Zhi Hui Ya·2025-03-06 02:53Investment Rating - The report does not explicitly state an investment rating for the small nucleic acid industry. Core Insights - The small nucleic acid field is experiencing significant advancements in patent strategies, particularly in the areas of chemical modifications and delivery technologies. Companies like Alnylam are leading the way in establishing a strong patent barrier through innovative approaches to RNA modifications and targeted delivery systems [4][24][25]. Summary by Sections Current Patent Landscape - The report outlines the current patent landscape in the small nucleic acid sector, highlighting key patents related to siRNA mechanisms and structural features. Early patents primarily cover siRNA mechanisms and typical structural characteristics, with companies like Alnylam acquiring exclusive licenses to build their patent barriers [8][9]. Challenges in Chemical Modification Searches - The report identifies challenges in searching for chemical modifications, including the diversity of modification descriptions and the lack of commercial databases supporting searches by chemical type. It emphasizes the need for standardized modification descriptions to facilitate better patent searches [22][27][32]. Breakthroughs in Domestic Small Nucleic Acid Design - The report discusses breakthroughs in domestic small nucleic acid design, focusing on the development of siRNA targeting validated genes. It emphasizes the importance of establishing "target patents" to protect against early entrants in the market [11][39]. Case Study: HSD17B13 - A case study on HSD17B13 highlights the active research and patenting efforts by companies like Regeneron and Alnylam in developing RNAi therapies targeting this gene. The report details the specific sequences and modifications involved in these patents [37][39][54]. Patent Search Workflow - The report outlines a comprehensive workflow for patent searches in the small nucleic acid field, including target name searches, sequence searches, and modification searches. This structured approach aims to streamline the identification of relevant patents and potential infringement risks [36][45][51].