pipeline, focusing on CR-001, a PD-1 x VEGF bispecific antibody, and several antibody-drug conjugates (ADCs) [1][3][4] - The company plans to initiate clinical trials for CR-001, CR-002, and CR-003 (SKB105) in 2026, with significant data readouts expected by the end of 2027 [1][2][10] - A private placement of $185 million is set to support clinical developments and provide a cash runway into 2028 [1][16][19] Partnership Details - The partnership grants Kelun-Biotech exclusive rights to develop and commercialize CR-001 in Greater China, while Crescent retains rights for SKB105 in the U.S., Europe, and other markets [4] - Both companies can independently develop CR-001 in additional combinations, including with proprietary ADC assets [4] Pipeline Updates - CR-001 is designed to target solid tumors by blocking PD-1 and VEGF, with a Phase 1/2 trial expected to start in Q1 2026 [11][12] - CR-002 targets PD-L1 and is on track for an IND submission in mid-2026, with proof-of-concept data anticipated in late 2027 [11][19] - CR-003 (SKB105) targets integrin beta-6 and is expected to enter clinical trials in Greater China in Q1 2026, with initial data expected in Q1 2027 [11][19] Financial Overview - The private placement involves the sale of approximately 13.8 million ordinary shares at $13.41 per share, expected to close around December 8, 2025 [17][19] - The net proceeds will be used for advancing clinical development and general corporate purposes, ensuring operations are funded into 2028 [19][20] Anticipated Milestones - Key milestones include the initiation of Phase 1/2 trials for CR-001 and CR-003 in 2026, with initial combination data from CR-001 and CR-003 expected by the end of 2027 [10][14][15]

Core Insights - Kraken Robotics Inc. has announced the appointment of Kim Butler to its Board of Directors and the hiring of Bernard Mills as Executive Vice President, Defence, indicating a strategic enhancement of its leadership team [1][6]. Leadership Appointments - Kim Butler has over 35 years of executive experience in financial, operational, and governance roles across various sectors, including technology and defence. She has held significant positions such as Chair of Audit and Special Committees and has expertise in corporate governance, strategic planning, and mergers and acquisitions [2][5]. - Bernard Mills will assume the role of Executive Vice President, Defence, effective January 12, 2026. He has extensive experience in the defence and aerospace sectors, having served as CEO and Managing Director at Stelia North America and President of Ultra Sonar Systems [6][7]. Strategic Importance - Kim Butler expressed her enthusiasm for joining Kraken Robotics, emphasizing her commitment to contributing to the company's growth in advanced 3D underwater imaging and subsea battery technologies [4]. - Bernard Mills highlighted the increasing global demand for underwater robotics and maritime systems, indicating that Kraken is well-positioned for significant expansion due to its strong portfolio and relationships with key customers [9]. Company Overview - Kraken Robotics is focused on transforming subsea intelligence through innovative technologies, including 3D imaging sensors and robotic systems, aimed at addressing challenges in ocean safety and infrastructure [12][13]. - The company operates globally, with a presence in North America, South America, and Europe, supporting clients in over 30 countries [15].

Companies to advance CR-001, a PD-1 x VEGF bispecific antibody, and SKB105, an integrin beta-6-directed antibody-drug conjugate (ADC), in global markets and China Collaboration designed to accelerate and expand the development of synergistic combinations with CR-001 and ADCs, including SKB105 CR-001 and SKB105 on track to enter Phase 1/2 monotherapy clinical trials in Q1 2026 with combination studies to follow CHENGDU, China and WALTHAM, Mass., Dec. 04, 2025 (GLOBE NEWSWIRE) -- Sichuan Kelun-Biotech Biophar ...

Core Insights - First Atlantic Nickel Corp. has successfully confirmed magnetically recoverable awaruite nickel alloy in all ten discovery holes at the RPM Zone, maintaining a 100% success rate in drilling [1][4][9] - The company is expanding its drilling program with four additional holes to explore the eastern, northern, and southern extensions of the RPM Zone, aiming to increase the drill-confirmed strike length to approximately 1.4 kilometers and width to 850 meters [2][9][10] Summary by Sections Discovery Success - All ten discovery holes at the RPM Zone intersected large-grain visible awaruite and returned positive magnetically recoverable nickel results, covering an area of approximately 800 meters in strike length by 750 meters in width [4][9] - Every hole has ended in mineralization, confirming that the system remains open in all directions [4] Expansion Drilling - Four additional drill holes (AN-25-11 to AN-25-14) have been added to the Phase 2X drilling program to test expansion potential in multiple directions [2][4] - The eastern expansion will focus on areas that have consistently returned the best magnetically recoverable nickel grades, particularly near Chrome Pond [3][9] - Hole AN-25-13 will test a 400-meter northern extension, while Hole AN-25-14 will explore a 200-meter southern step-out [2][10] Metallurgical and Processing Advantages - Awaruite, containing approximately 77% nickel, can be concentrated through magnetic separation and flotation, positioning the Pipestone XL Project as a potential secure input to a North American nickel supply chain [3][15] - The project supports a mine-direct-to-battery-refinery pathway, bypassing energy-intensive processes like smelting, which enhances environmental sustainability [3][16] - Magnetic separation achieves a 90% mass reduction, allowing for the recovery of nickel, chromium, and cobalt while minimizing waste [9][10] Future Prospects - The ongoing metallurgical program aims to create a marketable direct-to-refinery awaruite concentrate containing nickel and cobalt, with potential for high-grade chromium recovery as a byproduct [17] - Updates on recovery, separation, and preliminary concentrate products for nickel, chromium, and cobalt are anticipated in early 2026 [17]

Core Insights - McEwen Inc. has announced new drill results from its Froome Mine, indicating significant geological potential and active drilling to expand results [1][2] Group 1: Drill Results and Mineralization - The recent drill results have extended high-grade gold mineralization by 100 meters vertically, marking a 45% increase since July 2025 [2] - Gold mineralization has been extended up to 50 meters west, which may increase the number of defined ounces per vertical meter, thereby lowering future production costs [5] - Some of the deepest intersections confirm that gold mineralization remains open at depth, suggesting additional resources exist below the current planned limit of the mine [4] Group 2: Economic Implications - The potential to extend Froome's mine life and improve economics is highlighted, with mining expected to commence in H1 2026 in areas near recently completed underground infrastructure [6][9] - Greater mining flexibility is anticipated, enabling higher production and lower costs, with mill feed from multiple sources expected from H2 2026 [9] Group 3: Future Plans - Surface diamond drilling will continue into Q1 2026 to further define the mineralization that remains open to the west and at depth [17] - An updated resource estimate for Froome West is planned for publication at the end of February 2026 [17]