Genetically engineering mouse DNA could be key to curbing Lyme disease

Project Overview - Scientists are exploring genetic engineering to reduce Lyme disease transmission by modifying wild mice to be immune to Lyme bacteria [2][3][8][9] - The project, "Mice Against Ticks," aims to interrupt the Lyme disease cycle without harming the mouse population or the broader ecosystem [9][10][17] Scientific Approach - Researchers are injecting an antibody gene into mouse embryos using CRISPR technology to create heritable immunity to Lyme disease [18][20][21] - The engineered mice would pass on the immunity to their offspring, speeding up evolution to combat the disease [22][23] Community Engagement and Ethical Considerations - The project emphasizes community involvement and transparency, seeking local approval before releasing engineered mice on Nantucket [3][23][24] - Concerns include potential unintended consequences on the ecosystem and the ethical implications of altering wild populations [26][28][29][30] Implementation and Future Plans - Initial plans involve releasing thousands of engineered mice on Nantucket, starting in winter when the native mouse population is low [23] - A small field trial on a private island is planned to assess ecological impacts before broader implementation [32] Lyme Disease Impact - Lyme disease affects 15% of Nantucket residents and can lead to severe health issues if untreated [4][13] - The island's environment, engineered by conservation efforts and deer introduction, has contributed to the high prevalence of Lyme disease [15][16]