Core Insights - Cibus has announced promising results from its third mode of action for Sclerotinia resistance in canola, which is expected to enhance crop yields and reduce fungicide usage for farmers [1][4] - The company's Rapid Trait Development System™ (RTDS) allows for efficient gene editing and development of plant traits that are indistinguishable from conventional breeding [2][7] - Cibus has completed edits in four modes of action for Sclerotinia resistance and anticipates completing field tests by the end of 2025 [3] Company Overview - Cibus is a technology company focused on gene editing to develop and license traits to seed companies, addressing productivity and sustainability challenges in agriculture [6][7] - The company is not a seed company but aims to improve productivity traits for major global crops such as canola, rice, and soybean [7] - Cibus has a pipeline of five productivity traits, including Sclerotinia resistance, which is a near-term focus [7] Industry Context - Sclerotinia sclerotiorum is a significant fungal pathogen affecting canola and other crops, causing yield losses of 7-15% and potentially up to 90% in severe cases [5] - The economic impact of diseases and pests in agriculture is estimated to cost the global economy approximately $300 billion annually [6][7] - The development of durable resistance traits is crucial as climate change affects the prevalence and distribution of crop diseases [4][5]

Financial Data and Key Metrics Changes - As of December 31, 2024, the company's cash, cash equivalents, and marketable securities were approximately $861.7 million, down from $1 billion as of December 31, 2023 [31] - Collaboration revenue for Q4 2024 was $12.9 million, a significant increase from negative $1.9 million in Q4 2023, driven mainly by the Regeneron license and collaboration agreement [31] - R&D expenses increased to $116.9 million in Q4 2024 from $109 million in Q4 2023, primarily due to advancements in lead programs [32] - G&A expenses rose to $32.4 million in Q4 2024 from $29 million in the prior year quarter, with stock-based compensation contributing to the increase [32] Business Line Data and Key Metrics Changes - The company is focused on late-stage programs, particularly NTLA-2002 for hereditary angioedema (HAE) and nex-z for transthyretin amyloidosis (ATTR), with significant enrollment progress expected [8][12] - Enrollment in the Phase III study for HAE (HAELO) is anticipated to be completed in the second half of 2025, while the MAGNITUDE study for ATTR is expected to exceed 550 patients by year-end [8][20] Market Data and Key Metrics Changes - The company sees substantial market opportunities in HAE and ATTR, with a focus on preparing for commercial phases as enrollment progresses [9][12] - The FDA granted nex-z Regenerative Medicine Advanced Therapy Designation (RMAT), facilitating closer collaboration as the company approaches a BLA filing in 2028 [26] Company Strategy and Development Direction - The company has prioritized resources on late-stage programs, discontinuing NTLA-3001 in favor of a second-generation approach [12] - The strategy includes building a commercial infrastructure in the U.S. for NTLA-2002, with plans for a successful launch in 2027 [30][110] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the trajectory of operating expenses, expecting a decline of approximately 5% to 10% year-over-year due to restructuring efforts [34][48] - The company anticipates that peak operating expenses are behind them, with a steady state expected by 2026 as enrollment in studies completes [48] Other Important Information - The company welcomed Birgit Schultes as the new Chief Scientific Officer, bringing over 20 years of experience in drug development [14] - Management highlighted the importance of achieving a functional cure for patients with HAE, which is a key driver for market interest [155] Q&A Session Summary Question: Update on OpEx decline and restructuring - Management indicated that operating expenses were up 7% year-over-year, but restructuring efforts are expected to lead to a decline in future expenses [42][48] Question: Phase III events accrual rate for nex-z - Management noted that enrollment is ahead of projections and expects favorable findings at the interim analysis [60] Question: Competition from Alnylam's next-generation TTR silencer - Management acknowledged the competitive landscape but emphasized their unique approach and data supporting their therapy's efficacy [66][70] Question: Confidence in enrolling 550 patients for ATTR cardiomyopathy trial - Management expressed high confidence in achieving the enrollment target by year-end, citing robust enrollment rates [79] Question: Commercial approach for HAE - Management discussed the straightforward treatment regimen and ongoing efforts to ensure favorable reimbursement environments [85][89] Question: Long-term follow-up for HAE patients - Management indicated that all patients have shown improvement, and they expect to report on longer-term data later this year [96][97] Question: Preparations for BLA filing - Management confirmed that they are on track for a BLA filing in 2026, with favorable interactions with the FDA [106] Question: Sales force size for NTLA-2002 launch - Management refrained from specifying the sales force size but expressed confidence in operationalizing the market opportunity [110] Question: Long-term observation data for HAE - Management indicated that they will follow patients closely and expect to submit a supplemental BLA soon after initial approval [117]

Table of Contents As filed with the Securities and Exchange Commission on January 16, 2024. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 KYVERNA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2836 83-1365441 (Primary Standard Industrial Classification Code Number) 5980 Horton St., STE 550 (I.R.S. E ...