罗氏宣布“最快”测序仪定价，凭什么卖这么贵？

Core Insights - Roche has launched the high-throughput sequencer AXELIOS priced at $750,000, challenging Illumina's market position, with competition focusing on consumable pricing and technological ecosystem [1][6]. Product Details - AXELIOS utilizes Sequencing by Expansion (SBX) technology, which combines synthetic dNTPs (X-NTPs) and nanopore sequencing. The process involves enzymatic reactions to synthesize extended molecules (Xpandomers) that are over 50 times longer than the original DNA fragments, allowing for efficient sequencing [4]. - The average read length for SBX Duplex is around 240 base pairs, with over 95% of reads exceeding 150 base pairs, indicating high sequencing accuracy and throughput [4]. Industry Impact - Roche's participation and strategy signify a new phase in the high-throughput sequencing market, with the competitive landscape largely dependent on consumable pricing and the development of a comprehensive ecosystem [6]. - At the ASHG conference, Roche Sequencing Solutions, in collaboration with Broad Clinical Labs and Boston Children's Hospital, set a new world record for DNA sequencing, completing a human genome sequencing in under 4 hours, surpassing the previous record of 5 hours and 2 minutes [5].