Nasdaq notches fresh record high, how to play the GLP-1 pharma space

Market Performance & Indices - NASDAQ 100 and the composite indices reached record highs [2] - S&P 500 missed a new record by 18 or 28 cents [2] - The Dow increased by 1 and a third percent for the week [2] - NASDAQ was up almost 4% [3] Sector & Stock Movements - Tech sector led gains, up almost 1%, followed by financials and healthcare [3] - Utilities and real estate sectors posted losses for the day due to interest rate sensitivity [3] - Apple increased by 4 and a quarter percent, Alphabet up 2 and a half percent, and Tesla up over 2% [4] - UnitedHealth was up 2 and a half percent, while McDonald's slid about three-quarters of a percent, and IBM was down about 1 and a half percent [5] - Uber decreased by 3%, while FedEx and United Airlines both increased by about 1 and a half percent [6] - Micron increased by about 6%, while Microchip decreased by 6 and a half percent, and Super Micro decreased by about 4% [6] Economic Factors & Tariffs - Tariffs are expected to slow things down, with about two-thirds of the Liberation Day tariffs going into effect [10] - Inflation remaining stubbornly above 3% on CPI, coupled with a weakening consumer and labor market, could lead to a 10% to 20% correction [15] - Effective tariff rates are expected to increase by another 8% based on announced deals [23] Pharmaceutical Sector - Eli Lilly's stock decreased after the Orphaglyron attain one study showed 11-12% weight loss at 72 weeks, lower than the expected 14% [50] - Eli Lilly raised its full-year guidance, driven by Mangaro and Zetbound performance in the US and XUS [52] - Gilead is innovating in the convenience space with a twice-yearly injection for HIV prevention [60]