Core Insights - Polyrizon Ltd. has announced new preclinical data indicating that its proprietary naloxone hydrogel demonstrates superior mucoadhesion compared to an existing intranasal naloxone spray product, which may enhance opioid overdose reversal in real-world emergencies [1][5]. Group 1: Product Performance - The study utilized an ex-vivo rabbit nasal mucosa model to compare the persistence of Polyrizon's hydrogel formulation against a commercial product, revealing that Polyrizon's hydrogel maintained significantly higher levels of a fluorescence marker, indicating stronger and more durable mucosal retention (p < 0.0001) [2]. - Polyrizon's Trap and Target ™ (T&T) hydrogel exhibited significantly higher mucoadhesion levels, suggesting prolonged contact at the nasal deposition site and potentially improved bioavailability [3]. Group 2: Importance of Mucoadhesion - Enhanced mucoadhesion is critical for intranasal drug delivery, especially for emergency treatments like opioid overdose reversal, as it supports more reliable absorption and potentially faster onset of action [4]. Group 3: Company Perspective - The CEO of Polyrizon emphasized that the results validate the potential of the T&T hydrogel platform and highlight its advantages in intranasal drug delivery, marking an important milestone in advancing the Naloxone program [5]. - The new dataset builds on previously reported stability results, reinforcing the robustness of Polyrizon's formulation under various storage conditions, which collectively supports the potential for a safer and more effective intranasal naloxone product [5]. Group 4: Company Overview - Polyrizon is a development-stage biotech company focused on innovative medical device hydrogels delivered as nasal sprays, which create a barrier against viruses and allergens while also enhancing drug delivery through improved bioadhesion and retention [6].

Core Points - The maturity of Riksbank certificates will be prolonged, with the new settlement day set for December 17, 2025, and maturity on January 7, 2026 [1] - The first certificate auction in 2026 is scheduled for January 5, 2026, due to a non-banking day on January 6, 2026 [1] Summary by Category Maturity Changes - Riksbank certificates announced on December 16, 2025, will have their maturity extended [1] Auction Schedule - The first auction for the certificates in 2026 will occur on January 5, 2026 [1]

Core Viewpoint - Clairvest Group Inc. has signed an agreement to sell its minority interest in Acera Insurance Services Ltd. as part of Acera's merger with Navacord Corp, which is expected to close in the first quarter of 2026, pending regulatory and shareholder approvals [1][3]. Company Overview - Acera Insurance Services Ltd. was formed through the merger of Rogers Insurance and CapriCMW in September 2022 and is now one of Canada's largest independent brokerages with over 750 employee shareholders [2]. - The company provides property & casualty and group benefits insurance solutions to both commercial and personal clients [2]. Financial Performance - During Clairvest's three-year partnership, Acera achieved a 70% growth in EBITDA and completed 24 tuck-in acquisitions [2]. - The sale is projected to positively impact Clairvest's book value by approximately CAD$4.00 per share upon closing [3]. Management and Partnership - The leadership team at Acera, including CEO Lee Rogers and Chairman/President Andrew Kemp, will roll a significant amount of their equity into the merged entity with Navacord [1]. - Clairvest has been a crucial partner in Acera's growth, providing support and strategic insight that has strengthened the business [5][6]. Investment Strategy - Clairvest's investment model focuses on entrepreneur-centric minority ownership, allowing management partners to retain control while achieving transformative outcomes [6]. - Clairvest has a history of successful investments in the insurance sector, building on its track record with other companies [4][7].

Core Viewpoint - Daktronics, Inc. has appointed Ramesh Jayaraman as the new President and CEO, effective February 1, 2026, marking a significant leadership change aimed at driving the company's transformation and growth [1][2][5]. Leadership Transition - Ramesh Jayaraman will also join the Board of Directors upon approval, while Reece Kurtenbach will step down from the Board [2]. - Brad Wiemann will continue as Interim President and CEO until the end of the third fiscal quarter on January 31, 2026 [2]. Ramesh Jayaraman's Background - Jayaraman brings over 25 years of global operations experience, with a proven track record in driving transformational change and organic growth [3]. - His previous role was Senior Vice President and Americas Integration Leader for Bosch Home Comfort, where he led large-scale businesses and global teams [3][4]. - He has held senior leadership positions across various companies, including Harman Professional Solutions and Ariston Thermo Group, and has experience in consulting and business analysis [4]. Strategic Vision - Daktronics aims to leverage Jayaraman's extensive experience in international markets and system integration to accelerate growth and transformation [5]. - The company is focused on executing its business and digital transformation strategies to drive profitable growth and reduce costs, including implementing a tiered product strategy and enhancing sales and support capabilities [5]. Company Overview - Daktronics is a leading designer and manufacturer of dynamic video communication displays and control systems, recognized as the world's largest supplier of large-screen video displays and related technologies [6]. - The company operates in various sectors, including Live Events, Commercial, High School Park and Recreation, and Transportation, with a strong emphasis on product innovation and customer service [6].

Core Insights - Longeveron Inc. is participating in the Global CardioVascular Clinical Trialists Forum, highlighting its focus on cellular therapies for serious medical conditions [2][3] Company Overview - Longeveron Inc. is a clinical stage biotechnology company developing regenerative medicines to address unmet medical needs [4] - The company's lead investigational product is laromestrocel (Lomecel-B®), an allogeneic mesenchymal stem cell therapy derived from the bone marrow of young, healthy adult donors [4] - Laromestrocel has multiple potential mechanisms of action, including pro-vascular, pro-regenerative, anti-inflammatory, and tissue repair effects, with applications across various disease areas [4] - The company is pursuing three pipeline indications: hypoplastic left heart syndrome (HLHS), Alzheimer's disease, and Pediatric Dilated Cardiomyopathy (DCM) [4] - Laromestrocel has received five important FDA designations, including Orphan Drug, Fast Track, and Rare Pediatric Disease designations for the HLHS program, and Regenerative Medicine Advanced Therapy (RMAT) and Fast Track designations for the Alzheimer's program [4] Event Participation - Dr. Joshua Hare and Dr. Nataliya Agafonova will participate in multiple panel discussions at the CVCT Forum, focusing on cell therapy in heart failure trials and the importance of cell delivery routes [2][3] - Specific topics include mesenchymal stem cell therapy for dilated cardiomyopathy and strategies to streamline cell therapy innovation [3]

Netanya, Israel, Dec. 03, 2025 (GLOBE NEWSWIRE) -- Silynxcom Ltd. (NYSE American: SYNX) ("Silynxcom" or the "Company"), a manufacturer and developer of ruggedized tactical communication headset devices, today announced that it has received a purchase order exceeding $286,000 from the Israel Defense Forces (“IDF”) for the Company’s tactical communication headset systems. The IDF has long been a strategic customer of Silynxcom, and the Company believes that this new order illustrates the trust placed in the C ...

By a ruling that entered into force on 3 December 2025, the Panevėžys Regional Court decided to initiate bankruptcy proceedings for the private limited liability company Aliuminio fasadai, which is part of the PST Group AB group of companies. The court appointed Mindaugas Krupavičius as the insolvency administrator and instructed him to convene the first meeting of creditors within the time limit and according to the procedure established by law. Aliuminio fasadai UAB encountered difficulties rooted in the ...

New research by The Open University and PensionBee reveals how sexual orientation and plans for future children shape motivation to save for retirementNEW YORK, Dec. 03, 2025 (GLOBE NEWSWIRE) -- A landmark study by PensionBee, a leading retirement provider, and The Open University has uncovered a striking ‘legacy gap’ between gay and straight men – not in how much they save for retirement, but in why they save. Drawing on data from more than 28,000 UK retirement accounts and surveys of over 1,300 PensionBee ...

‘Aura’ named Word of the Year after generating 31.9B impressions and showcasing how social moments reshape culture and languageCHICAGO, Dec. 03, 2025 (GLOBE NEWSWIRE) -- Sprout Social (Nasdaq: SPT), an industry-leading provider of social media management and analytics software, today released its first-ever Social Media Dictionary, a comprehensive analysis of the words, phrases and viral movements that shaped global culture in 2025. Drawing on a year of cross-platform conversations, Sprout’s analysis shows ...

Core Insights - Las Vegas and Nashville have emerged as the highest-paying cities for freelancers in the U.S., with average earnings of $62,083 and $61,569 respectively, according to Fiverr's Freelance Economic Impact Report [4][5] - The report indicates a significant increase in the number of independent professionals across the top 30 U.S. markets, with a 4.3% annual growth rate, totaling approximately 6.9 million independent professionals [5][6] - Freelancing is reshaping the American workforce, allowing individuals to build flexible careers independent of traditional employment structures [6] Market Growth and Earnings - The fastest-growing markets for freelancers include Orlando and Miami (both at 32%), Nashville (24%), and Las Vegas (22%) [3] - Revenue growth was most pronounced in Miami (71%) and Orlando (62%), while New York, Los Angeles, and Miami had the highest overall number of freelancers [3] - The average earnings for independent professionals in the top 30 markets is $52,002, which is approximately $5,748 higher than the overall U.S. average [14] Economic Contribution - Independent professionals in the U.S. are estimated to generate $319 billion in revenue, contributing 1.1% to the U.S. GDP, with $208 billion generated in the top 30 markets [5] - Professional service freelancers (51% of independent workers) and technical service freelancers (26%) make significant contributions to both the workforce and revenue [14] Demographic Insights - The report categorizes cities into nine groups based on freelance economies, growth rates, and demographics, highlighting trends in younger and more diverse populations in certain markets [14] - There is a notable earnings gap, with a 60% difference between the highest average earnings market (Las Vegas) and the lowest (Minneapolis) [14]