Core Insights - Septerna, Inc. announced a global collaboration with Novo Nordisk to develop oral small molecules for metabolic diseases, with potential milestone payments exceeding $2.2 billion [1][6] - The company is on track to select a next-generation oral small molecule PTH1R agonist for clinical advancement by the end of 2025 [1][5] - Septerna ended Q1 2025 with $398.2 million in cash, significantly extending its cash runway guidance to early 2028 due to the collaboration [1][11] Collaboration with Novo Nordisk - The partnership aims to discover, develop, and commercialize multiple oral small molecule medicines targeting obesity, type 2 diabetes, and other cardiometabolic diseases [5][6] - The collaboration includes an upfront payment and milestone payments, with over $200 million expected in the near term [6] - Novo Nordisk will cover all R&D expenses for the partnered programs, providing Septerna with operational flexibility [6] Pipeline Development - Septerna is advancing its PTH1R agonist program, with plans to select a candidate for clinical trials by the end of 2025 [5][6] - The SEP-631 program for mast cell diseases is expected to initiate a Phase 1 clinical trial in Q3 2025 [1][5] - The company is also progressing TSHR NAM lead compounds aimed at treating Graves' disease and thyroid eye disease [5] Financial Performance - For Q1 2025, Septerna reported a net loss of $21.5 million, compared to a net loss of $14.2 million in Q1 2024 [11][14] - R&D expenses increased to $19.3 million in Q1 2025 from $13.2 million in Q1 2024, while G&A expenses rose to $6.9 million from $2.7 million [11][14] - The total cash, cash equivalents, and marketable securities as of March 31, 2025, were $398.2 million, down from $420.8 million at the end of 2024 [11][16]

Thank you. Um I'm Jen from SK Terracon from South Korea and uh today I'd like to give a talk about the storage virtualization and optimization for GPU as a service that what we are trying to do recently. And uh first of all I think you are not quite familiar what is SQL.So I would like to give a brief like introduction to the SK talon. JSK is a novel metal player in South Korea and we made the most of the market penetrations in South Korea and recently we are trying to transform from the NNO to the AI compa ...

Tectonic Therapeutic (TECX) 2025 Conference May 15, 2025 12:20 PM ET Speaker0 Hey, everyone. Good morning, and welcome to day three of the twenty twenty five Bank of America Healthcare Conference. And thanks for joining this session with Tectonic Therapeutics. My name is Alex Stranahan. I'm senior biotech analyst at Bank of America. And I'm pleased to introduce Elise Raisin, president and CEO of Tectonic. She'll be running through some slides and going over the company. So with that, Elise, over to you. Spe ...

诺和诺德目前的市值自一年前的高位蒸发超过50%。就在两天前，礼来发表了一项"头对头"研究数据，显示该公司的GLP-1药物替尔泊肽的减重疗效全面超 越司美格鲁肽。 诺和诺德正在疯狂斥重资押注减重疗法，以占领新一代药物研发的先机。 欧洲当地时间5月14日，诺和诺德宣布，已与美国生物科技公司Septerna达成合作及授权协议，共同开发用于治疗肥胖症、2型糖尿病和其他心脏代谢疾病的 口服小分子药物，该协议的潜在价值预计高达22亿美元，其中包括2亿美元的预付款。 除了诺和诺德和礼来，罗氏也在大举押注减重药物。今年3月，罗氏宣布将斥资高达53亿美元，与Zealand Pharma公司共同开发并商业化一种被称为"长效胰 淀素类似物"的减重药物petrelintide。 在主要竞争对手礼来的步步紧逼下，诺和诺德目前的市值自一年前的高位蒸发超过50%。就在两天前，礼来发表了一项"头对头"研究数据，显示该公司的 GLP-1药物替尔泊肽的减重疗效全面超越司美格鲁肽。 投资者担心，诺和诺德最先上市的GLP-1类减重药司美格鲁肽将失去先发优势。自今年3月中旬以来，替尔泊肽减重药在美国的处方量不断上升，并超过了 司美格鲁肽。 与此同时， ...

Core Insights - The second "Hong Kong World Youth Science Conference" and the 2025 "Hong Kong Innovation and Technology Forum" were held in Hong Kong, featuring Nobel laureates and academicians from around the world, including the notable couple Edward and May-Britt Moser, who won the Nobel Prize in Physiology or Medicine in 2014 for their discovery of grid cells in the brain [1] Group 1: Discovery of Grid Cells - The Mosers discovered grid cells, which are crucial for the brain's spatial navigation system, functioning similarly to a GPS [2][3] - Grid cells create a geometric pattern in the brain, forming a grid-like structure that helps in spatial awareness and navigation [2][3] Group 2: Implications for Brain Science - The discovery of grid cells is significant as it reveals that the brain has an internal map that is not solely reliant on sensory input but is generated internally [3][4] - This internal navigation system is universal across humans and animals, but its effectiveness depends on how individuals anchor this map to stable external landmarks [6] Group 3: Alzheimer's Disease Research - The research on grid cells has opened new avenues for understanding neurodegenerative diseases, particularly Alzheimer's disease, which is characterized by early degeneration in the entorhinal cortex where grid cells are located [7][9] - The Mosers emphasize the need to focus on specific brain regions like the entorhinal cortex to understand the mechanisms behind Alzheimer's disease and develop potential treatments [10] Group 4: Cultural and Educational Exchange - The Mosers have engaged in significant collaborations with Chinese researchers, highlighting the importance of integrating Eastern and Western medical knowledge [12][13] - Their experiences in China have led to fruitful academic exchanges, including the development of innovative microscopy technology by a talented student from Peking University [14][15] Group 5: Gender Equality in Science - May-Britt Moser discusses the challenges of gender bias in science, advocating for a focus on individual capabilities rather than gender [17][18]

姚高员指出，推进数字政府2.0建设是落实习近平总书记重要指示要求的杭州实践，是政府系统刀 刃向内的重大改革，是提升超大城市治理现代化水平的现实需要。要依托杭州数字经济、数字技术和数 字化改革先发优势，围绕政府履职更高效、便民惠企更有感、基层减负更显著、应用场景更智能、数据 价值更释放、系统建运更节约的目标，坚持"系统谋划、稳慎推进，实战实效、好用管用，集约节约、 综合集成，安全可靠、自主可控"的原则，推动数字政府建设取得新进展新成效。 姚高员强调，要聚焦集约化，强化项目建设统筹管理，探索政务应用系统集约运维改革，建立动态 评估监管机制，打造数字政府节约高效建运模式。要聚焦实战化，全面承接用好省建应用，迭代优化一 批、谋划新建一批特色应用，打造具有杭州辨识度的标志性成果。要聚焦智能化，启动城市大脑 GPT、"数智公务员"建设，打响全国首个政务模型训练场"金字招牌"。要聚焦产业化，形成一批可复制 可推广的杭州典型应用、终端产品、技术体系、运维经验，探索数据要素资源化资产化的杭州模式。要 聚焦国产化，牢固树立底线思维，构筑数智安全防护"免疫体系"。各地各部门要进一步强化组织领导、 责任落实、推进协同，确保数字政府2 ...

金 融 期 货 研 究 2025 年 5 月 12 日 期指：短期偏强，关注实质性内容 【期指期现数据跟踪】 期指数据 | | 收盘价 | 涨跌幅% | 基 差 | 成交额-亿 | 成交量 | 变 动 | 持仓量 | 变 动 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 沪深300 | 3846.16 | ↓0.17 | | 2167 | | | | | | IF2505 | 3840.2 | ↓0.15 | -5.96 | 259.6 | 22554 | ↓8860 | 40133 | ↓6040 | | IF2506 | 3808.6 | ↓0.19 | -37.56 | 455.9 | 39940 | ↓19045 | 138820 | ↓7201 | | IF2509 | 3743.6 | ↓0.32 | -102.56 | 99.5 | 8861 | ↓4222 | 58536 | ↓984 | | IF2512 | 3706.8 | ↓0.42 | -139.36 | 24.6 | 2208 | ↓928 | 9288 | ...

本期内容转载自公众号「十分之一信箱」 朋友们，周日早上好！又到了我们放送好奇心的时间。看看过去两周，「Knock Knock 世界」又收到了哪些来 自少年听众的观察和疑问。 如果你也有感兴趣的问题，点击我们的选题投递箱入口：https://sourl.cn/uwvZsy，或者直接在「Knock Knock 世界」每期节目的评论区留言，把好奇心发送给我们。 为什么有的人会对花粉过敏？ -之前也有听众投递了花粉过敏的 选题。节目组也早早就安排上了，周 五已经上线了。记得收听哦。 现在部分改作业都是「AI老师」, AI老师来了,ChatGPT会取代人 类教师吗? 豆包比我算题算得快,英语比我 好,为什么我还要学习?尤其是学 习数学,为什么不都让 AI 去做题 计算好了,未来还需要学习那么 难的数学吗? 我想知道很多小朋友和大人的运 动鞋上的那个旋钮上都有的BOA 是什么?为什么不同牌子的鞋子 都有这个? 我在江苏南京,今年很少下雨,很 多地方出现了旱灾,为什么气象 部门不能经常开展人工增雨呢? 我快八周岁了,我好害怕死,也怕 爸爸妈妈会死。长生不老药到底 有没有研制成功?是不是很贵? 我看到现在商场里都有很多宠物 ...

作者 沈建缘 沈建缘/文 尽管关税风暴以及充满不确定性的市场环境对全球半导体产业产生持续的影响，尤其是对中国市场带来 巨大挑战，但中国AI产业的发展格局，也将对全球半导体产业链产生重要影响。 近日，摩根士丹利发布最新市场分析报告指出，中国在GPU领域的自给能力正在快速提升。该报告预 估，2024年中国人工智能GPU的自给率将达到34%。预计到2027年，这一数字将大幅跃升至82%。这意 味着，在短短三年内，中国GPU的自给能力将高速飞跃，从相当程度上依赖进口转向以国内供给为主。 此前据集微咨询统计，2025年1-3月，中国半导体器件、集成电路和半导体硅片进口额均同比有所上 升，半导体设备 进口额同比有所下降，3月，半导体器件、集成电路、半导体设备和半导体硅片进口额 均环比有所上升。 从重点商品来看，我国集成电路进出口额均同比增加，半导体设备进口额同比下降，出口额同比上升， 一方面全球半导体行业复苏，电子产品需求回暖，成熟制程需求旺盛，同时拉动集成电路的需求；另一 方面美国对华实行关税政策及技术限制促使国内厂商优先选择国产半导体设备。 中国GPU自给率的提升，与中国云端AI市场的爆发式增长密不可分。近日，国内独 ...

Investment Highlights - NextNav provides a next-generation PNT solution based on 5G technology[8] - The company possesses a valuable spectrum asset with ideal propagation characteristics for PNT and broadband[8] - NextNav has a robust balance sheet with ample liquidity to fund operations[8] GPS Vulnerability and NextNav's Solution - GPS has coverage limitations indoors and in urban canyons with weak signal strength[11] - GPS is vulnerable to spoofing, jamming, and natural phenomena[11] - NextNav's goal is a future-proof complement and backup to GPS, available at wide scale including indoor and urban areas[13] - NextNav's proposal uses its Lower 900 MHz licenses, in partnership with a 5G network provider, to enable a wide-scale terrestrial backup and complement to GPS, without taxpayer funding[17] FCC Petition and Economic Benefits - The Brattle Group finds the total quantified value of a terrestrial GPS backup is $14.6 billion[27] - Adopting NextNav's proposal offers the US economy a $10.8 billion insurance policy to protect against GPS outages without taxpayer funding, plus additional benefits of $3.8 billion from increased resiliency[30] - NextNav finished the first quarter with $188.4 million in cash, cash equivalents, and marketable securities[33]