Core Insights - Argenx SE presented new data on the efficacy and safety of VYVGART for generalized myasthenia gravis (gMG) at the 2025 AANEM and MGFA meetings, highlighting its potential to improve patient outcomes across various gMG populations [1][2][3] Efficacy and Safety Data - The pivotal Phase 3 ADAPT SERON trial demonstrated that AChR-Ab seronegative gMG patients treated with VYVGART achieved a statistically significant improvement in MG-ADL total score compared to placebo, with a mean change of 3.35 points at week 4 [6] - Approximately 60% of VYVGART-treated gMG patients achieved minimal symptom expression (MSE), with 88% sustaining MSE for at least 4 weeks [5][6] - Real-world data indicated that over 70% of patients treated with VYVGART significantly reduced glucocorticoid use while maintaining clinical benefits [5][15] Treatment Impact - VYVGART is positioned as a targeted, effective, and safe treatment for gMG patients, regardless of autoantibody status, with ongoing studies contributing to redefining treatment standards [4][7] - The ADAPT Jr study showed that VYVGART improved outcomes in adolescents with gMG, addressing a high unmet need in this population [8] Regulatory Plans - Argenx plans to share the ADAPT SERON trial results with the U.S. FDA to seek an expansion of the VYVGART label to include adult AChR-Ab seronegative gMG patients across all subtypes [7] Long-term Outcomes - Long-term treatment with VYVGART was associated with substantial reductions in oral glucocorticoid use, with 72.5% of patients achieving meaningful tapering and an average daily dose reduction of over 50% after 18 months [15][26]

ROBESONIA, Pa., Oct. 29, 2025 (GLOBE NEWSWIRE) -- Blaqclouds Inc. (OTC: BCDS), a leading Web3 infrastructure company, today announced the official launch of Deploy Launchpad, a full-suite, multi-chain token launch and ecosystem acceleration platform designed to empower developers, innovators, and organizations across the decentralized economy. Built to simplify the path from concept to capital, Deploy Launchpad integrates directly with Apollo Wallet and supports over 20 blockchains, including Ethereum (ETH) ...

Core Insights - AlphaTON Capital plans to invest significantly in GPU and data center resources to support the launch of Cocoon, a decentralized AI infrastructure announced by Telegram founder Pavel Durov [1][2][3] - Cocoon aims to provide secure and private AI inference through a distributed network, where developers will compensate GPU owners with TON cryptocurrency for processing requests [2][4] - The launch of Cocoon is seen as a pivotal moment in the integration of blockchain technology, data protection, and artificial intelligence [3][4] Company Strategy - AlphaTON Capital is committed to becoming a key contributor to the Cocoon ecosystem by deploying enterprise-grade GPU infrastructure to ensure sufficient computational capacity for major applications [3][4] - The company will utilize next-generation high-memory GPU models optimized for AI workloads across strategically located data centers, focusing on reliability and processing capacity [3][4] - AlphaTON Capital's participation highlights its strategic focus on the TON blockchain and Telegram-based AI applications, with the Cocoon network set to launch in November 2025 [4] Market Position - The Cocoon network is positioned to address a critical market need for privacy and security in AI, with AlphaTON Capital uniquely positioned as both a participant in the TON ecosystem and an infrastructure provider [4][6] - The company aims to provide institutional-grade exposure to the TON ecosystem and Telegram's extensive user base, leveraging its treasury strategy that includes direct token acquisition and strategic investments [6][7]

Core Insights - SKK Holdings Limited has appointed Chaince Securities LLC as its strategic advisor to develop a comprehensive tokenization and digital asset treasury strategy [1][2] - The collaboration aims to integrate digital asset capabilities into SKK's business model, enhancing capital efficiency and investor engagement [2][4] - SKK's CEO expressed confidence that this strategy will accelerate growth and add value for shareholders [3] Company Overview - SKK Holdings Limited is a civil engineering service provider based in Singapore, specializing in subsurface utility works [1][6] - The company has over 10 years of experience in various public utility projects, including power and telecommunication cable laying, water pipeline works, and sewer rehabilitation [6] Strategic Partnership - Chaince Securities will advise SKK on structuring its digital asset treasury, capital market strategy, and exploring staking and validator node opportunities [2][4] - This partnership reflects Chaince's expertise in bridging traditional finance with the digital asset economy [5][7]

Core Insights - Novartis presented new data on ianalumab for Sjögren's disease, highlighting its potential to significantly improve disease activity and reduce patient burden in Phase III trials [1][2][4] Clinical Trial Results - Ianalumab 300 mg monthly showed a clinically meaningful benefit in the NEPTUNUS-1 and NEPTUNUS-2 Phase III trials, with a greater reduction in disease activity compared to placebo, sustained through Week 52 [2][4] - Statistically significant improvement in the primary endpoint, ESSDAI, was observed at Week 48, with numerical improvements noted as early as Week 16 [4][5] - Secondary outcome measures also showed consistent numerical improvements, including physician- and patient-reported outcomes, although some did not reach statistical significance [5][7] Mechanism of Action - Ianalumab is a fully human monoclonal antibody that depletes B-cells and inhibits their activation and survival via BAFF-R blockade, addressing the B-cell dysfunction central to Sjögren's disease [3][9] Future Plans - Novartis plans to submit ianalumab for regulatory approval globally in early 2026, aiming to establish it as the first targeted treatment for Sjögren's disease [5][4] Disease Overview - Sjögren's disease is a systemic autoimmune condition affecting approximately 0.25% of the population, with a higher prevalence in women, leading to significant symptoms such as dryness, fatigue, and pain [10]

Profit. In the 9 months of this year, the group earned a net profit of €48.4 million Fee and commission income. Net fee and commission income grew by 8% over the year and exceeded €22.7 million Deposit portfolio. The deposit portfolio increased 11% since the beginning of this year and amounted to €3.75 billionLoan portfolio. The loan portfolio amounted to €3.7 billion, increasing by 8% over the year Share buyback. Artea Bank received permission from the ECB to buy back up to 4,500,000 of its own sharesPart ...

Kids Eat Free Every Day + Festive New Flavors Make This Season Extra Merry Denny’s Brings Holiday Cheer to the Booth with Rudolph the Red-Nosed Reindeer® Pancakes and Special Holiday Gifts NEW! Rudolph Everyday Value Slam® available only at Denny's Denny’s Brings Holiday Cheer to the Booth with Rudolph the Red-Nosed Reindeer® Pancakes and Special Holiday Gifts NEW! Color-changing Denny’s x Rudolph® collectible Bumble™ mug – available now at DinerDrip.com Spartanburg, SC, Oct. 29, 2025 (GLOBE NEWSWIR ...

MINNEAPOLIS, Oct. 29, 2025 (GLOBE NEWSWIRE) -- Clearfield, Inc. (NASDAQ: CLFD), a leader in community broadband fiber connectivity, today announced the election of Rebecca Seidel and Kathleen Skarvan to its Board of Directors, effective December 10, 2025. “We are pleased to welcome Rebecca and Kathleen to Clearfield’s Board of Directors,” said Ronald G. Roth, Clearfield’s Chairman of the Board. “Both Rebecca and Kathleen bring deep operational and strategic expertise that will enhance our board’s collective ...

Core Insights - Wix.com Ltd. has announced a strategic collaboration with PayPal Inc. to enhance AI-powered product discovery and commerce for Wix merchants [1][2] - The partnership will allow Wix merchants to sync their product data and inventory with PayPal's AI discovery and checkout services, facilitating a seamless integration without additional technical requirements [2][4] Group 1: Collaboration Details - The collaboration aims to position Wix merchants at the forefront of AI-driven shopping experiences, enabling them to reach new, high-intent channels [4][8] - Wix merchants will maintain brand ownership and customer relationships while utilizing PayPal's trusted protections during transactions [8] Group 2: Benefits for Merchants - Merchants will benefit from faster time to value through streamlined integration, making their product catalogs discoverable across supported AI channels [8] - The partnership is expected to enhance discovery and intent-driven purchasing journeys, moving beyond traditional search methods [8] - A single PayPal integration will allow Wix merchants to showcase products across multiple AI shopping experiences, including PayPal's shopping agent and Perplexity [8]

Aimed at incentivize large-scale vital data collection Medirom Medirom TOKYO, Oct. 29, 2025 (GLOBE NEWSWIRE) -- MEDIROM Healthcare Technologies Inc., (Headquarters: Minato-ku, Tokyo; President and CEO: Kouji Eguchi; listed on the Nasdaq Stock Market under the ticker symbol NASDAQ: MRM; hereinafter “the Company”) hereby announces the launch of a new treasury strategy utilizing cryptocurrency. As part of this strategy, the Board of Directors has resolved to hold Worldcoin (WLD), a Proof of Human authentica ...