Core Viewpoint - The article highlights the significant innovations introduced by Bruker at the ASMS 2025 conference, particularly the launch of the timsOmni™, timsMetabo™, and proteoElute™ systems, which are expected to advance research in proteomics and metabolomics significantly [1][2][3]. Group A: timsOmni™ Mass Spectrometry System - The timsOmni™ system is a revolutionary mass spectrometry platform designed for in-depth analysis of biomolecular structures, particularly in the fields of scientific research, drug development, clinical studies, and biopharmaceutical quality control [3]. - It features a multi-modal eXd capture technology that allows precise electronic energy control, ion accumulation, and adjustable reaction times, supporting various fragmentation methods for comprehensive structural information [3][5]. - The system is particularly adept at identifying low-abundance protein variants associated with diseases such as cancer and neurodegenerative disorders, enhancing the understanding of protein function and pathology [5][7]. Group B: OmniScape™ Software - OmniScape™ is a new generation protein sequencing analysis software that supports data analysis from the timsOmni™ system, offering advanced algorithms for complex spectrum deconvolution and protein identification [5][9]. - It transforms complex eXd fragmentation spectra into biologically relevant information, facilitating the study of functional proteomics [5][9]. Group C: timsMetabo™ Mass Spectrometry System - The timsMetabo™ system is a high-performance 4D mass spectrometry instrument that enhances small molecule analysis and integrates seamlessly with high-sensitivity proteomics [10][12]. - It introduces the "MoRE" scanning mode, which significantly improves sensitivity, separation capability, and annotation reliability for metabolomics studies [12][14]. - The system generates unique digital metabolomic profiles for each sample, enhancing the reliability of analysis results and supporting AI applications in metabolomics [14]. Group D: proteoElute™ Nanoflow Liquid Chromatography System - The proteoElute™ system is designed to provide sensitive and robust solutions for proteomics, particularly in analyzing protein variants and complex biological samples [15][16]. - It features the TwinScape™ technology for real-time system monitoring and proactive maintenance, ensuring reliable performance even with low sample volumes [16]. - The new PepSep® Advanced chromatography column enhances peak shape and resolution, improving peptide and protein identification rates by approximately 20% and 10%, respectively [17].
布鲁克发布四大新品:聚焦质谱与色谱创新