智通财经APP获悉，特朗普关税风波变数再起，港股全天承压走低，恒科指一度跌近3%。截止收盘， 恒生指数跌1.2%或283.61点，报23289.77点，全日成交额为2715.63亿港元；恒生国企指数跌1.49%，报 8432.02点；恒生科技指数跌2.48%，报5170.43点。全月来看，恒指累涨5.29%，国指累涨4.41%，恒科 指累涨1.63%。 光大证券指出，当前恒生指数估值处于中等偏低位置，而恒生科技指数估值正处于历史低位，从估值角 度来看，港股具有较高的投资性价比。在国内政策积极发力，以及海外扰动减弱的双重支撑下，港股市 场有望延续震荡回升格局。可关注科技成长及高股息占优的"哑铃"策略。 蓝筹股表现 石药集团(01093)领涨蓝筹。截至收盘，涨6.3%，报8.1港元，成交额49.5亿港元，贡献恒指6.53点。石药 集团今日盘前公布，正与若干独立第三方就三项潜在授权合作进行磋商，涉及集团旗下若干产品及基于 其技术平台开发药品的开发、生产及商业化。每项交易可能带来的首付款、开发里程碑付款及商业化里 程碑付款总额最高可达约50亿美元。 其他蓝筹股方面，理想汽车-W(02015)涨3.79%，报112.3 ...

此外，5月30日-6月3日，2025年美国临床肿瘤学会（ASCO）年会将在美国芝加哥举行。今年ASCO年 会上，中国研究者共计70余项原创研究入选口头报告。太平洋证券表示，流动性和风险偏好提升，数据 和BD催化有望成为全年主线。交银国际研报指出，ASCO大会召开在即，LBA重磅数据即将揭晓，创 新药板块有望迎来关注热潮、并有望在未来推动更多出海交易达成，市场情绪与板块估值将进入正向修 复通道。 智通财经APP获悉，医药股再度走高，截至发稿，中国抗体-B(03681)涨18.85%，报1.45港元；宜明昂 科-B(01541)涨17.54%，报13.4港元；昭衍新药(06127)涨14.96%，报14.6港元；歌礼制药-B(01672)涨 12.25%，报7.97港元；和铂医药-B(02142)涨5.03%，报9.18港元。 消息面上，石药集团今日盘前公布，正与若干独立第三方就三项潜在授权合作进行磋商，涉及集团旗下 若干产品及基于其技术平台开发药品的开发、生产及商业化。每项交易可能带来的首付款、开发里程碑 付款及商业化里程碑付款总额最高可达约50亿美元。此前不久，三生制药宣布与辉瑞就PD-1/VEGF双抗 药物 ...

Group 1 - The Hong Kong stock market experienced a significant pullback on May 30, yet the innovative drug sector saw gains, with notable increases in stocks such as CSPC Pharmaceutical rising over 8% and others like Fosun Pharma and Zai Lab increasing over 5% [1] - The Hong Kong innovative drug ETF (159567) attracted over 200 million yuan in net inflows over the past 20 trading days, indicating high market interest [1] - The development of innovative drugs in China is driven by the transformation of generic drug companies and the emergence of biotech firms, supported by unmet clinical needs and the urgency of multinational pharmaceutical companies to fill their pipelines as they approach patent cliffs [1] Group 2 - The innovative drug ETF (159567) tracks the National Index of Hong Kong Innovative Drugs, with 90% of its weight in innovative drug companies, positioning it to benefit from trends such as AI-enabled drug development and the international expansion of domestic innovative drugs [2] - The innovative drug ETF (159992) encompasses leading companies in the innovative drug industry chain, benefiting from both AI advancements and the introduction of new healthcare policies targeting high-priced innovative drugs [2] - The investment value of domestic innovative drug companies is increasingly highlighted in the current market environment, with recent sector pullbacks attributed more to external policy expectations rather than fundamental changes [2]

Group 1 - The Hong Kong biopharmaceutical sector experienced a collective rise, with WuXi Biologics (02269.HK) and Junshi Biosciences (01877.HK) leading the gains, both increasing over 9% [1] - Other companies such as WuXi AppTec (02359.HK), Kanglong Chemical (300759.HK), Kelun Pharmaceutical (06821.HK), and Tigermed (03347.HK) also saw increases of 4%-5% [1] Group 2 - A significant ruling by the U.S. International Trade Court on May 28 declared the "day of liberation" tariff policy from the Trump administration unconstitutional, reducing policy uncertainty for Chinese pharmaceutical companies looking to expand overseas [3] - The ruling emphasized that the U.S. Constitution grants Congress exclusive power to regulate trade, limiting presidential authority in economic security matters [3] Group 3 - The first quarter of 2025 saw a surge in License-out transactions, totaling 41 deals worth approximately $36.93 billion, nearing the total for the entire year of 2023 [3] - Notable transactions included 3SBio's $12.5 billion upfront payment plus up to $4.8 billion in milestone payments to Pfizer for a PD-1/VEGF dual antibody drug [3] Group 4 - The upcoming ASCO annual meeting in Chicago is expected to showcase the international competitiveness of Chinese innovative drugs, with 71 studies from Chinese companies selected for oral presentations [4] - Key clinical data will be released by several prominent companies, including Innovent Biologics and China Biologic Products, which may reshape treatment standards for non-small cell lung cancer [4][5] Group 5 - The progress of ADC drugs developed by partners of WuXi Biologics and collaborations between Kelun Pharmaceutical and Merck is also attracting attention [5] - The increasing quantity and quality of results presented by Chinese pharmaceutical companies at top academic platforms like ASCO indicate a recognized research and development capability in oncology [5]

作者 | 哥吉拉 数据支持 | 勾股大数 据（www.gogudata.com） 5月29日，A股主要指数高开高走，截至收盘，沪指涨0.7%报3363点，深证成指涨1.24%，创业板指涨1.37%。全市场近4500股上涨，逾百 股涨停。 板块方面，金融科技、创新药、互联网、半导体等热门板块表现强势，市场情绪相比近日明显提振。 其中，创新药是涨幅最明显的板块之一，睿智医药、舒泰神、益方生物强势斩获20CM涨停，另有十多家医药股涨幅均超过10%，堪称又一轮 暴涨潮。 | 代码 | 名称 | 现价 | 1 9 mm a lond a rither more an a many 143 1994 (310 1 涨跌幅▼ | 年初至今涨跌幅 | 总市值1 | | --- | --- | --- | --- | --- | --- | | 300149 | 睿智医药 | 8.56 c | 20.06% | 33.33% | 43亿 | | 300204 | 舒泰神 | 23.04 c | 20.00% | 210.93% | 110亿 | | 688382 | 益元生物-U | 29.10 c | 20.00% | 11 ...

Core Viewpoint - The recent high-value transaction involving the innovative drug SSGJ-707 by 3SBio and Pfizer highlights the growing trend of Chinese biopharmaceutical companies expanding into international markets, despite challenges in the global pharmaceutical environment [2][4]. Group 1: Transaction Details - Pfizer has made a non-refundable upfront payment of $1.25 billion (approximately 9 billion RMB) for the rights to SSGJ-707 outside of China, with potential milestone payments totaling up to $4.8 billion (approximately 34.5 billion RMB) and an additional $100 million for equity subscription [2]. - This transaction sets a record for the upfront payment for a Chinese innovative drug going overseas, indicating a significant shift in the landscape of biopharmaceutical transactions [4]. Group 2: Company Background - 3SBio, established in 1993, is a well-established pharmaceutical company that went public on NASDAQ in 2007 and later privatized before listing on the Hong Kong Stock Exchange in 2015 [3]. - The subsidiary involved in the transaction, 3SBio Guojian, was formerly known as CITIC Guojian and is recognized as one of the earliest companies in China to engage in antibody drug research and sales [3]. Group 3: Market Trends - The trend of Chinese innovative drug companies seeking international partnerships has been growing, with a nearly 40% increase in outbound business development (BD) transactions since 2022, projected to reach around 120 deals worth approximately $63 billion in 2024 [6]. - The stock prices of 3SBio and 3SBio Guojian have surged over 200% and 130%, respectively, following the announcement of this transaction, reflecting strong market interest in innovative drug development [4]. Group 4: Strategic Implications - The increasing trend of "going overseas" is reshaping the clinical research strategies of domestic innovative drug companies, with many now considering international transactions as a key part of their development plans [4]. - The shift from a "me too" model to a focus on first-in-class (FIC) drugs is evident, as domestic companies are increasingly competing head-to-head with multinational pharmaceutical firms [4][5].

Core Insights - The Hong Kong stock market saw a significant surge in the innovative drug sector, with major stocks like WuXi AppTec and Junshi Biosciences experiencing gains of over 8% [1] - The total transaction amount for domestic innovative drugs reaching overseas has hit $45.5 billion this year, with an upfront payment of $2.2 billion, indicating a strong growth trajectory [1] - The price-to-earnings ratio of the Hong Kong innovative drug index has decreased from 64 times in February to 27 times, highlighting an attractive valuation for investors [1] Group 1: Market Performance - The Hong Kong innovative drug ETF (159567) rose over 2%, with real-time trading volume exceeding 500 million yuan, reflecting high market activity [1] - The average daily trading volume over the past five trading days for the innovative drug ETF was 699 million yuan, indicating strong investor interest [1] Group 2: Industry Trends - The innovative drug sector is benefiting from increased health awareness and an aging population, leading to a growing demand for pharmaceuticals [1] - The innovative drug ETF (159992) tracks a comprehensive index that includes both global CXO leaders and domestic generic drug companies, positioning it to benefit from various market trends [2] - The retail market for prescription drugs in China continues to grow steadily, with biological products and innovative drugs being the main drivers of this growth [2]

截至2025年5月29日 10:05，上证科创板100指数(000698)强势上涨1.63%，成分股博瑞医药(688166)上涨9.66%，智翔金泰(688443)上涨6.57%，三生国健 (688336)上涨6.04%，安路科技(688107)，泽璟制药(688266)等个股跟涨。科创100指数ETF(588030)上涨1.60%，最新价报0.95元。流动性方面，科创100指数 ETF盘中换手1.16%，成交7155.68万元。拉长时间看，截至5月28日，科创100指数ETF近1年日均成交4.24亿元，排名可比基金第一。 华福证券认为"量变引起质变"是最朴素的真理，中国创新药已经从模仿到快速跟随到源头创新。从BD交易金额来看：2025年初至今创新药出海交易总金额 已达455亿美元，首付款已达22亿美金，25全年有望创新高。从产业和公司发展周期的角度去看：新药放量+Biotech逐步减亏盈利+重磅BD频出催化的年初 至今的创新药大行情已经说明了中国创新药完成了0-1的过程，正在走向1-10国际化的快速发展过程中，未来中国创新药出海交易仍然值得期待。从药品研 发周期的角度：目前绝大部分国内出海的创新药在美国处于 ...

Core Viewpoint - The company has granted Pfizer exclusive rights to develop, produce, and commercialize a dual-targeting antibody product aimed at PD-1 and VEGF, which is expected to enhance anti-tumor effects while reducing potential side effects [1][3]. Group 1: Licensing Agreement - Sanofi Health has granted Pfizer exclusive rights for the development and commercialization of the 707 project in regions outside mainland China [1]. - The licensing agreement involves a distribution of rights based on prior R&D investments and asset ownership, with Sanofi Health receiving 30% and Shenyang Sanofi receiving 70% [2]. Group 2: Clinical Development - The efficacy and safety of the PD-1/L1 antibody combined with VEGF antibody have been validated in clinical trials for various tumors, including renal cell carcinoma and hepatocellular carcinoma [3]. - The product has multiple ongoing clinical trials, with a single-agent treatment for PD-L1 positive non-small cell lung cancer having received approval for Phase III, while combination therapies for non-small cell lung cancer, metastatic colorectal cancer, and advanced gynecological tumors are in Phase II [3]. Group 3: Financial Projections - Following the significant licensing agreement and the anticipated approval of new products, the company has adjusted its revenue forecasts for 2025-2027 to 40.2 billion, 22.4 billion, and 26.3 billion yuan, reflecting a year-on-year growth of 236.4%, -44.1%, and 17.4% respectively [4]. - The projected net profits for the same period are 28.5 billion, 11.2 billion, and 13.9 billion yuan, with year-on-year growth of 305.0%, -60.6%, and 23.4% respectively [4]. - Earnings per share (EPS) are expected to be 4.63, 1.82, and 2.25 yuan, with corresponding price-to-earnings (PE) ratios of 12, 30, and 24 times based on the closing price of 54 yuan per share on May 28, 2025 [4].

究其背后的原因，此前5月20日，三生制药与辉瑞达成PD-1/VEGF双抗SSGJ-707全球权益合作的消息，不断强化着市场对中国创新药企技术输出能力的信 心。同时近期多家中国创新药企业宣布将在5月30日至6月3日举办的2025年美国临床肿瘤学会 （ASCO）年会上发布研究成果，市场对国产创新药出海及技 术授权合作的预期被放大， 医药板块热度被进一步提升，作为在抗肿瘤药领域布局的海王生物，正与行业热度形成共振。 2025年5月27日，医药代表型企业海王生物（000078）迎来2025年的首次涨停，当日参与资金达到1.75亿元，成交量较前一个交易日有近三倍的增长，呈典 型的放量冲涨态势。 从区域流通商到生物科技平台的进化史 在生物医药行业这片充满技术壁垒与政策护城河的战场中，中国药企正经历着从"仿制跟随"到"创新领跑"的基因突变。在政策变革、技术迭代与市场洗牌 中，始终保持着对行业本质深刻理解的海王生物，已从深圳蛇口的一家初创企业，成长为覆盖医药研发、制造、流通全产业链的综合性集团，演绎着从传统 药企向生物科技平台跃迁的资本叙事。 1992年成立的海王生物发展历程，可以说是中国医药流通行业集约化进程的缩影。199 ...