好文推荐！谭天伟院士等：中国生物制造关键技术进展与未来趋势

Core Viewpoint - Biomanufacturing is a crucial technology path for achieving green, low-carbon, and sustainable development, evolving rapidly across the entire industry chain from raw materials to products [3][4]. Group 1: Key Technological Development Trends in Biomanufacturing - Biomanufacturing is transitioning from traditional fermentation-driven methods to intelligent and bio-design-driven manufacturing paradigms [4]. - The raw material system in biomanufacturing is diversifying from grain dependence to non-grain biomass, alleviating competition for land and resources [8]. - High-performance strains and enzymes are evolving towards precision and intelligence, with advancements in gene editing technologies like CRISPR facilitating rapid development [9][10]. Group 2: Challenges in China's Biomanufacturing - China's biomanufacturing heavily relies on starch-based food resources, with about 90% of primary raw materials sourced from crops like corn, leading to resource conflicts [17]. - There is a significant shortfall in the autonomous control of microbial strains, with a high dependency on foreign resources for key industrial strains and enzyme preparations [18]. - The design of biocatalysts and underlying technologies in China is lagging, relying on foreign-developed algorithms and platforms for enzyme design [20]. Group 3: Future Key Technological Development Directions - Focus on developing efficient conversion technologies for one-carbon raw materials and utilizing non-grain biomass resources [26]. - Emphasize intelligent design and creation of industrial enzymes and strains, leveraging AI and big data for precise discovery and development [28]. - Establish smart cell factories and precise bioprocessing technologies, integrating real-time monitoring and AI-driven decision-making [30]. Group 4: Product System Expansion Driven by Biomanufacturing - Biomanufacturing is expected to drive the development of high-energy-density biofuels, sustainable materials, and innovative food products, contributing to economic benefits and social value [32]. - In the energy sector, focus on renewable alternatives like bio-aviation fuel and bio-hydrogen [33]. - In the chemical sector, breakthroughs in bio-based platform compounds are essential for supporting decarbonization efforts in the chemical industry [33].