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Lilly's once-weekly insulin efsitora alfa demonstrated A1C reduction and a safety profile consistent with daily insulin in multiple Phase 3 trials
Prnewswire· 2025-06-22 18:31
Core Insights - Eli Lilly's investigational once-weekly insulin efsitora alfa has shown promising results in Phase 3 clinical trials, indicating its potential to simplify insulin management for adults with type 2 diabetes [1][8] - The company plans to submit efsitora for regulatory approval by the end of 2025, aiming to enhance treatment options for diabetes patients [8] Study Results - In the QWINT-1 study, efsitora reduced A1C by 1.31% compared to 1.27% for insulin glargine at week 52, demonstrating non-inferiority [2][4] - QWINT-3 showed efsitora reducing A1C by 0.86% compared to 0.75% for insulin degludec at week 26 [2][5] - In QWINT-4, efsitora achieved an A1C reduction of 1.07%, equal to that of insulin glargine at week 26 [2][7] Safety Profile - Efsitora demonstrated a safety profile comparable to daily basal insulins, with approximately 40% fewer hypoglycemic events compared to insulin glargine in QWINT-1 [5][6] - The rates of severe or clinically significant hypoglycemic events per patient-year were 0.50 for efsitora versus 0.88 for insulin glargine at 52 weeks [6][7] Treatment Regimen - The fixed-dose regimen in QWINT-1 consisted of four single-dose titration options, which may facilitate insulin therapy initiation for type 2 diabetes patients [3][10] - Efsitora's once-weekly administration could potentially eliminate over 300 injections per year, reducing the burden of insulin therapy [6][10] Clinical Development - The QWINT Phase 3 clinical program began in 2022, enrolling over 3,000 participants across four global studies [9][10] - The trials included diverse populations from multiple countries, enhancing the robustness of the findings [11][12]
北森控股(09669.HK):经营性现金流转正 AI商业化稳步推进
Ge Long Hui· 2025-06-22 18:25
机构:中金公司 研究员:张潇丹/赵丽萍 FY2025 业绩基本符合市场预期 北森控股公布FY2025 业绩:收入同比增长10.6%至9.45 亿元,经调整归母净亏损由上年1.05 亿元收窄 至2,910 万元,均落于公司此前发布的盈喜区间,基本符合市场预期。此外,公司于2025 年1 月15 日公 告,宣布收购酷学院100%股权,以进一步强化eLearning(即在线学习)市场布局。 发展趋势 风险 宏观经济疲软,产品迭代、技术应用不及预期。 展望FY2026,我们预计伴随业务规模效应持续释放,公司有望实现全年经调整净利润层面的扭亏为 盈。 盈利预测与估值 维持FY2026 收入预测基本不变;考虑毛利率改善及费控成效好于预期,将FY2026 经调整归母净利润 由-1,811 万元上调至2,251 万元。引入FY2027收入预测12.69 亿元和经调整归母净利润预测1.00 亿元。 维持跑赢行业评级;鉴于估值中枢上行以及AI 场景赋能下中长期更为乐观的增长预期,上调目标价 130%至11.5 港元(将估值切换至FY26;将市销率倍数由3.4 倍上调至7.0 倍)。目前公司交易于5.4 倍 FY26 市销率,对应 ...
狂飙的超标“外卖电动车”:保险赔付难,引发诉讼多,骑手和受害者权益如何保障
Xin Lang Cai Jing· 2025-06-22 18:23
"外卖员的电动车,基本上都是机动车,不出事无所谓,出了事就是麻烦。"一名从事外卖送 餐工作多年的外卖员这样告诉红星新闻记者。 据新华社报道,自2008年中国第一笔线上外卖诞生,外卖行业快速崛起——骑手超1000万 名,日均配送超8000万单,相关联消费超万亿元。与万亿元市场相伴的,受平台算法和规则 的规制,外卖员电动车超标超速问题也始终受到关注。 日前红星新闻记者梳理发现,中国裁判文书网多起案例显示,因为驾驶超标电动车,外卖员在送餐过程 中一旦发生交通事故,往往会被交警部门将电动车认定为机动车,保险公司则会以"无证驾驶机动车"属 于免责条款为由拒赔,由此引发赔付困境。而为了获得赔偿,有外卖员会选择进行诉讼。 红星新闻记者以"外卖、机动车、保险、判决书"等为关键词在中国裁判文书网进行搜索,仅2025年搜索 结果就达450余起案件,其中有多起案件系因保险公司以外卖员无证驾驶电动车为由拒赔而引发诉讼。 虽然一般情况下会判决保险公司赔偿,但生效判决作出时间距事故发生时间已过去短则数月长则一年 多,无论对于外卖员本人还是事故其他受害者权益都会带来影响。 对于超标电动车出现事故后引发的保险赔付困境,有律师在接受红星新闻记 ...
从3399元跌至1866元,16GB+512GB+骁龙8Gen3,堪称“新卷王”
Xin Lang Cai Jing· 2025-06-22 18:23
现在买手机,真是一个比"拼夕夕"还拼的年代。大家都在卷配置、卷价格、卷快充、卷影像、卷你钱 包。你刚觉得自己买的手机不错,转头发现别家又把价格打了个对折,配置还往上加了两个Buff。这时 候,如果你不是天天泡论坛或者被迫关注数码新闻,真可能错过一些"深藏不露"的狠角色。这次的主 角,就是这么一个被"埋没"的宝藏真我GT6。 如果你不是那种"数字+手机型号都能倒背如流"的人,可能对真我这个品牌了解不多。没关系,简单粗 暴一点,它是OPPO的"性价比马甲",定位和Redmi、iQOO差不多,但比它们还要再便宜一点、猛一 点、甚至冷门一点。你问为啥冷门?因为营销费都花在真材实料上了,不像某些品牌,请代言人不眨 眼,但手机却眨个不停。 先说屏幕,不是那种"看起来亮"但用久了眼睛发酸的屏幕,也不是啥中低端OLED,它上的是定制京东 方S1+柔性电竞屏,6000nit亮度+8T LTPO技术,这意味着你在大太阳下看抖音都不费劲,打游戏还不 会出现"卡卡卡"的掉帧现象。再来个护眼功能,2160Hz高频PWM调光,晚上关灯刷短视频也不怕眼睛 干成葡萄干。 处理器当然是大魔王级别的骁龙8 Gen3,性能强到不讲道理。配上114 ...
周大福(1929.HK):产品结构优化 同店逐季改善
Ge Long Hui· 2025-06-22 18:19
机构:中邮证券 研究员:李鑫鑫 事件 公司发布25 年年报,25 财年公司实现营收896.56 亿港元,同比-17.5%,归母净利润59.16 亿港元,同 比-8.98%。25 财年起公司将黄金借贷由销售成本划为其他收益及亏损,不考虑黄金借贷因素,公司经 营利润147.46 亿港元,同比+9.8%。 公司发布25 年4-5 月未经审计经营数据,零售值同比-1.7%,中国内地-2.9%,港澳及其他市场+6.3%, 其中中国内地黄金首饰及产品同店销售+0.9%。 点评 市场分析:逐季改善。25 财年公司实现营收897 亿港元,同比-17.5%,其中中国内地销售额746 亿港 元,同比-17%,港澳及其他151亿港元,同比-21%。 1)内地:逐季改善,加盟优于直营。 25 财年底周大福珠宝在内地共有零售点6274 家,净减少896 家,同店销售同比-19.4%。其中: —逐季改善:内地、香港及澳门同店销售虽然继续处于下跌态势,但跌幅逐步收窄,如中国内地直营门 店同店FY2025 各个季度分别为-26%、-24%、-16%、-13%。 —加盟优于直营:中国内地直营门店同店销售额下滑19.4%,同店销量下滑30.1% ...
ROSEN, A HIGHLY RANKED LAW FIRM, Encourages Fortrea Holdings, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action – FTRE
GlobeNewswire News Room· 2025-06-22 18:16
Core Viewpoint - Rosen Law Firm is reminding investors who purchased Fortrea Holdings, Inc. securities during the specified Class Period of the upcoming lead plaintiff deadline on August 1, 2025, for a class action lawsuit [1][2]. Group 1: Class Action Details - Investors who bought Fortrea securities between July 3, 2023, and February 28, 2025, may be eligible for compensation without any out-of-pocket fees through a contingency fee arrangement [1]. - A class action lawsuit has already been filed, and interested parties must move the Court to serve as lead plaintiff by the August 1, 2025 deadline [2]. Group 2: Law Firm Credentials - Rosen Law Firm has a strong track record in securities class actions, having achieved the largest settlement against a Chinese company at the time and being ranked No. 1 for securities class action settlements in 2017 [3]. - The firm has recovered hundreds of millions of dollars for investors, including over $438 million in 2019 alone [3]. Group 3: Case Allegations - The lawsuit alleges that Fortrea made false and misleading statements regarding its revenue projections and cost savings, leading to inflated EBITDA targets for 2025 [4]. - It is claimed that the viability of Fortrea's post-Spin-Off business model and its financial prospects were overstated, resulting in material misstatements [4].
全国铁路7月1日实行新列车运行图:“旅游专线”串联景区 赏美景品民俗
Yang Shi Wang· 2025-06-22 18:12
国铁西安局西安站客运员 苏楷淇:过去要是想从西安去这些热门旅游城市,那往往得多次换乘。但现在新增的G3763次列车,8:02从西安北站出发, 15:35就能到达武隆南站,全程仅需七个半小时。不仅能一站直达,还大大节省了时间。 高铁向着景区开,从中原城市到海边也有了新选择,许昌到日照,安阳到三亚也都有了高铁通行。渝厦高速铁路重庆至黔江段将于7月1日正式开通运 营,届时张家界西站开行动车组将达108趟。 针对暑期出游增开消夏列车 一日游多地 央视网消息:今年7月1日全国铁路调图后,全国铁路将新增客运列车236列。这几天,新增列车的运行方向也陆续发布,本次调图后,有更多的高铁线 路选择沿热门旅游景区开行,为暑期出行的旅客提供一条条旅游新通道。 "旅游专线"串联景区 赏美景品民俗 连接黄河与长江,铁路西安北站至长沙站计划增开G3763和G3764次高速动车组1对。以往,从西安到长沙的高铁大多先向东到郑州,再向南经武汉抵达 长沙。而此次新增开的G3763次高速动车组则走出了一条截然不同的路线。它途经汉中、成都、重庆等地,经停武隆南、张家界西、常德等站点,将秦岭风 光、巴蜀文化、武陵源景色等丰富的旅游资源一线串联,堪称" ...
美国参众两院分别发起决议 拟限制总统发起战争的权力
财联社· 2025-06-22 18:12
美总统特朗普美东时间21日宣布,美军"成功打击"伊朗福尔多、纳坦兹和伊斯法罕三处核设施。 此外,弗吉尼亚州民主党参议员蒂姆·凯恩22日在接受美国福克斯新闻网的采访时表示,参议院少数党 领袖查克·舒默正在推动尽快就一项限制总统战争权力的决议进行投票,以便参议院所有议员都必须宣 布美国是否应该与伊朗开战。据报道,预计参议员将于24日听取有关伊朗局势的简报。 (本文来源:央视 新闻) 当地时间6月22日,美国共和党众议员托马斯·马西(Thomas Massie)和民主党众议员罗·卡纳(Ro Khanna)共同发起了一项战争权力决议,旨在控制行政部门并重申国会的权威。马西表示,美国没有 面临迫在眉睫的威胁,发生这一切的时候国会正在休假,议员们没有得到简报。 ...
美国参众两院分别发起决议 拟限制总统发起战争的权力
news flash· 2025-06-22 18:10
据央视新闻,当地时间6月22日,美国共和党众议员托马斯·马西(Thomas Massie)和民主党众议员罗· 卡纳(Ro Khanna)共同发起了一项战争权力决议,旨在控制行政部门并重申国会的权威。马西表示, 美国没有面临迫在眉睫的威胁,发生这一切的时候国会正在休假,议员们没有得到简报。此外,弗吉尼 亚州民主党参议员蒂姆·凯恩22日在接受美国福克斯新闻网的采访时表示,参议院少数党领袖查克·舒默 正在推动尽快就一项限制总统战争权力的决议进行投票,以便参议院所有议员都必须宣布美国是否应该 与伊朗开战。据报道,预计参议员将于24日听取有关伊朗局势的简报。 ...
基金营销“信任危机”形成已久 投顾转型点出破题关键
Zheng Quan Shi Bao· 2025-06-22 18:03
Core Viewpoint - The China Securities Regulatory Commission (CSRC) has issued a plan to promote the high-quality development of public funds, emphasizing the need for a classification evaluation mechanism for fund sales institutions to address the current "scale-first" mentality and the "trust crisis" in fund marketing [1][2]. Group 1: Evaluation Mechanism - The plan requires the establishment of a classification evaluation mechanism for fund sales institutions, incorporating metrics such as the scale and proportion of equity fund holdings, the scale and proportion of newly launched products, investor profit and loss, and the scale of regular investment [2][3]. - Institutions with higher evaluation results will receive priority in product access, license applications, and innovative business opportunities, encouraging a shift from a sales-driven model to one focused on customer service and experience [2][3]. Group 2: Industry Transformation - The release of the plan has accelerated changes in the fund distribution landscape, with several fund companies announcing the termination of sales partnerships with certain institutions, indicating a shift towards more sustainable business models [4][5]. - The exit of smaller fund sales institutions signals a natural clearing mechanism that will optimize the industry ecosystem and lead to a healthier market structure [5][6]. Group 3: Investor-Centric Approach - The plan encourages a transition from a focus on sales volume to long-term value, emphasizing the importance of investor retention and returns rather than merely transaction volume [3][6]. - The investment advisory model, which prioritizes investor interests, is seen as a key solution to the challenges faced in the fund distribution sector, requiring a deeper understanding of client needs and goals [7][8]. Group 4: Fee Reduction Impact - The plan also calls for a reasonable reduction in subscription and sales service fees for public funds, which may pose short-term challenges for sales institutions but will ultimately drive them towards a buyer-centric transformation [9][11]. - The trend of fee reduction is expected to promote the development of wealth management and advisory services, as institutions adapt to a more competitive environment [11][12].