美国银行称，美国股票基金迎来2025年以来最大单周流入，吸引了370亿美元资金，同时投资者也增持 了全球股票、债券、黄金和加密货币基金。美国银行上周五（6月20日）发布的报告援引EPFR Global的 数据称，截至6月18日当周，投资者向股票基金配置了454亿美元，为10周以来的最大流入量；向债券基 金配置了超过180亿美元；向黄金基金配置了28亿美元，为8周以来的最大流入量；向加密货币基金配置 了17亿美元；而货币市场则有117亿美元流出。 ...

Core Insights - Molecular Partners AG and Orano Med have announced the launch of MP0726, a Radio-DARPin candidate targeting mesothelin (MSLN), with preclinical data to be presented at the 2025 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging [1][2] Group 1: Product Development - MP0726 demonstrates high affinity and selectivity for the membrane-proximal domain of MSLN, showing a tumor accumulation of up to 34% and a tumor to kidney ratio of up to 4.5 in vivo [2][3] - The candidate is designed to target ovarian cancer, leveraging the unique properties of DARPins to selectively bind to MSLN, which is highly expressed in tumors but lower in healthy tissues [3][8] - MP0726 is the second Radio-DARPin program to enter preclinical development, following MP0712, which targets DLL3 and is set to begin dosing in a Phase 1 study in the US in the second half of 2025 [6] Group 2: Strategic Collaboration - The collaboration between Molecular Partners and Orano Med has shown significant progress, highlighting the effectiveness of their joint R&D efforts in developing differentiated clinical candidates [4][5] - Orano Med's capabilities in R&D and manufacturing, along with a virtually unlimited supply of the starting isotope, position it uniquely to support the development of these new therapies [4] Group 3: Company Background - Molecular Partners AG is a clinical-stage biotech company focused on developing DARPin therapeutics, with oncology as its main area of focus [9] - Orano Med specializes in targeted alpha-particle therapies using lead-212 (Pb), with its most advanced asset, AlphaMedix, having received Breakthrough Designation from the FDA in 2024 [10]

伊朗外长抵达莫斯科 将与普京会面 智通财经6月23日电，据央视新闻，当地时间22日晚间，伊朗外交部长阿拉格齐抵达俄罗斯首都莫斯 科。阿拉格齐此行将就美国和以色列对伊朗发动袭击后的地区及国际局势发展同俄罗斯总统普京及其他 俄方高级官员进行磋商。 ...

Core Viewpoint - Apple is reportedly considering the acquisition of AI startup Perplexity AI to enhance its AI technology and expertise, particularly in the context of potentially losing its long-standing search deal with Google [2][3]. Group 1: Acquisition Talks - Apple has held in-house discussions regarding the acquisition of Perplexity AI, with key figures such as Adrian Perica and Eddy Cue involved in the talks [2]. - The discussions are in early stages and may not lead to a formal offer [2][4]. Group 2: Strategic Implications - Acquiring Perplexity AI could enable Apple to develop an AI-based search engine, which is crucial as it faces the risk of losing its default search arrangement with Google [3]. - Perplexity AI currently processes 780 million queries monthly, with a growth rate exceeding 20% month over month [3]. Group 3: Competitive Landscape - Apple's approach to AI has been described as "restrained" compared to competitors like Amazon, Google, and Microsoft, which are aggressively pursuing large language models and enterprise-scale AI solutions [5]. - The company risks falling behind in the broader AI economy, as most enterprise AI innovation is occurring in the cloud, which Apple has not fully embraced [6][7].

上周，A股板块密集轮动。除 银行板块持续走强外，其他板块均呈现震荡走势，前期领涨的科技股有所 退潮。在机构看来，短期海外扰动因素明显增加，构成压制A股风险偏好的因素。但展望下半年，随着 一系列资本市场改革措施的逐步推进，2025年整体市场活跃度有望提升。在政策催化下，具备产业趋势 支撑、半年报业绩表现较佳的科技板块值得关注。 (上证报) ...

中信证券报告认为，原油是受中东局势影响最为直接的大宗商品。从供给来看，中东紧张局势一旦直接 牵涉到产油国，相关国家的石油供给往往要在冲突烈度显著下降或战事彻底平息后才能恢复。从价格来 看，紧张局势推动下的油价上行往往发生在开战初期，后续油价中枢仍由供需基本面决定。拉长时间来 看，随着中东产油国供给份额下降以及消费国石油储备、应急机制趋于完善，中东紧张局势对全球油价 的影响在边际弱化。 ...

另一方面，优赛道，在建设现代化产业体系上勇担当。会议要求，要注重规划引领，系统衔接国家重点 产业发展战略，科学制定国资国企"十五五"规划，基于企业自身战略定位和产业优势，强化整体统筹布 局，选准战新产业（300832）培育的"主攻方向"，坚决避免"内卷式"竞争和盲目多元化。要加大增量投 入力度，围绕新产业新赛道，聚焦科技属性和技术价值，规范发展天使投资、风险投资、股权投资，引 导国企基金"投早投小投硬"。要加大力度推动传统产业高端化智能化绿色化转型升级。 记者日前从国务院国资委获悉，截至2025年一季度末，各中央企业、各地国有企业改革深化提升行动重 点改革任务平均完成率已超过80%。 高质量完成国有企业改革深化提升行动是今年国企改革工作的重点。目前，距离深化提升行动收官只剩 半年时间，接下来改革重点有哪些？工作怎么抓？国务院国资委日前召开国有企业改革深化提升行动 2025年第二次专题推进会，为下阶段工作划定重点。 国务院国资委党委委员、副主任李镇在会上表示，总体上看，深化提升行动实施以来，广大国有企业在 深化体制机制改革、推动科技创新和产业创新融合方面主动作为，科技创新成果亮点纷呈，战略性新兴 产业和未来产业 ...

Core Insights - Tesla's robotaxi service is set to launch in Austin, Texas, with rides priced at $4.20, as announced by CEO Elon Musk [1] - The launch comes amid new legislation in Texas requiring permits for operating self-driving vehicles, indicating a shift towards more regulation in the state [3][9] Regulatory Environment - Texas Governor Greg Abbott signed a law requiring a state permit for self-driving vehicles, which will take effect on September 1 [4][9] - The law allows state authorities to revoke permits if a driverless vehicle is deemed to endanger the public and mandates firms to provide emergency response information [9][10] - The new legislation contrasts with a 2017 law that prohibited cities from regulating self-driving cars, showing a more cautious approach from state officials [5] Tesla's Robotaxi Launch - Tesla plans to have front-seat riders as "safety monitors," although their level of control over the vehicles remains unclear [2] - The initial trial will involve 10 to 20 Model Y vehicles operating in a limited area of Austin, targeting a select group of Tesla online influencers [5] - The company aims to avoid operating in bad weather and difficult intersections, and will not carry passengers under 18 [14] Market Context - Tesla's stock value heavily relies on its ability to deliver robotaxis and humanoid robots, making the success of this launch critical [13] - The company is adopting a unique approach by relying solely on cameras for navigation, unlike competitors that use lidar and radar systems [17] - The commercial rollout of autonomous vehicles has been fraught with risks, as evidenced by incidents involving competitors like GM's Cruise [16]

"瘦身经济"正在升温 6月以来北京地区主打"健康""低脂"的轻食套餐团购订单量同比增长356% 智通财经6月23日电，我国"体重管理年"行动持续推进，在国家政策引导与大众健康意识提升的双重驱 动下，"瘦身经济"正在升温。某平台数据显示，今年6月以来，"健身月卡 次卡"搜索量同比增长 31.6%，"24小时自助健身房次卡"搜索量同比增长96.9%。从消费趋势来看，人们对趣味性运动的需求 正在攀升。6月以来，"室内蹦床运动馆"的搜索量同比增长96.4%，"壁球馆"搜索量同比增长188%。6月 以来，北京地区"轻食餐厅"关键词搜索量同比增长145%，主打"健康""低脂"的轻食套餐团购订单量同比 增长356%，其中，酸奶牛油果、蔬果茶、鲜虾能量碗均是消费热门。 (央视财经) ...

Core Insights - Novo Nordisk's investigational drug Mim8 shows promising results in the phase 3b FRONTIER5 trial, allowing a direct switch from emicizumab without a washout period, demonstrating good tolerability and no safety concerns in patients with haemophilia A [1][3][5] - The patient-reported outcomes indicate a strong preference for the Mim8 pen-injector over the previous emicizumab injection system, with high satisfaction regarding its ease of use [4][5] Group 1: Trial Results - The FRONTIER5 trial involved 61 adults and adolescents with haemophilia A, showing that switching to Mim8 was well-tolerated with no reported thromboembolic events or treatment-emergent adverse events leading to discontinuation [3][5] - A sustained increase in thrombin peak levels was observed after switching to Mim8, without an exaggerated thrombin response, indicating effective management of bleeding risk [2][6] Group 2: Patient-Reported Outcomes - 97% of patients expressed a "very strong" or "fairly strong" preference for the Mim8 pen-injector compared to emicizumab, highlighting significant user satisfaction [4] - 98% of participants found the Mim8 pen-injector "very easy" or "easy" to use, and 100% felt confident in using it correctly, suggesting a positive reception of the new delivery method [4][5] Group 3: Future Prospects - Novo Nordisk plans to submit Mim8 for regulatory review in 2025, with ongoing data from the FRONTIER programme to be shared at future congresses and publications [5][10] - The results from the FRONTIER5 trial contribute to the overall safety profile of Mim8, reinforcing its potential as a future treatment option for haemophilia A [5][6]