Core Viewpoint - N2OFF, Inc. has successfully completed the merger with MitoCareX Bio Ltd., expanding its portfolio into the biotech sector focused on cancer therapeutics [1][3]. Company Overview - N2OFF is a cleantech company primarily engaged in solar energy assets using the RTB (Ready to Build) business model, currently leading four solar projects across three EU countries [5]. - MitoCareX specializes in drug discovery targeting cancer therapeutics through the mitochondrial SLC25 protein family, utilizing its proprietary algorithm MITOLINE for 3D comparative modeling [2]. Merger Details - The acquisition closed on October 20, 2025, with N2OFF purchasing ordinary shares of MitoCareX for $700,000 and acquiring the remaining shares, making MitoCareX a wholly-owned subsidiary [3]. - The agreement stipulates that the sellers will receive 30% of N2OFF's financing proceeds, capped at $1.6 million, for five years, along with milestone-based issuances of up to 25% of N2OFF's common stock [3]. Market Potential - The Global Cancer Therapeutics and Biotherapeutics Market is projected to grow from $211.02 billion in 2025 to $378.62 billion by 2032, with a CAGR of 8.7% [2].

Core Insights - Clearmind Medicine Inc. has announced the publication of a U.S. patent application for a combination therapy involving 5-methoxy-2-aminoindane (MEAI) and N-Acylethanolamines, targeting binge behavior disorders [1][2] - The therapy aims to address various binge behaviors, including excessive alcohol consumption, binge eating, smoking, compulsive shopping, and problematic sexual conduct, by leveraging MEAI's neuroplastic properties [2][3] - The company has filed a total of 13 patents related to its collaboration with SciSparc Ltd., focusing on conditions such as alcohol use disorder, cocaine addiction, obesity, and depression [3][4] Company Overview - Clearmind is a clinical-stage biotech company focused on developing psychedelic-derived therapeutics to address significant health issues, including alcohol use disorder [5] - The company's intellectual property portfolio includes 19 patent families and 31 granted patents, with plans to seek additional patents as warranted [6] Strategic Goals - The CEO of Clearmind emphasized the company's mission to pioneer safe and effective treatments for binge behaviors, aiming to meet unmet needs in addiction medicine [4][8] - The combination of MEAI and PEA is positioned as a potentially safer and more effective treatment option compared to existing therapies [2][4]

Core Viewpoint - SciSparc Ltd. has mutually terminated its planned merger with AutoMax Motors Ltd., concluding a deal aimed at expanding into Israel's automotive market [1][2]. Loan Repayment Terms - AutoMax is required to repay $4.25 million with 9% annual interest by January 1, 2028, and a separate $2 million loan will be repaid in monthly installments of $60,000 starting November 20, 2025, with an 8% annual interest rate [2]. Background on the Merger - The merger was initially agreed upon in April 2024, with plans for SciSparc to acquire AutoMax through a reverse merger structure. The deal received approval from both companies' shareholders in 2025 [2]. Strategic Focus After Termination - Following the cancellation of the merger, SciSparc will continue to concentrate on its pipeline of treatments for central nervous system disorders and advance drug discovery using quantum algorithms [3]. Price Action - SciSparc shares experienced a premarket increase of 2.32%, trading at $4.86 [4].

Core Insights - Premarket trading is showing notable activity with significant price movements indicating potential trading opportunities before the market opens [1] Premarket Gainers - SciSparc Ltd. (SPRC) is up 41% at $6.32 - Wolfspeed, Inc. (WOLF) is up 22% at $26.50 - Innovation Beverage Group Limited (IBG) is up 14% at $3.60 - Genasys Inc. (GNSS) is up 12% at $2.52 - Tamboran Resources Corporation (TBN) is up 9% at $24.84 - Fitell Corporation (FTEL) is up 8% at $6.09 - Zura Bio Limited (ZURA) is up 8% at $3.25 - Phio Pharmaceuticals Corp. (PHIO) is up 8% at $2.60 - AVITA Medical, Inc. (RCEL) is up 7% at $5.77 - Next Technology Holding Inc. (NXTT) is up 5% at $24.00 [3] Premarket Losers - Applied DNA Sciences, Inc. (APDN) is down 26% at $3.87 - Epsium Enterprise Limited (EPSM) is down 23% at $18.79 - Artelo Biosciences, Inc. (ARTL) is down 21% at $4.60 - Boqii Holding Limited (BQ) is down 14% at $8.52 - Top KingWin Ltd (WAI) is down 13% at $4.02 - bioAffinity Technologies, Inc. (BIAF) is down 13% at $2.82 - Firefly Aerospace Inc. (FLY) is down 12% at $36.96 - JFB Construction Holdings (JFB) is down 12% at $11.14 - Akanda Corp. (AKAN) is down 9% at $4.31 - Energy Fuels Inc. (UUUU) is down 6% at $15.41 [4]

Company Overview - Wolfspeed, Inc. announced a reorganization plan that will reduce its debt by 70%, from $6.5 billion to $2 billion, and cut interest payments by approximately 60% [1] - The company will reincorporate from North Carolina to Delaware as part of the reorganization process [1] - Following the announcement, Wolfspeed shares surged by 50.9% to $32.63 in pre-market trading [1] Market Movements - Sunrise New Energy Co., Ltd. saw a significant increase of 97% to $1.77 after its subsidiary was granted a U.S. patent for lithium-ion battery anode material [5] - Vivakor, Inc. experienced a 67% rise to $0.4479 after signing a term sheet for up to $23 million in capital [5] - SciSparc Ltd. gained 45.7% to $6.49 following the approval of an acquisition by N2OFF stockholders [5] - Maison Solutions Inc. jumped 23.2% to $1.38 after securing a private placement of up to $70 million [5] Declines in Pre-Market Trading - Valneva SE fell 7.9% to $11.81 despite reporting a 95% antibody seroresponse sustained four years after a single dose [5] - Epsium Enterprise Limited declined 24.3% to $18.60 after a previous drop of 30% [5] - Artelo Biosciences, Inc. saw a decline of 23.1% to $4.50 following a proposed public offering announcement [5] - Energy Fuels Inc. fell 6.4% to $15.47 after announcing a proposed $550 million private offering of convertible senior notes [5]

Core Insights - Premarket trading is showing notable activity with significant price movements indicating potential trading opportunities before the market opens [1] Premarket Gainers - Top KingWin Ltd (WAI) has increased by 79% to $5.68 - Robo.ai Inc. (AIIO) is up 16% at $2.84 - Amplify Energy Corp. (AMPY) has risen by 12% to $6.53 - Diginex Limited (DGNX) is up 9% at $14.50 - MasterBrand, Inc. (MBC) has increased by 9% to $14.15 - GLOBALFOUNDRIES Inc. (GFS) is up 8% at $35.69 - Crinetics Pharmaceuticals, Inc. (CRNX) has risen by 7% to $38.50 - Aquestive Therapeutics, Inc. (AQST) is up 7% at $5.68 - American Woodmark Corporation (AMWD) has increased by 6% to $69.40 - NLS Pharmaceutics AG (NLSP) is up 5% at $2.17 [3] Premarket Losers - Concentrix Corporation (CNXC) has decreased by 21% to $43.05 - N2OFF, Inc. (NITO) is down 20% at $4.40 - SciSparc Ltd. (SPRC) has fallen by 16% to $5.11 - Legacy Education Inc. (LGCY) is down 13% at $10.68 - DarioHealth Corp. (DRIO) has decreased by 12% to $11.99 - AlphaTON Capital Corp. (ATON) is down 12% at $5.50 - SHF Holdings, Inc. (SHFS) has fallen by 10% to $6.20 - Fusion Fuel Green PLC (HTOO) is down 8% at $4.55 - Linkage Global Inc (LGCB) has decreased by 8% to $2.19 - PepGen Inc. (PEPG) is down 7% at $5.42 [4]

Core Viewpoint - N2OFF, Inc. has announced the approval of the acquisition of MitoCareX Bio Ltd., a biotech company focused on cancer therapeutics, by its stockholders during a special meeting held on September 25, 2025 [1] Company Overview - N2OFF, Inc. is a cleantech company primarily engaged in solar energy assets using the Ready to Build (RTB) business model, currently leading four solar projects across three EU countries [6] - The company also controls approximately 98% of Save Foods Ltd., which focuses on post-harvest treatments for fruits and vegetables [7] Acquisition Details - The acquisition agreement involves N2OFF purchasing 6,622 shares from SciSparc Ltd. for $700,000 and exchanging additional shares for 40% of MitoCareX's fully diluted capital stock [3] - The Sellers will receive 30% of N2OFF's financing proceeds, capped at $1.6 million, for five years, and may be entitled to milestone-based issuances of up to 25% of N2OFF's common stock [3][4] - N2OFF is committed to financially support MitoCareX with an initial cash investment of $1,000,000 during the first two years post-acquisition [4] MitoCareX Overview - MitoCareX specializes in developing novel therapies for hard-to-treat cancers by targeting the mitochondrial SLC25 protein family [2] - The global Cancer Therapeutics and Biotherapeutics market was valued at $194.1 billion in 2024 and is projected to reach $344.1 billion by 2031, indicating significant growth potential in this sector [2]

Market Overview - U.S. stocks experienced a decline, with the Nasdaq Composite falling over 1% on Thursday, while the Dow decreased by 0.64% to 45,824.16 and the S&P 500 dropped 1% to 6,571.28 [1] - Energy shares increased by 0.5%, while health care stocks fell by 1.4% on the same day [1] Company Performance - Accenture (NYSE: ACN) reported better-than-expected fourth-quarter 2025 results, with earnings of $3.03 per share, surpassing the analyst consensus estimate of $2.96, and sales of $17.60 billion, slightly exceeding the estimate of $17.36 billion [2] Commodity Market - Oil prices decreased by 0.2% to $64.88, while gold also fell by 0.2% to $3,761.50. Silver prices rose by 1.2% to $44.725, and copper prices dropped by 1% to $4.7660 [5] European Market - European shares were lower, with the eurozone's STOXX 600 falling by 0.52%, Spain's IBEX 35 Index down by 0.18%, London's FTSE 100 down by 0.24%, Germany's DAX 40 dipping by 0.62%, and France's CAC 40 falling by 0.46% [6] Asian Market - Asian markets closed mostly lower, with Japan's Nikkei 225 gaining 0.27%, while Hong Kong's Hang Seng declined by 0.13%, China's Shanghai Composite fell by 0.01%, and India's BSE Sensex decreased by 0.68% [7] Notable Stock Movements - PepGen Inc. (NASDAQ: PEPG) shares surged by 89% to $5.03 following the announcement of a $100 million public offering at $3.20 per share [8] - SciSparc Ltd. (NASDAQ: SPRC) shares increased by 101% to $7.71 after announcing a quantum computing-enabled 3D protein modeling initiative [8] - Plus Therapeutics, Inc. (NASDAQ: PSTV) shares rose by 30% to $0.5264 after securing a national coverage agreement with UnitedHealthcare [8] - Stitch Fix, Inc. (NASDAQ: SFIX) shares dropped by 14% to $4.88 after releasing fourth-quarter results [8] - CarMax, Inc. (NYSE: KMX) shares fell by 23% to $43.86 after reporting second-quarter EPS and sales below estimates [8] - Cemtrex, Inc. (NASDAQ: CETX) shares decreased by 31% to $0.4359 following a 1-for-15 reverse stock split approval [8] Economic Indicators - U.S. wholesale inventories declined by 0.2% month-over-month to $898.8 billion in August, contrary to market expectations of a 0.1% increase [11] - U.S. durable goods orders rose by 2.9% month-over-month to $312.1 billion in August, compared to a revised 2.7% decline in July [11] - The U.S. trade deficit in goods decreased by $17.3 billion month-over-month to $85.5 billion in August, better than market estimates [11] - Initial jobless claims fell by 14,000 to 218,000 in the third week of September, below market expectations [11] - The U.S. economy grew at an annualized rate of 3.8% in the second quarter, an increase from the previous estimate of 3.3% [11]

Market Overview - U.S. stocks traded lower, with the Nasdaq Composite falling more than 1% on Thursday, Dow down 0.64% to 45,824.16, NASDAQ down 1.19% to 22,229.54, and S&P 500 down 1% to 6,571.28 [1] - Energy shares increased by 0.5%, while health care stocks decreased by 1.4% [1] Company Earnings - Accenture (NYSE: ACN) reported better-than-expected fourth-quarter 2025 results, with earnings of $3.03 per share, exceeding the analyst consensus estimate of $2.96, and sales of $17.60 billion, slightly above the consensus estimate of $17.36 billion [2] Stock Movements - PepGen Inc. (NASDAQ: PEPG) shares surged 89% to $5.03 after announcing a $100 million public offering at $3.20 per share [8] - SciSparc Ltd. (NASDAQ: SPRC) shares increased by 101% to $7.71 following the announcement of a quantum computing-enabled 3D protein modeling initiative [8] - Plus Therapeutics, Inc. (NASDAQ: PSTV) shares rose 30% to $0.5264 after a national coverage agreement with UnitedHealthcare [8] - Stitch Fix, Inc. (NASDAQ: SFIX) shares fell 14% to $4.88 after releasing fourth-quarter results [8] - CarMax, Inc. (NYSE: KMX) shares dropped 23% to $43.86 after reporting second-quarter EPS and sales below estimates [8] - Cemtrex, Inc. (NASDAQ: CETX) shares declined 31% to $0.4359 after a 1-for-15 reverse stock split approval [8] Commodity Prices - Oil traded down 0.2% to $64.88, gold down 0.2% to $3,761.50, silver up 1.2% to $44.725, and copper down 1% to $4.7660 [5] European Market Performance - European shares were lower, with the eurozone's STOXX 600 down 0.52%, Spain's IBEX 35 down 0.18%, London's FTSE 100 down 0.24%, Germany's DAX 40 down 0.62%, and France's CAC 40 down 0.46% [6] Asian Market Performance - Asian markets closed mostly lower, with Japan's Nikkei 225 gaining 0.27%, while Hong Kong's Hang Seng declined 0.13%, China's Shanghai Composite fell 0.01%, and India's BSE Sensex fell 0.68% [7] Economic Indicators - U.S. wholesale inventories declined by 0.2% month-over-month to $898.8 billion, against market estimates of a 0.1% increase [11] - U.S. durable goods orders increased by 2.9% month-over-month to $312.1 billion, compared to a revised 2.7% decline in July [11] - The U.S. trade deficit in goods shrank by $17.3 billion month-over-month to $85.5 billion, compared to market estimates of $95.65 billion [11] - Initial jobless claims decreased by 14,000 to 218,000, against market estimates of 235,000 [11] - The U.S. economy grew at an annualized rate of 3.8% in the second quarter, up from 3.3% in the second estimate [11]

Market Overview - U.S. stocks traded lower, with the Nasdaq Composite falling more than 1% on Thursday, while the Dow decreased by 0.50% to 45,889.75 and the S&P 500 dropped 0.94% to 6,575.35 [1] - Consumer staples shares increased by 0.5% on Thursday, contrasting with a 1.5% decline in communication services stocks [1][2] Economic Indicators - Initial jobless claims decreased by 14,000 to 218,000 in the third week of September, better than market estimates of 235,000 [3][12] - U.S. wholesale inventories fell by 0.2% month-over-month to $898.8 billion in August, against expectations of a 0.1% increase [12] - Durable goods orders rose by 2.9% month-over-month to $312.1 billion in August, surpassing market estimates of a 0.5% decline [12] - The U.S. trade deficit in goods narrowed by $17.3 billion to $85.5 billion in August, compared to market estimates of $95.65 billion [12] - The U.S. economy grew at an annualized rate of 3.8% in the second quarter, an increase from the previous estimate of 3.3% [12] Commodity Market - Oil prices decreased by 0.5% to $64.66, while gold fell by 0.1% to $3,766.60 [6] - Silver prices increased by 1.4% to $44.805, whereas copper declined by 0.6% to $4.7865 [6] Company Performance - PepGen Inc. shares surged 107% to $5.51 following the announcement of a $100 million public offering priced at $3.20 per share [10] - SciSparc Ltd. shares rose 79% to $6.86 after announcing a quantum computing-enabled 3D protein modeling initiative [10] - Plus Therapeutics, Inc. shares increased by 40% to $0.5640 due to a national coverage agreement with UnitedHealthcare [10] - SeaStar Medical Holding Corporation shares plummeted 50% to $0.6226 after a recommendation to continue a pivotal trial [10] - Erayak Power Solution Group Inc. shares fell 31% to $0.0493 after a previous jump [10] - Cemtrex, Inc. shares dropped 29% to $0.4470 following the approval of a reverse stock split [10]