凯氏定氮法VS质谱法：千亿重组胶原蛋白背后的分析仪器之争？

Core Viewpoint - The recent controversy surrounding the detection of collagen content in cosmetic ingredients highlights the need for improved technical adaptability and the establishment of standardized testing protocols within the industry [1][2]. Group 1: Industry Trends and Market Potential - The "14th Five-Year Plan" for bio-economy development emphasizes synthetic biology as a strategic frontier technology, encouraging its application in health and beauty sectors [2]. - The recombinant collagen market in China is projected to reach 108.3 billion yuan by 2027, with a compound annual growth rate (CAGR) of 44.93% from 2023 to 2027, driven by policy incentives and technological advancements [2]. - Established players like Juzhi Bio, Jinbo Bio, and Chuangjian Medical are intensifying their R&D and market expansion efforts, while new entrants are also emerging in this high-growth sector [2]. Group 2: Detection Method Controversy - The controversy centers on the choice of detection methods and the lack of standardized protocols, with significant discrepancies in collagen content measurements depending on the method used [2][4]. - Official statements indicate that the collagen content detection methods referenced include mass spectrometry and total protein quantification methods, with the Kjeldahl method being the most likely employed due to its simplicity [4]. - The Kjeldahl method, while widely used, has limitations as it cannot distinguish the nitrogen source, raising concerns about its accuracy in complex formulations [5]. Group 3: Technical Challenges and Standardization - The complexity of cosmetic formulations necessitates advanced detection methods that can provide high sensitivity and selectivity, as conventional methods often fall short [8]. - The absence of a unified national standard in China's cosmetics industry leads to inconsistent testing results, as different institutions rely on varying standards, creating potential risks [8][9]. - The analysis and detection industry must take a more active role in standard-setting and method validation to ensure reliable and transparent testing processes in the rapidly evolving fields of bio-materials and cosmetics [9].