Core Insights - Novo Nordisk's investigational drug Mim8 shows promising results in the phase 3b FRONTIER5 trial, allowing a direct switch from emicizumab without a washout period, demonstrating good tolerability and no safety concerns in patients with haemophilia A [1][3][5] - The patient-reported outcomes indicate a strong preference for the Mim8 pen-injector over the previous emicizumab injection system, with high satisfaction regarding its ease of use [4][5] Group 1: Trial Results - The FRONTIER5 trial involved 61 adults and adolescents with haemophilia A, showing that switching to Mim8 was well-tolerated with no reported thromboembolic events or treatment-emergent adverse events leading to discontinuation [3][5] - A sustained increase in thrombin peak levels was observed after switching to Mim8, without an exaggerated thrombin response, indicating effective management of bleeding risk [2][6] Group 2: Patient-Reported Outcomes - 97% of patients expressed a "very strong" or "fairly strong" preference for the Mim8 pen-injector compared to emicizumab, highlighting significant user satisfaction [4] - 98% of participants found the Mim8 pen-injector "very easy" or "easy" to use, and 100% felt confident in using it correctly, suggesting a positive reception of the new delivery method [4][5] Group 3: Future Prospects - Novo Nordisk plans to submit Mim8 for regulatory review in 2025, with ongoing data from the FRONTIER programme to be shared at future congresses and publications [5][10] - The results from the FRONTIER5 trial contribute to the overall safety profile of Mim8, reinforcing its potential as a future treatment option for haemophilia A [5][6]

当地时间6月22日， 法国总统马克龙在爱丽舍宫主持召开国防与国家安全会议。马克龙表示，仅靠严厉 的军事打击报复无法实现伊以停火。他指出，"我们明确呼吁各方保持克制，因为我们坚信，严厉的军 事打击报复无法带来我们期望的结果。" ...

当地时间22日，叙利亚首都大马士革东部一座教堂当天发生爆炸。据当地媒体报道，爆炸已造成25人丧 生，数十人受伤。叙利亚国家通讯社的报道将事件定性为"恐怖袭击"，报道显示已有大量伤者被运送至 医院，安全部门也已在相关地区加派人手。 ...

当地时间6月22日，一位白宫高级官员表示，美国总统特朗普21日下达了袭击伊朗核设施的最终命令， 并指示国防部长赫格塞思继续推进袭击行动。美国副总统万斯6月22日在接受美国国家广播公司采访时 也称，特朗普在炸弹投下前几分钟做出了决定。 ...

Core Viewpoint - The U.S. State Department has issued a warning for American citizens in Iran to prepare for long-term sheltering in place, indicating that the U.S. government is not expected to provide direct assistance for departure [1] Group 1 - The U.S. government has no diplomatic presence in Iran, complicating the situation for American citizens seeking assistance [1] - Switzerland, which has been responsible for assisting U.S. citizens in Iran, has closed its embassy in Tehran, further limiting options for Americans [1] - American citizens are advised to utilize existing means to leave Iran, as direct government assistance is not anticipated [1]

俄罗斯国防部22日通报称，俄军使用"伊斯坎德尔-M"弹道导弹对赫尔松州达维多夫布罗德地区的乌军 训练场进行了打击。此次打击摧毁了10余辆军用车辆以及配备无人机拦截装置的防空作战小组。乌军人 员损失超过70人。 ...

智通财经6月23日电，据央视新闻，俄罗斯国防部22日通报称，俄军使用"伊斯坎德尔-M"弹道导弹对赫 尔松州达维多夫布罗德地区的乌军训练场进行了打击。此次打击摧毁了10余辆军用车辆以及配备无人机 拦截装置的防空作战小组。乌军人员损失超过70人。22日稍早时，乌克兰武装部队地面部队通报称，当 天俄罗斯军队对乌克兰陆军某机械化旅训练场发射导弹，造成3人死亡，11人受伤。通报中称，由于在 接到空袭警报后及时采取了安全措施，避免了大量人员伤亡，乌克兰武装部队陆军司令部已成立特别委 员会，负责详细调查事件的所有情况。执法机构也正在现场开展工作。 俄称使用"伊斯坎德尔-M"导弹打击乌军一训练场 ...

商品货币对中，澳元兑美元跌超0.23%，纽元兑美元跌0.33%，美元兑加元涨0.08%。 美元兑瑞郎上扬至0.8277，随后回落至0.8186较上周五最终报价大致持平。 欧元兑美元跌0.48%，报1.1466，英镑兑美元跌0.25%，报1.3414。 美元兑G10货币报价在周一（6月23日）澳大利亚悉尼早间交易中多数走高。 美元兑日元上扬至146.22日元，随后回落至持平暂报146.09日元。 ...

Group 1: Market Performance and Investor Sentiment - Quantum computing stocks experienced significant growth in 2024, with companies like Quantum Computing and Rigetti Computing surging over 1,000% [1] - The optimism surrounding quantum stocks is driven by revenue growth and scientific advancements, suggesting potential for further gains in the second half of the year [1][9] - Recent progress in trade talks and corporate earnings indicate sustained spending on technology, enhancing investor confidence in quantum companies [8][13] Group 2: Technology and Development - Quantum computing utilizes qubits for data storage, allowing for exponential scaling and solving complex problems much faster than classical computers [4] - Current quantum companies are in the early stages of development, with truly useful quantum computers still several years away, providing ample room for revenue growth [5] - D-Wave Quantum has launched its Advantage2 quantum computer, which has been tested with over 20 million customer problems, indicating its readiness for applications in materials simulation and AI [10] Group 3: Company-Specific Insights - Rigetti and IonQ are highlighted as companies that have not fully recovered from earlier declines, with year-to-date decreases of 25% and 5% respectively, but potential revenue growth could positively impact their share performance [9] - D-Wave Quantum reported a remarkable 500% increase in revenue last quarter, reaching a record $15 million, which could further boost its stock performance [11] - The economic environment will play a crucial role in determining the near-term direction of quantum companies, as a strong economy encourages customer spending on their products and services [12]

Group 1 - Tesla has launched its robotaxi service, featuring fully autonomous Tesla Model Y vehicles, with initial rides offered to a select group of users [2][3] - The first rides are priced at a flat fee of $4.20, and the service was initially delayed due to the release of the official Tesla robotaxi app [3][4] - Tesla's AI division stated that the robotaxis are designed for scalability and do not require expensive equipment or extensive mapping [4] Group 2 - A dedicated website has been launched for users to sign up for early access to the robotaxi service in their areas, along with an X feed focused on Tesla robotaxis [5] - The launch of Tesla robotaxis positions Austin as a competitive hub in the race for driverless transportation, alongside other companies like Waymo and Zoox [5][6] - Other companies in the autonomous vehicle space include Waymo, which launched a ride-hailing service, and Zoox, which opened a robotaxi production facility in Austin [6]