Core Insights - Actuate Therapeutics announced positive topline results from the Phase 2 trial of elraglusib in combination with gemcitabine/nab-paclitaxel for treating metastatic pancreatic ductal adenocarcinoma, indicating a significant improvement in overall survival [1][2][5] Study Results - The study achieved its primary endpoint with a median overall survival of 10.1 months for the elraglusib/GnP group compared to 7.2 months for the GnP group, resulting in a 37% reduction in the risk of death (HR = 0.63) [2][8] - The 12-month survival rate was 44.1% in the elraglusib/GnP arm versus 22.3% in the GnP arm, demonstrating a doubling of survival rates [2][8] - Continued survival benefits were observed at 18 and 24 months, with survival rates of 19.7% vs 4.4% and 13.8% vs 0% for elraglusib/GnP compared to GnP alone, respectively [8] - The overall response rate was numerically improved at 29.0% for the elraglusib/GnP arm compared to 21.8% for the GnP arm [8] Safety Profile - The trial met its primary safety endpoint, with treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) in the elraglusib/GnP arm being similar to those in the GnP arm, indicating a favorable risk-benefit profile [8] - Most treatment-related adverse events (TRAEs) were Grade 1-2, with transient visual impairments being the most common [8] Mechanism of Action - Elraglusib works by inhibiting GSK-3β, which may enhance chemotherapy activity, activate anti-tumor immunity, and regulate gene expression, potentially leading to improved survival outcomes [10][11] Clinical Context - The KOL event highlighted the unmet need in mPDAC and the potential of elraglusib to reshape treatment paradigms, emphasizing the importance of new drugs with unique mechanisms [4][5]

VANCOUVER, British Columbia, June 02, 2025 (GLOBE NEWSWIRE) -- Foremost Clean Energy Ltd. (NASDAQ: FMST) (CSE: FAT) (“Foremost” or the “Company”) is pleased to announce the appointment of Cameron MacKay as Vice President of Exploration effective June 01, 2025. Mr. MacKay is a seasoned uranium exploration executive with over a decade of experience and a track record of uranium discovery in the Athabasca Basin. “We are extremely pleased to welcome Cameron to Foremost's leadership team," said Jason Barnard, Pr ...

On 5 May 2025, Schouw & Co. initiated a share buy-back programme as outlined in Company Announcement no. 20 of 2 May 2025. Under the programme, Schouw & Co. will acquire shares for up to DKK 120 million during the period 5 May to 31 December 2025. The buy-back will be structured in accordance with Regulation (EU) No. 596/2014 of the European Parliament and of the Council of 16 April 2014 on market abuse (MAR) and the Commission’s delegated regulation (EU) 2016/1052 of 8 March 2016 (“Safe Harbour” rules). Tr ...

Los Angeles, June 02, 2025 (GLOBE NEWSWIRE) -- The Board of Triller Group Inc (Nasdaq: ILLR) (“Triller Group”, “the Group” or “the Company”) is pleased to announce the completion of its strategic review, resulting in the reorganization of the Group into three interconnected core business units: Social Media (Triller App)Fintech/Financial Service (AGBA Group) Combat Sports (BKFC) The Board of the Company extends its gratitude to Mr. Bobby Sarnevesht for his contributions since the acquisition of the predece ...

New AI-powered Features Deliver Actionable Insights and Enhanced CollaborationPALO ALTO, Calif., June 02, 2025 (GLOBE NEWSWIRE) -- Broadcom (NASDAQ: AVGO) today announced the general availability of the newest investment made to VMware Tanzu CloudHealth, a comprehensive new user experience that delivers a suite of feature enhancements and new AI-powered features like Intelligent Assist and Smart Summary. The new CloudHealth experience brings more accurate data and actionable insights to the entire FinOps Te ...

REDWOOD CITY, Calif., June 02, 2025 (GLOBE NEWSWIRE) -- Check Point® Software Technologies Ltd. (NASDAQ: CHKP), a pioneer and global leader of cyber security solutions, today announced that U.S. News & World Report has named the company among its 2025-2026 list of Best Companies to Work For. In addition, Check Point was also recognized as a Best Company to Work For in the IT industry. This recognition highlights Check Point’s commitment to fostering a culture of innovation, inclusion, and continuous growth ...

Growing Consumer Demand for Premium, Protein-Rich FoodsSPRINGDALE, Ark., June 02, 2025 (GLOBE NEWSWIRE) -- Tyson Foods, a world class food company and recognized leader in protein, has announced the launch of Wright Brand Premium Sausage Links. Known for its superior, hand-cut, real wood smoked bacon since 1922, Wright Brand, which is owned by Tyson Foods, continues its tradition of quality, offering consumers a bold and fresh taste with smoked sausage links. The new product line includes three distinct var ...

Core Insights - LPL Financial LLC has announced the launch of a new independent practice, Arv Private Wealth, by financial advisors Christian Reuter, James "Scott" Robinson, and Michael Capeder, who collectively manage approximately $330 million in advisory, brokerage, and retirement plan assets [1][2] Group 1: Company Overview - LPL Financial is one of the fastest-growing wealth management firms in the U.S., supporting over 29,000 financial advisors and approximately 1,200 financial institutions, with around $1.8 trillion in brokerage and advisory assets [6] - The firm offers a variety of advisor affiliation models, investment solutions, fintech tools, and practice management services, allowing advisors to choose the business model and resources they need [6] Group 2: Team Background - Reuter and Robinson have collaborated since 2012, bringing a combined six decades of financial industry experience, while Capeder joined the industry in 2018 [2] - The name "Arv" is derived from the Danish word for "legacy" and "heritage," reflecting the firm's commitment to providing a holistic client experience [2] Group 3: Business Model and Support - The team chose LPL's Strategic Wealth Services for its combination of entrepreneurial freedom and comprehensive business support, which includes operational and strategic assistance [3] - Advisors benefit from an integrated service model that includes simplified pricing, technology, and dedicated support, allowing them to focus on client needs [3][4] Group 4: Client Experience - The firm aims to be more than just financial advisors, positioning themselves as trusted confidants and guides for their clients [3] - LPL's tools, such as Admin Solutions and ClientWorks, are designed to enhance client interactions and streamline account management [4]

Group 1 - Alma íbúðafélag hf. is conducting a closed offering on June 5, 2025, for three-month and six-month unsecured bonds, with a nominal value of 20 million ISK each [1][2] - The offering will be managed by Arctica Finance hf. and will utilize a Dutch auction method, where all accepted bids will be offered to investors at the highest accepted flat rates [1] - The results of the offering will be publicly announced no later than the next business day after the offering [2] Group 2 - The offering is exempt from the requirement for a prospectus under EU Regulation No. 2017/1129 and Icelandic law No. 14/2020 [3] - This announcement is for informational purposes only and does not constitute an offer to purchase or subscribe for the company's securities [4] - Further details regarding the bond issuance can be found on the company's website [4]

Core Viewpoint - Fly-E Group, Inc. has announced a public offering of 28,595,553 shares of common stock and 57,191,106 warrants at a price of $0.2428 per share, aiming to raise approximately $6.94 million for inventory and production costs [1][2]. Group 1: Offering Details - The public offering includes common stock sold with two warrants per share, with each warrant exercisable at an exercise price of $0.2913 [1]. - The offering is expected to close on or about June 3, 2025, pending customary closing conditions [2]. - The gross proceeds from the offering are anticipated to be around $6.94 million before deducting fees and expenses [2]. Group 2: Company Overview - Fly-E Group, Inc. specializes in designing, installing, selling, and renting smart electric motorcycles, electric bikes, and electric scooters under the brand "Fly E-Bike" [6]. - The company's mission is to promote eco-friendly transportation and contribute to a more sustainable future [6]. Group 3: Regulatory Information - The securities are being offered under a registration statement on Form S-1, which was declared effective by the SEC on May 15, 2025 [4]. - A final prospectus will be filed with the SEC and will be available on their website [4].