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瘦了又胖,减肥药能根治「体重反弹」么?
36氪·2025-03-12 13:44

Core Viewpoint - The article discusses the challenges of weight management and the phenomenon of weight regain after dieting, emphasizing the need for innovative solutions in the weight loss industry to combat this issue [1][2][6]. Group 1: Weight Management Initiatives - The National Health Commission of China has launched a three-year "Weight Management Year" initiative aimed at reducing weight and controlling chronic diseases [1]. - The concept of "metabolic memory" explains why individuals often regain weight after losing it, as the body tends to remember previous weight levels [2][6]. Group 2: Current Market Dynamics - The weight loss market is seeing significant sales, with drugs like semaglutide generating annual revenues of $28.3 billion [3]. - Major pharmaceutical companies, including Novo Nordisk and Eli Lilly, are focusing on developing new mechanisms and improving existing products to address muscle loss and weight regain during weight loss [2][10]. Group 3: Challenges in Weight Loss - Many weight loss methods lead to muscle loss, which can decrease the basal metabolic rate and exacerbate weight regain after stopping treatment [10]. - A study published in the Journal of the American Medical Association indicated that participants who stopped taking the weight loss drug tirzepatide regained an average of 14% of their lost weight within a year [8]. Group 4: Innovative Solutions and Research - Companies are exploring new drug targets and combination therapies to enhance weight loss while preserving muscle mass [10][11]. - The UK company NodThera is investigating an anti-inflammatory approach to weight loss, which has attracted interest from major players like Novo Nordisk [11]. Group 5: Long-term Weight Management Strategies - Experts recommend sustainable lifestyle changes, including balanced diets and regular exercise, as more effective long-term strategies for weight management compared to quick fixes [12][13]. - A comprehensive approach to weight management may involve a treatment cycle lasting over 20 months, focusing on identifying causes of obesity and designing personalized weight loss strategies [12].