Group 1 - The research team has developed a detailed "molecular battle map" of human immune cells responding to transplanted pig kidney tissues, marking a significant breakthrough in overcoming xenotransplantation immune rejection issues [1][2] - The study reveals that signs of antibody-mediated rejection can be detected as early as day 10 post-transplant, peaking at day 33, confirming the understanding that rejection reactions are aggressive yet progress slowly [1] - A dynamic tracking period of 61 days allowed the identification of a critical "treatment time window," and targeted therapeutic interventions have shown significant effects in suppressing immune attacks [1][2] Group 2 - By understanding specific immune interactions at the molecular level, the research enables the formulation of precise anti-rejection strategies, potentially increasing transplant survival rates [2] - The findings provide a roadmap for optimizing genetically edited pigs and developing new anti-rejection drugs, with genetically modified pig kidneys expected to enter clinical routine applications within ten years, pending regulatory approval [2] - The research identifies key intervention time windows, laying a solid foundation for developing more effective anti-rejection therapies and guiding future research directions [2]

Company Overview - Xiamen Aide Biological Technology Co., Ltd. specializes in tumor gene testing reagents, software, and supporting instruments, as well as providing testing services and drug clinical research services [1] - The main products include testing reagents, testing services, and drug clinical research services [1] Financial Performance - For Q1 2025, the company reported revenue of 272 million yuan, a year-on-year increase of 16.63% [1] - The net profit for the same period was 90.47 million yuan, reflecting a year-on-year growth of 40.92% [1] - The sales gross margin stood at 83.48% [1] Market Position - As of July 2, the company's stock closed at 21.28 yuan, down 1.48%, with a rolling PE ratio of 29.64 times [1] - The total market capitalization is 8.332 billion yuan [1] - In comparison to the medical device industry, which has an average PE ratio of 51.29 times and a median of 37.02 times, Aide Biological ranks 67th [1][2] Capital Flow - On July 2, the net outflow of main funds for Aide Biological was 11.87 million yuan, with a total outflow of 19.57 million yuan over the past five days [1]

临床医学 、 生命科学、 生物学、生物医学工程、药学等相关专业。 复旦大学宋振举教授课题组招聘博士后 宋振举教授简介 宋振举 ， 复 旦大学附属中山医院急诊科主任医师、博士研究生导师，复旦大学附属中山医院副院长，复 旦大学附属金山医院院长，上海市急危重症临床研究中心主任，国家重点研发计划首席科学家，上海市肺 部炎症与损伤重点实验室副主任 , 上海市重大传染病和生物安全研究院双聘PI ， 国家临床重点专科负责人 。中华医学会急诊医学分会第九届青年委员会副主任委员，中华医学会急诊医学分会危重病学副组长，中 国医药教育协会急诊医学专科分会副主任委员 , 中国医学救援协会生命支持技术分会第一届理事会副会长 。 《中国临床医学》 和《元宇宙医学》杂志副主编， 《中华急诊医学杂志》通讯编委、《 World Journal of Emergency Medicine 》 编委。近 5年主持国家级课题5项，省部级课题3项；通讯作者在Nature Immunology, National Science Review, Nature Communications等国际知名期刊发表论文18篇，发表专 家共识5项，申请专利27项， ...

Core Viewpoint - The "I Seek Relatives for Martyrs" project, initiated by Sun Jiayi, aims to honor the martyrs of the Anti-Japanese War and World Anti-Fascist War by reconnecting them with their families, emphasizing the importance of passing on the spirit of heroism to the younger generation [1][2]. Group 1: Project Overview - The project has been active for 8 years, gathering over 40,000 martyr records and successfully reuniting more than 1,000 martyrs with their families [1]. - Sun Jiayi and her team have traveled across multiple countries and 25 provinces in China to locate the families of martyrs [1]. Group 2: Educational Initiatives - Sun Jiayi has engaged with over 60 schools nationwide, sharing stories of heroes and the significance of the project with students [2]. - The project has evolved to include educational activities that promote the legacy of martyrs among youth, fostering a sense of patriotism and responsibility [2][4]. Group 3: Youth Involvement - The involvement of young people is seen as crucial for the project's sustainability, with initiatives designed to create emotional connections between youth and martyrs [2][4]. - Activities such as visiting martyr families and participating in memorial services have allowed children to engage deeply with the project, enhancing their understanding of heroism [4][5]. Group 4: Future Plans - Sun Jiayi plans to lead children to visit the hometowns of martyrs and engage in activities that deepen their understanding of national pride and history [6]. - There is a focus on addressing the needs of rural and border area children for red education, aiming to cultivate youth who can share these stories widely [6].

Core Viewpoint - The celebration of the 104th anniversary of the founding of the Communist Party of China is marked by various activities across the country, emphasizing the importance of collective strength in advancing Chinese-style modernization [1] Group 1: Activities and Events - New party members took part in oath-taking ceremonies, reinforcing their commitment to their youthful mission [2] - In various historical sites, including the Yan'an Revolutionary Memorial and the Northeast Martyrs Memorial, party members revisited revolutionary sites to honor martyrs and pass on the red gene [4][6] - In Xiaogan, Hubei Province, the local government utilized historical sites to deepen party education and recall the struggles of revolutionary predecessors [9] Group 2: Educational Initiatives - Xiaochang County introduced an "immersive red and clean classroom" to bring revolutionary artifacts to life, allowing participants to deeply understand the resonance between red genes and integrity [12] - In Jinan, a themed party class was held to commemorate the 80th anniversary of the victory in the Anti-Japanese War, featuring descendants of war heroes [15] Group 3: Community Engagement - In the Jiaodong revolutionary area, local communities engaged in activities to remember the sacrifices made during the revolutionary struggle, fostering a spirit of perseverance [17] - On June 30, Hainan Province held a themed party day to honor outstanding individuals and groups in the construction of the Hainan Free Trade Port, showcasing the achievements of this initiative [19]

Group 1 - The "Glorious in the Party for 50 Years" commemorative medals were awarded to several veteran party members in celebration of the 104th anniversary of the founding of the Communist Party of China [1][2] - The event included a learning session on Xi Jinping's important article regarding the implementation of the Central Eight Regulations and a viewing of the documentary "Eight Regulations Change China" [1] - The city’s Political Consultative Conference emphasized the importance of remembering the party's glorious history and passing on the red gene, encouraging all party members to uphold their political integrity and spirit of struggle [1] Group 2 - The awarding ceremony was attended by notable figures including the Vice Chairman of the Political Consultative Conference and former leaders, highlighting the significance of the event [1] - Young party members expressed their intention to learn from the veteran members and continue the legacy of the party, showcasing intergenerational dialogue [2] - The event concluded with the viewing of the "Role Models 9" program and a warning education film, reinforcing the values and traditions of the party [2]

美诺华 20250701 这些特点使得 G389 不仅具有降糖减脂等功效，还能保证安全性和稳定性。 美诺华与美国密歇根大学合作开发的 G389 项目有哪些创新点和优势？ 美诺华与美国密歇根大学合作开发的 G389 项目是一种基于益生菌的非药领域 商业化产品。该项目利用常见益生菌作为底层细胞，通过基因编辑手段使其表 达 GLP-1 类似物。其主要创新点包括： 美诺华对 G389 的市场潜力持谨慎乐观态度，目标是覆盖 GLP-1 药物使 用后反弹人群的 10%，并探索更广泛的减肥或体重控制市场，重点仍放 在技术和注册上。 美诺华的核心竞争壁垒在于 G389 的专利保护和技术设计，使其在表达 量方面具有优势，且表达足量有效的 GLP-1 类似物难度较高，竞争对手 难以轻易进入。 1. 底层细胞逻辑：采用常见且无害的益生菌，如乳酸菌，具有保健功效， 并通过基因编辑实现高效表达 GLP-1 类似物。 2. 外分泌系统：这种益生菌能够在体内不断分泌 GLP-1 类似物，而不是像 传统工程菌那样需要破碎、分离和纯化。这使得它可以作为口服产品， 在肠道中持续释放有效成分。 摘要 美诺华创新性地利用基因编辑益生菌（如乳酸菌）高 ...

Group 1 - The article highlights the importance of honoring and supporting elderly party members, emphasizing their contributions and the need to learn from their dedication and spirit of hard work [1][2] - The city leaders, including An Wei, express admiration for the life stories and values of veteran party members, recognizing them as valuable assets to the party and the nation [2] - There is a call to continue promoting the spirit of the party and to implement educational initiatives that align with the central government's directives, focusing on maintaining a clean political environment [2] Group 2 - The article mentions specific elderly party members, such as 92-year-old Yang Genshen and centenarian Liu Qingru, who exemplify the values of dedication and commitment to the party [1][2] - An Wei emphasizes the need to pass on the "red gene" and continue the legacy of the party's founding principles, urging party members to strive for excellence in their work [2] - The article concludes with a note on the participation of other city leaders in the visit, indicating a collective effort to honor and support the elderly party members [3]

Core Viewpoint - The historical exhibition at the site of the Fifth National Congress of the Communist Party of China (CPC) aims to commemorate the significant events of 98 years ago, highlighting the challenges faced during the Chinese revolution and the maturation of the CPC [1][2][3] Group 1: Historical Context - The Fifth National Congress of the CPC was held in Wuhan, starting on April 27, 1927, at the National Wuchang First Primary School and later moving to the Hankou Huangpi Guild Hall [2] - The congress occurred during a critical period marked by the counter-revolutionary coup led by Chiang Kai-shek, representing a pivotal moment for the CPC as it transitioned from setbacks to a more mature organization [2][3] Group 2: Exhibition Details - The exhibition features a restoration of the historical venue, including a replica of the stage, banners, and seating arrangements, effectively reviving the revolutionary memories of that era [2] - The initiative to create the historical exhibition is aimed at preserving the red gene and consolidating the spirit of progress, utilizing valuable historical photographs and authoritative party literature [3] Group 3: Significance of the Exhibition - The core value of the exhibition lies in restoring the completeness of history, linking the opening ceremony in Wuchang with the main venue in Hankou, thus filling gaps in the narrative of party history and public understanding [3] - This restoration not only represents a geographical revival but also serves as a historical reminder of the CPC's exploration and strengthening of its own construction during a challenging period [3]

Core Insights - The self-sufficiency rate of vegetable seeds in China is approaching 91%, which significantly ensures the diversity of the "vegetable basket" [1] - A new domestic solid-phase gene chip for tomato breeding has been successfully developed and is expected to be commercially available by the end of this year [1] - The cost of gene testing is projected to decrease from 120 yuan per sample to 40 yuan, enhancing the efficiency of both upstream molecular breeding and downstream variety identification [1] Industry Developments - The launch of the first national tomato breeding autonomous solid-phase gene chip project commenced in May this year [1] - The application range of the newly developed gene chip will cover upstream tomato molecular breeding and variety selection, as well as downstream variety identification [1]