蔡磊发布公开信

Core Viewpoint - The article emphasizes the urgent need for breakthroughs in the treatment of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, highlighting the hope and determination of patients and researchers in the face of this devastating illness [2][3]. Group 1: Patient Experience and Advocacy - The letter from a patient, Cai Lei, illustrates the severe impact of ALS, describing his physical limitations and the emotional toll of the disease, while expressing a strong desire for hope and breakthroughs in treatment [2]. - Cai Lei's experience reflects the broader struggle of ALS patients, who often face a grim prognosis with an average survival of only 2 to 5 years, and the lack of effective treatments available globally [4]. Group 2: Research and Collaboration - In 2025, Cai Lei's team engaged with over 60 top research teams and more than 50 biotech companies, facilitating nearly 100 collaborative research projects aimed at ALS, resulting in 15 drug pipelines and treatment technologies [3][4]. - The establishment of the "Gradual Recovery Mutual Assistance Home" data platform has registered over 18,000 ALS patients, creating a significant patient cohort for research purposes [4]. Group 3: Technological Advancements - The rapid development of artificial intelligence has significantly enhanced research capabilities, allowing the team to analyze nearly 40,000 ALS research papers and rank hundreds of drugs based on preclinical trial results, vastly improving research efficiency [4]. - The team aims to leverage cutting-edge technologies, such as brain-machine interfaces and embodied intelligence, to develop nursing robots that can assist ALS patients, thereby alleviating the dual burden on families [6][7]. Group 4: Community and Support - Cai Lei maintains over 40 support groups for ALS patients, fostering a sense of community and shared experience among individuals facing similar challenges [5]. - The support from family, colleagues, and society has been crucial in providing emotional strength and motivation for ongoing research and advocacy efforts [5].