Top 5 DeFi Crypto That Could RALLY in 2025: Insider Picks

DeFi Market Overview - SEC is considering policies to exempt DeFi protocols from regulatory barriers, leading to a rally in DeFi tokens [1] - The industry highlights five DeFi cryptos with potential for significant portfolio growth [1] Uniswap (UNI) - Uniswap is a decentralized exchange (DEX) on Ethereum, supporting ERC20 tokens and EVM chains [1] - UNI has a total supply of 1 billion tokens, with approximately 600 million in circulation; 15% was airdropped to early users [1] - UNI could potentially reach $100, resulting in a 13x increase from current prices and a market cap of roughly $63 billion [1] Aave (AAVE) - Aave is a lending and borrowing platform for crypto assets without KYC, credit scores, or intermediaries, having raised $49 million in funding [2] - Aave reached over $40 billion in total value locked (TVL), driven by new user deposits [2] - Aave's all-time high of $670 would mean a 2.5x gain, and a rally to $1,000 is possible, translating to a 4x gain and a $16 billion market cap [2] Sky (formerly Maker DAO) - Sky aims to further decentralize the Maker protocol into independent subdows (Sky Stars) [2] - One MKR can be converted to 24,000 Sky tokens, potentially allowing for greater participation and decentralized governance [2] - Sky has a market cap of $1.7 billion, with a potential to increase three times to match MKR's previous high, and a $1 target would give it a market cap of around $23 billion (12x gain) [2] - There are 28.5 billion Sky tokens in total with 21.3 billion in circulation, and 7.1 billion USDS tokens have been minted [2] Jito (JTO) - Jito is a liquid staking and MEV capturing protocol on Solana, having raised $12.1 million [2] - JTO became the largest protocol on Solana with $1.44 billion in TVL and peaked at nearly $4 billion in January 2025 [3] - If JTO breaks above $3, it could reach its previous all-time high of $5.5 (2.5x gain), with a potential target of $10 translating to a $3.4 billion market cap (4x gain) [3] - Approximately a third of the 1 billion JTO tokens are currently in circulation [3] Radium (RAY) - Radium is an AMM DEX on Solana, having raised around $33 million [3] - Radium has over $1.7 billion in TVL, down from its peak of just under $3 billion [3] - If RAY reaches its previous all-time high of $17, it would translate to a 7x gain, and a push to $50 is possible, giving it a market cap of around $13.4 billion (20x gain) [3] - Just over 267 million of the 555 million RAY tokens are in circulation [3]