“流感神药”说明书为啥这么长长长长长长

Core Viewpoint - The article discusses the extensive length and complexity of drug instruction leaflets, highlighting the challenges faced by patients in understanding them and the implications for pharmaceutical companies and healthcare professionals [2][5][12]. Group 1: Length and Complexity of Instruction Leaflets - Roche's Marbofloxacin has an instruction leaflet that is 60 centimeters long, with the longest in China reaching 1 meter [2][12]. - The instruction leaflets for some drugs, like Merck's Pembrolizumab, can cover an area of approximately 2 square meters, containing extensive information due to multiple indications and clinical trial data [6][12]. - The complexity of these leaflets often leads to confusion among patients, with some expressing that the adverse effects listed seem more daunting than the illness itself [5][16]. Group 2: Regulatory and Legal Framework - The content and format of drug instruction leaflets are governed by the 2006 National Drug Instruction and Label Management Regulations, which require comprehensive safety and efficacy data [8][12]. - The National Medical Products Administration (NMPA) has established guidelines that dictate the inclusion of 26 essential items in drug leaflets, such as indications, dosage, adverse reactions, and contraindications [8][12]. Group 3: Professional Perspective - Healthcare professionals emphasize that detailed instruction leaflets are beneficial for ensuring patient safety and informed prescribing practices [11][12]. - The length of a leaflet often correlates with the thoroughness of the drug's research, which can help healthcare providers make informed decisions [11][12]. Group 4: Patient Accessibility and Adaptation - There is a growing concern regarding the readability of instruction leaflets, particularly for elderly patients, prompting initiatives for larger print and simplified versions [17][18]. - Some pharmaceutical companies are exploring the use of QR codes to provide electronic versions of leaflets that can be easily accessed and read [18][19].