NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR DISSEMINATION IN THE UNITED STATES TORONTO, Aug. 27, 2025 (GLOBE NEWSWIRE) -- Critical One Energy Inc. (formerly Madison Metals Inc.) (“Critical One” or the “Company”) (CSE: CRTL) (OTCQB: MMTLF) (FSE: 4EF0) is pleased to announce that, further to the press release issued on August 18, 2025, the Company has closed its oversubscribed, non-brokered financing and issued 5,001,999 units (the “Units”) at a price of CDN$0.60 per Unit for aggregate gross proceeds of ...

Company Announcement - C3is Inc. will release its second quarter financial results for the period ended June 30, 2025, before the market opens in New York on September 2, 2025 [1] - A conference call will be hosted by the company's management on September 2, 2025, at 10:00 am ET to present the results and discuss the company's operations and outlook [1] Webcast Information - There will be a live and archived webcast of the conference call available on the C3is Inc. website [2] - Participants are advised to register approximately 10 minutes prior to the start of the webcast, which will be in listen-only mode [2] Company Overview - C3is Inc. is a ship-owning company that provides seaborne transportation services to dry bulk and tanker charterers, including major national and private industrial users, commodity producers, and traders [3] - As of the end of Q2 2025, the company owned three Handysize dry bulk carriers and one Aframax oil tanker, with a total capacity of 213,464 deadweight tons (dwt) [3] - C3is Inc.'s shares are listed on the Nasdaq Capital Market under the symbol "CISS" [3]

Company Overview - Horizon Aircraft (NASDAQ: HOVR) is an advanced aerospace engineering company developing one of the world's first hybrid electric Vertical Take-Off and Landing (VTOL) aircraft, the Cavorite X7 eVTOL [5]. Upcoming Events - Horizon Aircraft management will participate in the Gabelli Aerospace & Defense Symposium on September 4, 2025, in New York City, including a fireside chat and 1x1 investor meetings [1]. - On the same day, management will also attend the Deutsche Bank Aviation Forum for 1x1 investor meetings [2]. - From September 8-10, 2025, management will participate in the H.C. Wainwright Global Investment Conference in New York City, focusing on 1x1 investor meetings [3]. - Horizon Aircraft will be present at the Rare Earth Mines, Magnets and Motors 2025 event on September 23-24 in Toronto, where management will participate in a panel discussion and showcase a large-scale prototype [4]. Product Development - The Cavorite X7 eVTOL is designed to fly most missions like a normal aircraft while offering industry-leading speed, range, and operational utility, with a focus on safety and performance [5].

Core Insights - The article highlights a landmark meeting co-sponsored by LIXTE Biotechnology Holdings, focusing on the activation of oncogenic signaling as a novel cancer treatment strategy [1][2] - LIXTE's lead compound, LB-100, was presented as a first-in-class PP2A inhibitor that activates oncogenic signaling, leading to cancer cell toxicity [2][4] Group 1: Conference Highlights - The conference introduced a paradigm shift in cancer therapy, advocating for the activation of oncogenic pathways rather than solely inhibiting them [3] - LB-100 exemplifies this approach by inhibiting PP2A, which removes a cellular "off switch," resulting in uncontrolled signaling that drives cancer cells to self-destruction [4] - Presentations at the conference reinforced the recognition of PP2A inhibition as a new therapeutic frontier, supporting LB-100's role as a platform therapy [5] Group 2: Company Positioning - By co-sponsoring the meeting, LIXTE positioned itself as a global thought leader in innovative cancer therapies, demonstrating its commitment to advancing cancer research [6] - LIXTE is focused on developing therapies targeting the PP2A pathway, with LB-100 showing strong preclinical results and early-stage clinical tolerability [7] - The company is currently advancing a proof-of-concept trial in Ovarian Clear Cell Carcinoma, indicating its active role in clinical development [7]

Core Viewpoint - Sompo Holdings is acquiring 100% of Aspen Insurance Holdings for $37.50 per share in cash, totaling approximately $3.5 billion, which enhances Sompo's portfolio and strengthens its position in specialty insurance and reinsurance markets [2][11]. Group 1: Transaction Overview - The merger agreement involves the redemption of all outstanding Class A ordinary shares of Aspen for cash and their delisting from NYSE, while preference shares will remain outstanding [1][12]. - The transaction is expected to close in the first half of 2026, pending regulatory approvals and customary closing conditions [13]. Group 2: Strategic Benefits - The acquisition diversifies Sompo's portfolio geographically, particularly in high-growth international markets, and enhances its underwriting expertise in core specialty insurance and reinsurance lines [1][5]. - Aspen's expertise in various global reinsurance lines and its top-tier Lloyd's syndicate will provide Sompo access to complex risks and untapped markets [6]. Group 3: Financial Impact - The transaction is anticipated to be immediately accretive to Sompo's return on equity (ROE) post-closing, contributing significantly to the group's financial profile [10]. - Aspen's recent financial performance includes a combined ratio of 87.9% and an operating return on average equity of 19.4% for the twelve months ended December 31, 2024 [10]. Group 4: Premium and Valuation - The acquisition price of $37.50 per share represents a 35.6% premium to Aspen's unaffected share price of $27.66 as of August 19, 2025 [11]. - This premium reflects the quality and potential of Aspen's business as recognized by Sompo [4]. Group 5: Leadership and Integration - Sompo Group CEO Mikio Okumura emphasized the transaction as part of their strategy to enhance resilience and promote collaboration within the group [3]. - James Shea, CEO of Sompo P&C, highlighted that strategic acquisitions are key to building a robust global platform, and Aspen represents a timely opportunity in the market cycle [4].

BRANFORD, Conn., Aug. 27, 2025 /PRNewswire/ -- Azitra, Inc. ("Azitra") (NYSE American: AZTR), a clinical stage biopharmaceutical company focused on developing innovative therapies for precision dermatology, today announced the dosing of the first patient in its Phase 1/2 clinical trial of ATR04-484, a topically applied live biotherapeutic product candidate designed to treat EGFR inhibitor ("EGFRi")-associated rash. Azitra has received Fast Track designation from the FDA for EGFRi associated rash, which impa ...

Core Insights - Cellectar Biosciences, Inc. announced the acceptance of an abstract for oral presentation at the AACR Special Conference on Pediatric Cancer, focusing on interim data from the CLOVER-2 Phase 1b study of iopofosine I 131 in pediatric high-grade glioma patients [1][2] Group 1: Presentation Details - The oral presentation titled "Precision Radiotherapy for Incurable Brain Tumors: Phase 1b Dose & Regimen Optimization Study of Iopofosine I 131 in Inoperable Relapsed or Refractory Pediatric High-Grade Glioma, Interim Data Assessment" is scheduled for September 26, 2025, at 2:50 pm Eastern time [3] - Jarrod Longcor, the chief operating officer of Cellectar, will present the findings during the plenary session [3] Group 2: Background on Pediatric High-Grade Gliomas - Pediatric high-grade gliomas are aggressive tumors affecting the brain and central nervous system, with poor median progression-free survival (PFS) of approximately 2.25 months and overall survival (OS) of about 5.6 months for relapsed cases [4] Group 3: CLOVER-2 Trial Overview - The ongoing Phase 1b trial of iopofosine I 131 includes children, adolescents, and young adults with relapsed or refractory pediatric high-grade gliomas across multiple sites in the U.S. and Canada [5] - The study evaluates the safety and tolerability of two dosing cohorts, with one cohort receiving 20 mCi/m² and the other 10 mCi/m², both separated by 14 days [5] - The trial aims to determine therapeutic activity defined by PFS and OS, as well as antitumor activity through tumor volume reduction [5] Group 4: Company Overview - Cellectar Biosciences is a late-stage clinical biopharmaceutical company focused on developing proprietary drugs for cancer treatment, utilizing its Phospholipid Drug Conjugate™ (PDC) delivery platform [6] - The company's product pipeline includes iopofosine I 131, CLR 121225, and CLR 121125, targeting various solid tumors with significant unmet needs [7][8] - Iopofosine I 131 has received multiple designations from the FDA, including six Orphan Drug and four Rare Pediatric Drug designations [9]

Core Insights - MannKind Corporation has announced that United Therapeutics Corporation has exercised its option to develop a second dry powder inhalation therapy under their 2018 collaboration agreement [1][2] Group 1: Collaboration and Agreement Details - The original agreement led to the FDA approval of Tyvaso DPI in May 2022 and included an option for United Therapeutics to expand the license to additional active ingredients [2] - Under the expanded agreement, MannKind will formulate a second investigational molecule using its proprietary Technosphere platform, while United Therapeutics will handle preclinical and clinical development [2] - MannKind will receive an upfront payment of $5 million, with potential development milestone payments of up to $35 million and 10% royalties on net sales of any resulting product [3] Group 2: Development Activities - Formulation and development activities for the new investigational molecule will commence immediately [4] Group 3: Company Overview - MannKind Corporation focuses on developing and commercializing innovative inhaled therapeutic products and devices to address serious unmet medical needs, particularly in endocrine and orphan lung diseases [5] - The company aims to utilize its formulation capabilities and device engineering to alleviate the burden of diseases such as diabetes, NTM lung disease, pulmonary fibrosis, and pulmonary hypertension [6]

Core Viewpoint - NRx Pharmaceuticals has announced an expanded access policy for NRX-100, a preservative-free ketamine, following its Fast Track designation by the FDA for treating suicidal ideation in patients with depression, including bipolar depression [1][6]. Group 1: Expanded Access Policy - NRX-100 is now available for expanded access to eligible patients, addressing an unmet need in treating suicidal depression [2][6]. - Physicians can request NRX-100 for patients who are not responsive to or cannot tolerate approved treatment options [3][7]. - The company emphasizes the urgent need for NRX-100 for patients with suicidal depression [3]. Group 2: FDA Designation and Clinical Development - The FDA granted Fast Track designation for NRX-100 based on preliminary data indicating its potential to meet an unmet medical need [2][6]. - NRX Pharmaceuticals is also developing NRX-101, which has received Breakthrough Therapy Designation for treating suicidal bipolar depression [5]. Group 3: Patient Statistics and Clinical Trials - Approximately 13 million adults in the U.S. seriously consider suicide each year, with a suicide occurring every 11 minutes [6]. - NRX has filed an Abbreviated New Drug Application (ANDA) and initiated a New Drug Application for NRX-100, based on results from well-controlled clinical trials [8].

Company Overview - Belite Bio, Inc is a clinical-stage drug development company focused on novel therapeutics for degenerative retinal diseases with significant unmet medical needs, including Stargardt disease type 1 and Geographic Atrophy in advanced dry age-related macular degeneration [2] - The lead candidate, Tinlarebant, is an oral therapy aimed at reducing toxin accumulation in the eye, currently undergoing Phase 3 and Phase 2/3 studies [2] Upcoming Events - The executive management team will participate in three investor conferences: - Cantor Global Healthcare Conference on September 5, 2025, at 8:00 am ET - Morgan Stanley 23rd Annual Global Healthcare Conference on September 8, 2025, at 5:35 pm ET - H.C. Wainwright 27th Annual Global Investment Conference on September 9, 2025, at 8:00 am ET [3] - Webcasts of the presentations will be available on the investor relations section of the Belite Bio website, with replays archived for 90 days [1]