Investment Rating - The report indicates a strong growth trajectory for the GLP-1RA market, with an expected market size of 71.7 billion yuan by 2029, reflecting a compound annual growth rate (CAGR) of 22.2% from 2023 [4][7]. Core Insights - GLP-1 receptor agonists (GLP-1RA) have become core therapeutic agents in the treatment of metabolic diseases due to their multifaceted pharmacological effects, including glycemic control, weight management, and cardiovascular protection [4]. - The market is characterized by intense competition, with multinational pharmaceutical companies holding a dominant position while domestic firms rapidly advance through local resources and policy support [4][8]. - The demand for GLP-1RA is driven by the rising prevalence of metabolic diseases, particularly diabetes and obesity, alongside increasing patient awareness and clinical application [8][10]. Market Background - GLP-1RA drugs are defined as medications that mimic the action of glucagon-like peptide-1 (GLP-1) to regulate blood sugar, manage weight, and protect organs, available in short-acting, long-acting, and oral formulations [5]. - The market has evolved significantly since the approval of the first GLP-1RA in 2005, with a notable increase in long-acting formulations that enhance patient compliance and expand indications beyond diabetes to include obesity [6]. Market Status - The GLP-1RA market in China is projected to grow from 10.74 billion yuan in 2023 to 71.7 billion yuan by 2029, driven by a CAGR of 22.2% [7]. - The market is currently experiencing rapid development, with domestic companies accelerating the development of generic drugs as patents for leading products expire [9]. - The demand for GLP-1RA remains high, with a diabetes prevalence rate of 11.9% in China and a treatment rate of only 33%, indicating significant unmet clinical needs [10]. Market Competition - The competitive landscape is divided into three tiers: - The first tier includes multinational giants like Novo Nordisk and Eli Lilly, with Novo Nordisk leading the market due to the strong performance of semaglutide [14]. - The second tier consists of domestic leaders such as Huadong Medicine and Innovent Biologics, which are making strides with generic and innovative products [15]. - The third tier features innovative companies focusing on oral formulations and differentiated pipelines [15]. Development Trends - The trend towards multi-target drugs is accelerating, with innovations like dual-target agents showing over 30% improvement in efficacy compared to traditional single-target drugs [18]. - Breakthroughs in oral formulations are changing the market dynamics, with expectations that oral GLP-1RA will capture over 30% of the market share by 2028 [19]. - The expansion of indications for GLP-1RA is rapidly progressing, with ongoing research into applications for non-alcoholic fatty liver disease and Alzheimer's disease [20].