世界首例！中国团队将基因编辑猪肺成功移植人体

Core Viewpoint - The research team from China has successfully performed the world's first gene-edited pig lung transplant into a brain-dead human, marking a significant milestone in the field of xenotransplantation and potentially addressing the shortage of organ donors [3][4]. Group 1: Research Details - The transplant involved a left lung from a genetically edited Bama pig, which underwent six gene edits to reduce immune rejection risks [3]. - Post-surgery monitoring indicated that the transplanted lung maintained ventilation and gas exchange functions for nine days without acute rejection or active infection [3][4]. - The research was conducted under strict adherence to national laws and ethical guidelines, with the brain-dead subject's family consenting to the study [4]. Group 2: Expert Opinions - International experts have praised the achievement, highlighting the challenges of lung transplantation compared to other organs due to the delicate physiological balance and exposure to external air [5]. - The director of Spain's National Transplant Organization described the Chinese team's work as a milestone in the field of xenotransplantation [5]. Group 3: Future Directions - The research team plans to optimize gene editing strategies and anti-rejection treatments to extend the survival and functionality of transplanted organs [3]. - There are intentions to apply a self-developed non-invasive technique in future xenotransplantation trials to minimize damage to the donor lung [3].