Financial Data and Key Metrics Changes - In 2025, the company booked record orders totaling more than $1 billion, representing a 26% increase compared to 2024 [4][8] - Full year revenue totaled $925.4 million, up 7.5% versus 2024, with more than half of the growth being organic [22] - Adjusted EBITDA for the full year was $227.9 million, up 12% compared to 2024, with margins expanding by 90 basis points [22][26] - Adjusted EPS was $0.46, a 12% increase despite an approximately 50 million share increase in 2025 [23] Business Line Data and Key Metrics Changes - Nuclear power organic revenue grew more than 11% in 2025, while nuclear medicine organic revenue grew more than 13% [4] - The medical segment revenue declined 3.5% in Q4 2025, with full year medical segment revenue growing 3.7% [27] - Adjusted nuclear power orders grew 52% in 2025, supported by all three verticals: new utility-scale reactors, the installed base, and SMRs [20] Market Data and Key Metrics Changes - The nuclear power end market demonstrated the strongest growth, supported by $150 million from the large opportunity pipeline [8] - The defense and diversified end market saw a doubling of orders in Q4, primarily in the U.S. and with NATO [21] - The medical segment faced headwinds due to tough comps from the prior year, with nuclear medicine orders down only 6% in 2025 [9] Company Strategy and Development Direction - The company articulated a strategic priority to increase nuclear power exposure, acquiring Certrec and Paragon Energy Solutions to augment its North American nuclear power presence [5][11] - The company expects to leverage its strong international presence to take the capabilities of the acquired companies global [11] - The focus on AI and digital strategies is expected to enhance productivity and customer-facing applications, with significant investments being made in this area [61][66] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the nuclear power sector, citing a robust demand for solutions due to the aging installed base and modernization needs [6][7] - The company anticipates double-digit organic growth in nuclear power and nuclear medicine for 2026, supported by favorable macro conditions [4][15] - Management noted that the headwinds faced in 2025 were seen as demand deferrals rather than a secular change in the market [10] Other Important Information - Adjusted free cash flow totaled $131 million in 2025, approximately double 2024's performance, reflecting improved earnings and reduced net interest expense [29] - The company expects 2026 total revenue to grow between 22%-24%, with organic revenue growth guidance of 5%-7% [15][16] Q&A Session Summary Question: Can the large opportunity pipeline translate to double-digit growth in backlog for 2026? - Management noted that while large project timing is complex, they feel good about the dynamics driving growth in the nuclear power vertical [36][38] Question: What is the expectation for medical growth in 2026? - Management indicated that they expect a quick recovery in medical, particularly in Europe and China, and are optimistic about mid-single-digit growth [39][40] Question: How does the Paragon acquisition impact growth expectations? - Management highlighted that Paragon's strong customer intimacy and market coverage are expected to drive significant growth, with a projected 25% growth for Paragon in 2026 [68][70] Question: What is the expected contribution from large orders booked in 2025? - Management clarified that while there will be some contribution, the first year of larger contracts tends to be the lightest [78] Question: How material are SMRs to the growth story? - Management acknowledged that while SMRs are currently a small percentage of total revenue, they see significant growth potential and are actively engaging with key players in the market [81]

Summary of Jade Biosciences Conference Call Company Overview - **Company**: Jade Biosciences (NasdaqCM:JBIO) - **Founded**: June 2024 - **Management Team**: Includes experienced members from Chinook Therapeutics, focusing on iGAN (IgA nephropathy) and autoimmune diseases - **Assets**: Three key assets acquired from Paragon, a protein engineering company Industry and Market Insights - **Lead Program**: Anti-APRIL for IgA nephropathy, a significant unmet medical need with a market opportunity exceeding $10 billion in the US alone [2] - **Clinical Development**: Initiated a Phase I study in August 2025, with results expected in the first half of 2026, aiming for rapid transition to patient studies [2][3] Key Programs and Developments - **JADE201**: A eufucosylated antibody targeting BAFF-R, expected to enter clinical trials in the first half of 2026 [2][3] - **Third Program**: Details not disclosed, anticipated to enter trials in the first half of 2027 [3] - **Financial Position**: Strong resources to fund trials through the first half of 2028 [3] Clinical Data and Efficacy - **ASN Conference Insights**: - iGAN is emerging as a large prospective market with promising data from competitors like Vera and Vertex [5][6] - Vertex reported a 64% reduction in proteinuria in Phase II studies, while Vera showed a 42% placebo-adjusted reduction [6] - Sibeprenlimab data indicated a 54% decrease in proteinuria over 12 months, highlighting the importance of APRIL inhibition [7][8] Mechanism of Action and Therapeutic Window - **APRIL vs. BAFF**: - Evidence suggests that APRIL inhibition alone provides significant disease-modifying benefits in iGAN without the need for BAFF [10][11] - Adding BAFF does not enhance clinical outcomes, indicating that iGAN is primarily driven by APRIL-responsive plasma cells [10][11] Regulatory Landscape - **FDA Considerations**: - The FDA is exploring new study designs to support innovation in iGAN, potentially shortening confirmatory study durations from two years to one year [30][31] - This shift is seen as beneficial for anti-APRIL therapies, which show early and significant eGFR improvements [30][31] Future Directions and Lifecycle Management - **Exploration of New Indications**: - Plans to investigate other autoimmune diseases, including IgM-mediated diseases and Sjogren's syndrome, based on the success of current programs [24][34] - JADE201's development will focus on generating safety and tolerability data in RA patients before expanding to other indications [34] Conclusion - Jade Biosciences is positioned to capitalize on significant market opportunities in the autoimmune disease space, particularly with its lead program targeting iGAN. The company is leveraging strong clinical data and a robust financial position to advance its pipeline and explore new therapeutic avenues.

Summary of Jade Biosciences (JBIO) FY Conference Call - July 14, 2025 Company Overview - **Company**: Jade Biosciences (JBIO) - **Focus**: Development of therapies for autoimmune diseases, specifically targeting IgA nephropathy with lead candidate JAD 101 [1][2] Pipeline and Product Development - **Lead Candidate**: JAD 101, aimed at treating IgA nephropathy, currently in preclinical stage with plans to enter clinical trials in 2025 [6][34] - **Additional Assets**: - JAD 102: Broader B cell depleting target, expected to enter the clinic in the first half of 2026 [7] - JAD 103: More advanced asset with clinical validation anticipated to enter the clinic in 2027 [8] Market Opportunity - **Market Size**: Over $10 billion branded opportunity in the IgA nephropathy space, with 170,000 patients in the US, 60-70% of whom require further treatment [11][12] - **Current Treatments**: Existing medications do not modify the disease or preserve kidney function, indicating a significant demand for new therapies [12] Competitive Advantage of JAD 101 - **Mechanism of Action**: JAD 101 is a fully human monoclonal antibody that neutralizes APRIL, designed to avoid large immune complex formation, which is a limitation of first-generation anti-APRIL antibodies [20][22] - **Pharmacokinetics**: JAD 101 has a half-life of 27 days, significantly longer than competitors, allowing for less frequent dosing (every eight weeks) [19][22] - **Clinical Differentiation**: Expected to provide superior efficacy with a focus on minimizing immune modulation, which is preferred by nephrologists [15][16] Clinical Trial Design - **Phase 1 Study**: Conventional single ascending dose study in healthy volunteers to assess safety, tolerability, pharmacokinetics, and immunogenicity, with interim data expected in the first half of 2026 [24][25] - **Biomarker Tracking**: Focus on measuring free APRIL reductions and downstream immunoglobulin changes to define dosing and frequency for future clinical development [25][27] Global Strategy - **Market Expansion**: Significant focus on the Asia-Pacific region due to a higher prevalence of IgA nephropathy, with plans to efficiently access these markets [30][34] Intellectual Property - **IP Landscape**: JAD 101 is a de novo antibody with IP filed, expected to have protection extending into the mid-2040s [32] Financial Position and Future Catalysts - **Cash Position**: $50 million in cash post-reverse merger, with an additional $205 million from a PIPE financing, providing funding through 2027 [36] - **Upcoming Catalysts**: - Initiation of clinical trials for JAD 101 by the end of 2025 - Phase 1 readout in the first half of 2026 - Entry into the clinic with JAD 102 in the first half of 2026 [34][36]