Core Insights - Abercrombie & Fitch Co. reported record third quarter net sales of $1.3 billion, reflecting a 7% increase compared to the previous year, marking the 12th consecutive quarter of growth [5][6][24] - The Hollister brand experienced significant growth of 16%, while Abercrombie brands saw a decline of 2% [5][7] - The company achieved an operating margin of 12.0%, with earnings per diluted share of $2.36, which exceeded expectations [5][6][24] Financial Performance - Net sales by segment for the third quarter were as follows: Americas at $1,057.4 million (up 7%), EMEA at $194.5 million (up 7%), and APAC at $38.7 million (down 6%) [4][7] - Operating income was reported at $155 million, down from $179 million in the previous year, resulting in an operating margin decrease from 14.8% to 12.0% [6][24] - Year-to-date share repurchases totaled $350 million, representing 9% of shares outstanding at the beginning of the year [5][9] Outlook - The company narrowed its full-year outlook to net sales growth of 6% to 7% and net income per diluted share in the range of $10.20 to $10.50 [5][17] - For the fourth quarter, the company anticipates net sales growth in the range of 4% to 6% and an operating margin around 14% [13][17] Cash Flow and Liquidity - As of November 1, 2025, the company had cash and equivalents of $606 million, down from $773 million at the beginning of the year [12][39] - The company reported net cash provided by operating activities of $313 million, while net cash used for investing activities was $95 million [12][41] Inventory and Capital Allocation - Inventories increased to $730 million compared to $575 million at the beginning of the year [12][39] - The company has $950 million remaining on its share repurchase authorization established in March 2025 [9][12]

Core Insights - Q-Gold Resources Ltd. has signed an agreement with Kappes, Cassiday & Associates to initiate a preliminary economic assessment (PEA) for the Quartz Mountain Gold Project in Oregon, USA [1][2] - The PEA will evaluate the project's economic potential, including mining methods, processing options, capital and operating costs, and projected financial returns [3] - The Quartz Mountain Gold Project has an estimated mineral resource of 1,543,000 ounces of gold at a grade of 0.96 g/t and 2,049,000 ounces of silver at a grade of 1.27 g/t [5] Company Developments - The engagement of KCA, along with a recently completed NI 43-101 technical report, positions Q-Gold to unlock significant shareholder value from the Quartz Mountain Gold Project [2] - The project was acquired from Alamos Gold in Q3 2025 and is located in a historically proven mining district [2][4] - The results of the PEA are expected in the coming months and will serve as a foundation for future technical studies and permitting activities [4] Strategic Positioning - The project benefits from its favorable location, established infrastructure, and solid mineral resource base, with gold being designated as a strategic asset in the USA [4] - Q-Gold is focused on advancing its portfolio of gold and silver assets toward production, with primary emphasis on the Quartz Mountain Gold Project and the Mine Centre Gold Project in Ontario, Canada [9]

Core Insights - BriaCell Therapeutics Corp. will present positive biomarker and survival data at the 2025 San Antonio Breast Cancer Symposium, highlighting advancements in cancer immunotherapy [1][6] - The company emphasizes its commitment to improving survival and clinical outcomes for cancer patients with unmet medical needs through its innovative therapies [2] Clinical Data and Presentations - The company will showcase three poster presentations at the symposium, focusing on positive Phase 2 safety and efficacy signals, as well as biomarker findings from both Phase 2 and pivotal Phase 3 studies [6] - The pivotal Phase 3 study of Bria-IMT+CPI is ongoing, with an interim analysis expected in the first half of 2026 [6] - The Bria-IMT regimen has received Fast Track Designation from the US FDA, indicating its potential significance in cancer treatment [6] Leadership Statements - William V. Williams, MD, President & CEO, expressed confidence in the pivotal Phase 3 study in metastatic breast cancer, supported by positive clinical data and biomarker findings [2] - Miguel A. Lopez-Lago, PhD, Chief Scientific Officer, highlighted the importance of biomarker data in understanding the mechanism of action of their novel immunotherapy [2] Company Overview - BriaCell is a clinical-stage biotechnology company focused on developing novel immunotherapies aimed at transforming cancer care [4]

Core Insights - LEQEMBI IQLIK, if approved, would be the first anti-amyloid treatment allowing at-home injections from the start of therapy for Alzheimer's disease [1][5] - The FDA has received a Supplemental Biologics License Application (sBLA) for LEQEMBI IQLIK, which is indicated for early Alzheimer's disease [1][5] - The sBLA is supported by data showing that subcutaneous administration of lecanemab is as effective as intravenous dosing [2][3] Group 1: Product Development and Approval - Eisai has completed the rolling submission of the sBLA for LEQEMBI IQLIK to the FDA, which has granted Fast Track Status [1] - The sBLA includes data from Phase 3 studies demonstrating that a 500 mg weekly subcutaneous dose provides equivalent exposure and benefits compared to bi-weekly intravenous administration [2] - If approved, the autoinjector would allow patients to choose between subcutaneous and intravenous administration throughout their treatment [3] Group 2: Mechanism of Action - LEQEMBI targets both protofibrils and amyloid plaques, which are key contributors to Alzheimer's disease progression [4] - Protofibrils are considered the most toxic form of amyloid-beta and are believed to cause significant neuronal damage [6] Group 3: Market Presence - LEQEMBI is currently approved in 51 countries and regions and is under regulatory review in 9 additional countries [5][29] - The U.S. FDA approved LEQEMBI IQLIK for weekly subcutaneous maintenance dosing in August 2025, following an 18-month intravenous treatment [5][30] Group 4: Safety Profile - The safety profile of LEQEMBI IQLIK is similar to that of the intravenous formulation, with a low incidence of systemic injection-related reactions [2][29] - Common adverse reactions include infusion-related reactions (26% with LEQEMBI vs. 7% with placebo) and amyloid-related imaging abnormalities (ARIA) [29]

Core Insights - Electra Battery Materials Corporation and Positive Materials Inc. have signed a Supply Chain Cooperation Agreement to enhance North America's lithium-ion battery and energy storage industries [1][2] - The partnership aims to establish a North American commercial and technical relationship for cobalt sulfate production, emphasizing ethical sourcing and strengthening the critical minerals supply chain [2][3] Company Overview - Electra is constructing North America's first battery-grade cobalt sulfate refinery, which is part of a strategy to localize critical minerals refining and reduce reliance on foreign supply chains [7] - The company is also involved in black mass recycling to recover critical materials from end-of-life batteries and is exploring growth opportunities in nickel refining and other battery materials [8] Project Details - Project Positive aims to build a sustainable pCAM manufacturing facility in Belledune, New Brunswick, utilizing proven technology [10] - The collaboration will focus on integrating Electra's cobalt sulfate with Positive's pCAM operations, aligning product specifications to meet customer needs [5][6] Strategic Goals - The agreement reflects a commitment to process ethically sourced battery raw materials domestically, enhancing the resilience and competitiveness of North America's critical minerals supply chain [2][4] - Electra's engagement with downstream clients and innovators ensures alignment across the value chain from mine to market, contributing to North America's broader battery materials strategy [6]

Core Insights - Clearmind Medicine Inc. has commenced patient enrollment for its Phase I/IIa clinical trial of CMND-100 for Alcohol Use Disorder (AUD) at Tel Aviv Sourasky Medical Center, marking a significant milestone in the global study [1][2][4] - The trial aims to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of CMND-100, a non-hallucinogenic, oral MEAI-based compound, with initial results indicating excellent safety and adherence [3][4] - Clearmind's intellectual property portfolio includes nineteen patent families with 31 granted patents, and the company plans to pursue additional patents to enhance its portfolio [5] Company Overview - Clearmind is a clinical-stage biotech company focused on developing novel neuroplastogen-derived therapeutics to address under-treated health issues, particularly AUD [1][4] - The company is committed to researching and commercializing psychedelic-based compounds as regulated medicines, foods, or supplements [4] Clinical Trial Details - The Phase I/IIa trial is being conducted at multiple prestigious sites, including Yale School of Medicine and Johns Hopkins University, in addition to TASMC [2] - The first completed cohort of the trial has shown no serious adverse events, indicating a positive safety profile for CMND-100 [3]

Core Insights - Unicycive Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing therapies for kidney disease [1][2] - The company will participate in two investor events in December 2025, including the Piper Sandler 37th Annual Healthcare Conference and a Noble Capital Markets Virtual Presentation [1] Company Overview - Unicycive's lead investigational treatment is oxylanthanum carbonate, a phosphate binding agent under FDA review for treating hyperphosphatemia in chronic kidney disease patients on dialysis [2] - The second investigational treatment, UNI-494, targets conditions related to acute kidney injury and has received orphan drug designation from the FDA for preventing Delayed Graft Function in kidney transplant patients [2] - UNI-494 has completed a Phase 1 dose-ranging safety study in healthy volunteers [2]

ANN ARBOR, Mich., Nov. 25, 2025 (GLOBE NEWSWIRE) -- Kraig Biocraft Laboratories, Inc. (OTCQB: KBLB) ("Company" or "Kraig Labs"), a world leader in spider silk technology*, announces the launch of a key hiring initiative at its production operations in Southeast Asia. This expansion of the Company's production workforce is driven by rapidly increasing throughput, an expanded operational footprint, and preparations for the opening of its newest production center, now in active development. The Company is ramp ...

Core Viewpoint - Clearfield, Inc. has increased its share repurchase program from $65 million to $85 million, reflecting the Board's belief that the current share price does not fully represent the company's long-term potential [2]. Share Repurchase Program - The Board of Directors has authorized an increase in the share buyback program, leaving approximately $28.4 million available for additional repurchases, in addition to the $8.4 million remaining as of September 30, 2025 [2]. - The repurchase program allows Clearfield to buy shares through various methods, including open-market transactions and block trades, in accordance with relevant securities regulations [2][3]. - The program does not obligate the company to repurchase a specific amount of stock during any period and will be funded by cash on hand [3]. Company Overview - Clearfield, Inc. designs, manufactures, and distributes fiber optic management, protection, and delivery products for communications networks, serving various markets including traditional and alternative carriers, utilities, enterprises, and military [4]. - The company is headquartered in Minneapolis, MN, and deploys over a million fiber ports each year [4].

NEW HAVEN, Conn., Nov. 25, 2025 (GLOBE NEWSWIRE) -- Invivyd, Inc. (Nasdaq: IVVD) today announced that management will participate in a fireside chat at the 8th Annual Evercore Healthcare Conference on Tuesday, December 2, 2025, at 2:35 p.m. ET in Miami, FL. A live webcast of the fireside chat will be available in the investor section of the company's website at investors.invivyd.com and will be archived for approximately 90 days following the presentation. About InvivydInvivyd, Inc. (Nasdaq: IVVD) is a biop ...