英矽智能更新招股书：AI驱动药物研发，日前与礼来达成总额超1亿美元合作

Core Insights - Insilico Medicine aims to become the first globally to have an AI-enabled drug candidate enter Phase III clinical trials [2][4] - The company has developed a dual-engine business model focusing on both AI platform licensing and internal pipeline development [6] Company Overview - Insilico Medicine, founded in 2014, is a global AI-driven biotech company that utilizes its Pharma.AI platform for drug discovery and development [2] - The company has expanded the application of its AI technology to various sectors, including advanced materials, agriculture, nutrition products, and veterinary medicine [2] Pipeline and Clinical Progress - The core asset, Rentosertib (ISM001-055), is a first-in-class candidate for idiopathic pulmonary fibrosis (IPF) and has shown positive results in Phase IIa clinical trials in China [3] - The drug has received breakthrough therapy designation from the Center for Drug Evaluation (CDE) in China, which may expedite its clinical development and review process [3][4] - Insilico Medicine has generated over 20 clinical or IND-stage assets through its Pharma.AI platform, with three assets licensed to international pharmaceutical companies, totaling over $2 billion in contract value [4] Financial Performance - Revenue projections for Insilico Medicine from 2022 to 2024 are $30.15 million, $51.18 million, and $85.83 million, respectively, with gross margins increasing from 63.4% to 90.4% [5] - The net loss is expected to decrease significantly from $222 million in 2022 to $17.1 million in 2024 [5] Funding and Use of Proceeds - As of June 30, 2025, the company's cash and equivalents increased from approximately $126 million at the end of 2024 to about $213 million, primarily due to a Series E financing round [7] - The net proceeds from the IPO will be used for further clinical development of key pipeline candidates, development of new generative AI models, and expansion of automated laboratories [7]