世界首例！基因编辑猪肺，成功移植人体

Core Viewpoint - The research team from China has successfully performed the world's first gene-edited pig lung transplant into a brain-dead human, marking a significant milestone in the field of xenotransplantation and addressing the shortage of organ donors [1][2]. Group 1: Research Details - The study involved the transplantation of a left lung from a genetically edited Bama pig into a brain-dead individual, simulating a common clinical single-lung transplant procedure [1]. - The donor pig underwent six genetic modifications to reduce the risk of immune rejection after the organ was transplanted into a human [1]. - Post-surgery monitoring indicated that the transplanted lung maintained ventilation and gas exchange functions for nine days without acute rejection, and no active infection was detected during this period [1]. Group 2: Implications and Future Directions - The increasing global demand for organ transplants has led to xenotransplantation being viewed as a potential solution to the donor shortage crisis [1]. - The research team plans to further optimize gene editing strategies and anti-rejection treatment protocols to extend the survival and functionality of transplanted organs [1]. - The team aims to apply their independently developed non-invasive technology in future xenotransplantation trials to minimize mechanical ventilation damage to the donor lung, facilitating the transition of xenotransplantation to clinical applications [1]. Group 3: Ethical Considerations - The research adhered to national laws, regulations, and ethical guidelines, receiving approval from the hospital's ethics committee and other oversight bodies [2]. - The brain-dead subject's family consented to participate in the study to support medical advancement, and the study was concluded at the family's request on the ninth day [2]. Group 4: Expert Opinions - International experts have praised the research, noting that previous xenotransplantation trials were limited to kidneys, hearts, and livers, with lung transplantation presenting unique challenges due to its physiological balance and exposure to external air [2]. - The director of Spain's National Transplant Organization highlighted the achievement as a milestone in the field of xenotransplantation [2].