天津工生所吴信研究员在技术驱动非粮原料生物制造微生物蛋白的前沿综述

Core Viewpoint - The article emphasizes the transformative potential of synthetic biology in addressing sustainability challenges in traditional agricultural protein production, particularly through the development of microbial protein from non-grain raw materials [1][2]. Group 1: Technological Innovations - The research team has made significant breakthroughs in the use of methanol as a renewable C1 compound, enhancing the efficiency of converting methanol into single-cell protein through metabolic engineering and genomic perturbation [2]. - Innovations in gas-phase non-grain microbial protein production include the construction of a light-dark energy adapter in E. coli, enabling light-driven CO2 assimilation [2]. - The team has developed a machine learning model to decode the composition of degrading enzyme systems based on the structural characteristics of lignocellulose, facilitating the production of microbial protein from agricultural waste [2]. Group 2: Economic and Environmental Impact - The innovative conversion models not only enhance the economic value of agricultural waste but also pave the way for the industrial-scale biosynthesis of microbial protein from these resources, achieving a dual benefit of resource utilization [2]. - The research highlights the integration of synthetic biology and interdisciplinary innovation as a driving force for sustainable protein production, contributing to food security and carbon neutrality goals [6]. Group 3: Future Research Directions - Future research will focus on the super-evolutionary design of chassis cells, the closed-loop integration of negative carbon manufacturing systems, and the construction of AI-driven intelligent bio-manufacturing platforms [6].