Core Insights - Zorevunersen shows potential as a disease-modifying therapy for Dravet syndrome, supported by four years of clinical data and EEG assessments [1][2][3] Company Overview - Biogen Inc. is a leading biotechnology company focused on innovative science to develop new medicines [7] - Stoke Therapeutics specializes in RNA medicine aimed at restoring protein expression, with zorevunersen as its first investigational product [9] Product Information - Zorevunersen is an investigational antisense oligonucleotide targeting the underlying cause of Dravet syndrome by increasing NaV1.1 protein production [5] - The drug has received orphan drug designation and Breakthrough Therapy Designation from the FDA for Dravet syndrome [5] Clinical Studies - The ongoing EMPEROR Phase 3 study evaluates zorevunersen's efficacy in children with Dravet syndrome, focusing on seizure frequency and cognitive improvements [6] - Data from the Phase 1/2a and ongoing open-label extension studies will be presented at the 2025 American Epilepsy Society Annual Meeting [2][3] Disease Context - Dravet syndrome is characterized by severe seizures and cognitive impairments, with a significant portion of patients not achieving adequate seizure control with existing treatments [4] - Approximately 38,000 individuals are estimated to be living with Dravet syndrome in the U.S., UK, EU-4, and Japan [4]

VANCOUVER, British Columbia, Dec. 01, 2025 (GLOBE NEWSWIRE) -- Pulse Oil Corp. (“Pulse” or the "Company”) (TSXV: PUL) is pleased to announce that Pulse has entered into amending agreements to the two loan Facility Agreements (the “Facility Agreements”) with two arms-length parties to the Company (the “Lenders”) announced in the Company’s press release of June 5, 2025. Pursuant to the amending agreements, each of the Lenders has agreed to increase their respective loan to the Company (collectively, the “Loan ...

Cross-trial analysis supports plasma pTau as a potential early predictor of clinical benefit, reinforcing the biomarker-driven design of ProMIS’ PRECISE-AD trial ProMIS on track to leverage new plasma pTau insights with planned Q2 2026 interim readout Cambridge, Massachusetts, Dec. 01, 2025 (GLOBE NEWSWIRE) -- ProMIS Neurosciences Inc. (Nasdaq: PMN), a clinical-stage biotechnology company focused on the generation and development of antibody therapeutics and vaccines targeting toxic misfolded proteins in ne ...

Jerry Durso, accomplished industry leader, to succeed Vipin Garg, Ph.D. as Chief Executive Officer Transition follows seven years of strong leadership by Dr. Garg GAITHERSBURG, Md., Dec. 01, 2025 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a late clinical-stage biopharmaceutical company developing novel peptide-based therapeutics for liver and metabolic diseases, today announced a CEO succession plan under which Vipin Garg, Ph.D. will step down as the Company’s President and Chief Executive Officer e ...

HALIFAX, Nova Scotia, Dec. 01, 2025 (GLOBE NEWSWIRE) -- Morien Resources Corp. (“Morien” or the “Company”) (TSX-V: MOX) is pleased to announce that it has commenced a maiden drill program at the Lazy Head Aggregate Project (“Lazy Head” or the “Project”) in the Municipality District of Guysborough (the “MODG”), Nova Scotia (the “Drill Program” or “Program”). The Drill Program marks the next major milestone in advancing Lazy Head from a greenfield discovery into a technically defined, community-supported, exp ...

MONTREAL, Dec. 01, 2025 (GLOBE NEWSWIRE) -- The Bombardier team is proud to share that Moody’s has upgraded the company’s credit rating from B1 to Ba3, with a positive outlook. With this recent upgrade, Bombardier’s credit ratings are back in the Ba/BB category with both Moody’s and S&P for the first time in over a decade. This achievement reflects the company’s strong and consistent execution across business segments, solid financial performance and disciplined deleveraging efforts over recent years. With ...

NEW YORK, Dec. 01, 2025 (GLOBE NEWSWIRE) -- Nexxen International Ltd. (NASDAQ: NEXN) (“Nexxen” or the “Company”), a global, flexible advertising technology platform with deep expertise in data and advanced TV, today announced the Company repurchased 427,500 Ordinary Shares at an average price of $7.11 during November 2025. As of November 30, 2025, Nexxen had 56,669,327 Ordinary Shares outstanding (excluding treasury shares) and approximately $10.8 million remaining under its current share repurchase authori ...

Compared to the Previous Corresponding Quarterly Period, Revenue Increased 779% (US$133K to US$1.2M); Increase in Gross Profit; Strong Cash Position Growth Trajectory Remains Strong First Tranche of Previously Shareholder Approved Milestone Shares to be Issued After Reaching US$3M Revenue Milestone VANCOUVER, British Columbia, Dec. 01, 2025 (GLOBE NEWSWIRE) -- Beyond Oil Ltd. (TSX: BOIL) (“Beyond Oil” or the “Company”), a food-tech innovation company dedicated to reducing health risks associated with fried ...

Core Insights - Rick Seadler has been appointed as the Bowling Green Market President for Stock Yards Bank & Trust, bringing over 35 years of banking experience to the role [1][2] - Seadler's previous position was Regional President at Pinnacle Financial Partners, and he has held leadership roles in Louisville and Nashville [1][2] - Stock Yards Bank & Trust emphasizes community involvement and personalized customer service, aligning with Seadler's expertise [2] Company Overview - Stock Yards Bancorp, Inc. has $9.31 billion in assets and was incorporated in 1988, serving as the parent company of Stock Yards Bank & Trust Company, which was established in 1904 [4] - The company operates over 70 branches across Kentucky, Indiana, and Ohio, focusing on local leadership and community relationships [4]

A Vital Step in Advancing Permitting for Ore ExtractionTORONTO, Dec. 01, 2025 (GLOBE NEWSWIRE) -- McFarlane Lake Mining Limited (“McFarlane” or the “Company”) (CSE: MLM, OTC: MLMLF) a leading Canadian gold exploration company focused on advancing its flagship Juby Gold Project, located approximately 15 kilometers west from Gowganda, Ontario and approximately 90 kilometers west from Temiskaming Shores, Ontario is pleased to announce it has engaged Pinchin Ltd. (“Pinchin”), a leading environmental consulting ...