让坂口志文获诺贝尔奖的调节性T细胞是什么

Core Viewpoint - The 2025 Nobel Prize in Physiology or Medicine is awarded to Shimon Sakaguchi, Mary E. Brunkow, and Fred Ramsdell for their discovery of regulatory T cells that suppress abnormal immune responses, paving the way for new therapies for autoimmune diseases, allergies, and cancer [2][4]. Group 1 - Shimon Sakaguchi discovered regulatory T cells that can inhibit immune responses against the body’s own cells, preventing autoimmune diseases [2][4]. - The award recognizes the discovery of peripheral immune suppression, which is crucial for understanding immune system regulation [4]. - Sakaguchi's research began after he read a report on thymectomized mice showing autoimmune disease symptoms, leading him to hypothesize the existence of a T cell type that could control immune overactivity [4][5]. Group 2 - Despite skepticism from other researchers, Sakaguchi proved the existence of regulatory T cells in 1985 and identified key genes involved in their function by 1995 [5]. - He founded RegCell, a startup in California, in 2016 to promote the application of his research findings [5]. - The potential applications of manipulating regulatory T cells include treating autoimmune diseases and preventing organ transplant rejection [7]. Group 3 - The Nobel Prize ceremony will take place on December 10 in Stockholm, Sweden, with a total prize amount of 11 million Swedish Krona to be shared among the three laureates [7]. - Sakaguchi has received multiple prestigious awards throughout his career, including the Keio Medical Prize in 2008 and the Robert Koch Prize in 2020 [8].