The Gene Editing Dilemma: Where Science Meets Society | Chloe Richards | TEDxKings College School

Ethical Concerns & Risks - The gene editing experiment by He Jiankui was globally condemned as unsafe, reckless, and ethically indefensible [4] - The experiment lacked sufficient consent, with a 23-page document written in English, a non-native language for many participants, and contained technical terms [5][6] - CCR5 gene, targeted in the experiment, has pleiotropic effects, potentially increasing susceptibility to other viruses like influenza [5] - Gene editing raises concerns about potential use for enhancement, creating a two-tiered society [9] - Eradicating genetically inherited diseases may imply that the lives of those living with these conditions are less valuable [10] Gene Editing Technology & Applications - CRISPR technology involves a guide RNA molecule binding to target DNA, directing the CAS9 enzyme to create a double-stranded break [2] - Cell repair mechanisms can replace or add nucleotides, disabling genes or introducing new DNA sequences [3] - Mitochondrial replacement therapy (MRT) is an ethically acceptable form of gene therapy, preventing mutated mitochondrial DNA from being passed on [8] - Gene editing advancements are being explored for treating Huntington's disease [10] Public Opinion & Future Outlook - A survey indicated that 76% of the British population does not support a complete ban on gene editing technology [7] - Gene editing is an undeniable part of the future, requiring societal discussion and informed opinions [10][12]