Core Viewpoint - VYNE Therapeutics Inc. is advancing its VYN202 program for treating moderate-to-severe plaque psoriasis after the FDA lifted a clinical hold for female patients on lower doses, while further data is needed for male subjects [1][2][4] VYN202 Program Update - The FDA placed a clinical hold on the Phase 1b trial due to testicular toxicity observed in dogs, but has now lifted the hold for female patients on 0.25 mg and 0.5 mg doses [2] - The 1 mg dose was excluded from the revised protocol due to a lower safety margin [2] - A 12-week non-clinical toxicology study is required to resume trials in male subjects, with the study design agreed upon with the FDA [2] Clinical Data Insights - The clinical data from the Phase 1b trial included 7 enrolled subjects, with 6 treated with VYN202 and 1 with placebo [3][5] - No serious adverse events or treatment discontinuations were reported, and all subjects treated with VYN202 showed improvement in psoriasis symptoms [7] - PASI scores improved by approximately 27% after 1 week and up to 90% by week 8 [7] - Significant reductions in serum cytokine levels were observed in subjects treated with VYN202, while no changes were noted in the placebo group [7] Future Plans and Financial Outlook - The company will not enroll new patients in the Phase 1b psoriasis study, extending its expected cash runway into Q4 2026 [4] - Further updates on the VYN202 program will follow the release of top-line results from the ongoing Phase 2b study of repibresib gel for non-segmental vitiligo [4] About VYN202 - VYN202 is an oral small molecule BET inhibitor with potential class-leading selectivity and potency for BD2, aimed at providing a non-biologic treatment option for immuno-inflammatory conditions [10] About VYNE Therapeutics Inc. - VYNE is focused on developing differentiated therapies for chronic inflammatory and immune-mediated conditions, leveraging its proprietary BET inhibitors to overcome limitations of earlier generations [11]

Core Insights - Cyngn has successfully raised $32 million in capital, enhancing its financial stability and supporting growth plans without immediate need for further capital [2] - The company's autonomous DriveMod technology is operational in various industrial settings, improving safety, productivity, and labor costs [3][8] - Cyngn is expanding its headquarters to accommodate increased product development and demonstration needs, aided by a partnership with NVIDIA [4][8] Technology and Product Development - DriveMod technology is designed for Tuggers and Forklifts, with capabilities to handle significant loads and a payback period of less than two years [9] - The company has secured 23 patents, indicating a strong focus on innovation within its engineering and R&D teams [5] - Advanced generative AI is being integrated into R&D and product development processes, enhancing efficiency and innovation [6] Market Position and Strategy - Cyngn's autonomous vehicles are becoming integral to operations in manufacturing, automotive, logistics, and consumer-packaged goods sectors, providing clients with a competitive edge [3][8] - The company aims to convert its current momentum into scalable growth while maintaining discipline and long-term focus [7]

Autonomous driving has been in the news quite a bit lately, with Tesla launching its robotaxi service in Austin, Texas. While I think Tesla is a great pick in this space, there's one that I like more at the moment. That's Alphabet (GOOG -0.27%) (GOOGL -0.22%). Alphabet is known as the parent company of Google, but it also owns Waymo, the undisputed leader in autonomous driving right now (at least in terms of deployed footprint). Alphabet is my top autonomous driving stock, and investors can essentially acqu ...

Group 1 - The semiconductor materials ETF (562590) closely tracks the CSI Semiconductor Materials and Equipment Theme Index, which includes 40 listed companies deeply involved in the semiconductor materials and equipment sectors [2] - The index comprises leading companies that have shown significant performance in the domestic substitution process, such as North Huachuang and Zhongwei Company in the etching equipment sector, and Hushi Industry and Nanda Optoelectronics in key materials [2] - The sample selection focuses on core industry tracks, reflecting the trend of self-reliance and upgrading in the semiconductor industry chain, and represents the overall performance of listed companies in semiconductor materials and equipment [2] Group 2 - As of July 2, 2025, the CSI Semiconductor Materials and Equipment Theme Index (931743) fell by 1.99%, with notable declines in stocks such as Zhongke Feimeng down 5.84% and Zhongjing Technology down 4.79% [1] - The NAND Flash market price index increased by 9.2% and the DRAM market price index surged by 47.7% from the beginning of 2025 to the present, indicating a significant market shift [1] - The traditional DRAM products experienced a dramatic reversal from oversupply in the second half of 2024 to a shortage in the first half of 2025, impacting both server and consumer terminal markets [1]

点击下方 卡片 ，关注" 自动驾驶之心 "公众号 戳我-> 领取 自动驾驶近15个 方向 学习 路线 世界模型Epona 地平线、清华、北大等团队ICCV'25中稿的自回归扩散世界模型工作，同时可以不依赖视频预测独立输出轨 迹规划。 主要贡献： 论文标题：Epona: Autoregressive Diffusion World Model for Autonomous Driving 论文链接：https://arxiv.org/abs/2506.24113 项目主页：https://kevin-thu.github.io/Epona/ 长时序生成。Epona可以实现长达2分钟的长时间生成，显著优于现有的世界模型； 实时轨迹规划。独立的多模态生成架构能够在视频预测不可用的情况下独立输出轨迹规划，从而显著降 低了推理FLOPS。这实现了高质量甚至实时的轨迹规划，高达20Hz的帧率； 视觉细节的保存。Epona的自回归公式采用连续视觉标记器而不是离散标记器，从而保留了丰富的场景 细节； 可视化： 算法框架： 实验结果： | Metric | | | | DriveGAN [30] DriveDreamer [5 ...

" 威海移动房交会 " 天津专场。资料图 本次活动由山东省住房和城乡建设厅指导，山东省房地产业协会、上海市房地产经纪行业协会支持，威海市住房和城乡建设局主办，威 海市房地产业协会、中国工商银行股份有限公司威海分行、中国农业银行股份有限公司威海分行、中国银行股份有限公司威海分行协 办，威海盈润地产承办。 齐鲁晚报·齐鲁壹点记者 孟杰 7月3日，"山海浪漫·精致温暖——威海国际滨海旅行目的地精品楼盘推介会"即将走进上海。此次活动是"威海移动房交会"的第十一站， 旨在展示推荐威海的精品楼盘，让更多向往滨海浪漫生活的上海人，能够更加轻松选择到最适合养生、度假、安居的品质居所。 据威海市住房和城乡建设局相关负责人介绍，此次参与推介的10家房地产企业和项目均由威海市住房和城乡建设局筛选确定，同时满足 了房地产项目施工进度在单体竣工以上，参会开发企业为市房地产开发企业信用评价A 级以上企业两个要求。"这次上海之行，我们将推 出涵盖高端海景房、低密花园洋房、改善社区、康养旅居等多元业态的精品项目，想让更多向往滨海浪漫生活的上海人，能够更加轻松 地选择到最适合养生、度假、安居的品质居所；同时，也是希望能推动企业抱团取暖，整合各 ...

The biggest story in June concerning autonomous driving was Tesla's long-awaited robotaxi launch, but the news surrounding Uber Technologies (UBER -1.19%) could have a bigger impact in the near term. Shares of Uber climbed 10.9% in June, according to data provided by S&P Global Market Intelligence, on investor excitement about the company offering autonomous rideshare services in a second major U.S. market. Uber and Waymo extend their alliance Uber is perhaps the biggest name in ridesharing and initially ha ...

与其讨论同样的idea别人为什么能中顶会，不如讨论在同样的idea下顶会的论文究竟强在哪里？ 1. 是否为一个point solution？ 同样的idea ，如果单纯把某些指标刷的很高那多半中不了顶会。那就是point solution，本身而言不具备太大的影响力。 顶会的成果，绝大部分不单纯只 能用在某个特定的地方，这至少一个系列的方法。 那么对于想要快速有科研成果的小伙伴来说， 最重要的问题莫过于如何能高效、精准、短平快地中稿，特别是中稿顶会。 在前沿且复杂的自动驾驶、具 身智能、机器人领域，没有专业的领路人发顶会真的很难！ 为此，我们为有需要的小伙伴推出了深度辅导，面向计算机全领域及AI4s领域，提升论文中稿率，直至拿下顶会！ 能中的文章才是好文章， 咨询更多扫码添加： 适用人群 我们能提供什么？ 2. 文章的方法实现起来是否困难？ 同样的idea，但是别人的论文实现无难度，效果还杠杠的；或者实现起来虽然很复杂，但是使用起来很容易，这样的论文不中什么样的论文中? 从idea、实验设计、数据集选择、跑通baseline最后到初稿的写作， 任何一个环节的细微差别都会导致最后投稿区位的巨大不同。 清晰的科研 ...

Taxi evolution until Robotaxi https://t.co/tfNOMLYg2t ...

Core Insights - Electric vehicle (EV) stocks are projected to have significant growth, with EV sales expected to make up nearly one-third of new car sales in the U.S. by 2030, up from 3.4% in 2021 [1] Company Positioning - Tesla is well-positioned in the EV market due to its superior funding and a diverse product lineup compared to competitors [2] - The company has maintained profitability nearly every quarter for the past five years, while competitors like Lucid and Rivian remain unprofitable [5] - Tesla's market cap of $1 trillion allows it to raise substantial capital, providing a significant advantage over smaller competitors [5] Growth Opportunities - Tesla's recent launch of a robotaxi service in Austin, Texas, represents a new growth opportunity, with plans to develop Cybercabs specifically for autonomous taxi services [9] - Analysts predict that the global robotaxi market could be valued between $8 trillion to $10 trillion, with a significant portion of Tesla's market cap potentially attributed to this division [10] - The robotaxi opportunity could add $1 trillion to Tesla's market cap by the end of 2026, suggesting over 100% upside potential [11] Long-term Outlook - The full realization of the robotaxi opportunity is expected to unfold over decades, but the immediate growth potential is evident, making Tesla an attractive long-term investment [12]