Investment Rating - The report maintains a strong confidence in the pharmaceutical sector, particularly in innovative drugs, predicting a reversal trend in 2025 [4] Core Viewpoints - The innovative drug sector is experiencing strong performance driven by multiple factors, including the completion of quarterly portfolio adjustments, increased policy support from the National Healthcare Security Administration (NHSA) and the National Health Commission, and significant collaborations in the industry [1][11] - The NHSA and the National Health Commission have jointly released measures to support the high-quality development of innovative drugs, which will accelerate the commercialization of domestic innovative products and create a positive cycle of profitability and strong R&D investment [20][21] - The report highlights the potential of dual/multi-target antibodies in cancer treatment and innovative drugs addressing unmet clinical needs in chronic diseases as key investment opportunities [1][4] Summary by Sections Innovative Drugs - The innovative drug sector remains the main investment line, with a focus on dual/multi-target antibodies for various cancers and chronic diseases [1][11] - AstraZeneca is in talks for a collaboration worth up to $15 billion for the AK112 drug, which has catalyzed strong performance in related stocks [1] Pharmaceutical Sector - The NHSA's new measures will direct more healthcare resources towards innovative drugs, enhancing their commercialization and profitability [20][21] - The report notes that since 2018, 149 innovative drugs have been included in the healthcare insurance directory, significantly increasing the proportion of new drugs covered [22] Biologics - Changchun High-tech's new drug, Vuxin Qibai monoclonal antibody, has been approved for treating acute gout arthritis, marking a significant advancement in biologics [29][34] - The drug shows rapid onset of action and a substantial reduction in recurrence risk, highlighting its clinical significance [33][34] Traditional Chinese Medicine - Lingrui Pharmaceutical's new indication for its nasal spray is expected to boost sales, with ongoing efforts to expand hospital coverage and OTC sales [38][41] Medical Devices - The report emphasizes policy support for high-end medical devices, predicting accelerated commercialization in various segments such as medical robots and AI [3][4] Medical Services - Recent policies to enhance maternity benefits are expected to stimulate demand in related services [3][4]

Core Viewpoint - Brainlab, a leading company in the German medical technology sector, has unexpectedly postponed its IPO plans due to ongoing geopolitical uncertainties affecting capital markets, despite having received oversubscription for the offering [2][4]. Company Overview - Founded in 1989 and headquartered in Munich, Germany, Brainlab specializes in developing image-guided surgery, radiation therapy, and digital operating room solutions, with a core philosophy of "software-defined medicine" [7]. - The company has installed over 5,000 systems globally, covering 85 countries, and holds a 60% market share in the neurosurgery navigation field, being recognized as the "gold standard" in surgical navigation [7]. IPO Details - Brainlab planned to issue 2 million new shares and transfer up to 3.2 million existing shares, with a pricing range of €80-100, aiming to raise approximately €416 million [2]. - The overall valuation of the company was estimated at around €1.7 billion (over 14.3 billion RMB) [2]. Financial Position - The company emphasized that its cash flow situation does not rely on IPO funding for organic growth, providing financial confidence for the postponement [5]. - Brainlab participated in a €27 million Series A funding round for neurosurgical robotic developer Robeauté, indicating its strong cash flow position [5]. Management Perspective - CEO Rainer Birkenbach stated that the current geopolitical uncertainties and market volatility led management to believe that it was not the optimal time for the IPO, despite positive business performance in the previous quarter [4]. Market Impact - Brainlab is the second German company to postpone its IPO this year, following Autodoc, which has negatively impacted the IPO market in Germany and Europe [10]. - A survey indicated that 74% of European investment bankers expect an increase in IPO activity in 2025, but uncertainties from the German elections and potential U.S. tariffs are affecting market confidence [10]. - The DAX index has risen by 15.63% this year, while the expected growth rate for the real economy is only 0.2%, highlighting a divergence between capital markets and the real economy [10]. Strategic Considerations - The case of Brainlab illustrates that even in favorable conditions such as oversubscription, strategic determination and timing are crucial considerations for capital operations in the medical technology sector [11].

Core Viewpoint - The introduction of a "zero tariff" policy for imported medical devices and drugs in the Boao Lecheng International Medical Tourism Pilot Zone is facilitating the rapid entry of advanced medical technologies and products, benefiting both domestic and international patients [2][3]. Group 1: Policy Implementation - The "zero tariff" policy for imported medical devices and drugs was officially implemented on December 25, 2024, following the issuance of management measures by the Hainan provincial government [3]. - The Lecheng Pilot Zone has successfully integrated multiple departments to streamline the application process for "zero tariff" imports, reducing the administrative burden on medical institutions [4][6]. Group 2: Clinical Applications - The first clinical use of the Nexa smart cochlear implant system occurred at the Tree Lan (Boao) Hospital, with 50 units purchased, valued at approximately 15 million yuan, resulting in over 1 million yuan in tax exemptions [2][4]. - As of July 5, 2024, approximately 50 surgeries have been completed using the Nexa system, showcasing the immediate impact of the new policy on patient care [2]. Group 3: Regulatory Innovations - A comprehensive tracking management platform has been established to facilitate the application for "zero tariff" imports, allowing medical institutions to submit requests without leaving the hospital [3][4]. - The platform has enabled real-time data sharing between customs and medical institutions, enhancing efficiency and reducing redundancy in the application process [4][6]. Group 4: Future Developments - Continuous optimization of the platform and mechanisms is planned to expand the range of eligible medical devices and drugs, aiming to maximize the benefits of the policy for a larger population [7].

Core Viewpoint - The company, Shanwaishan, is experiencing growth in its blood purification equipment sales and is well-positioned in the expanding domestic blood dialysis market due to increasing ESRD patient numbers and supportive government policies [2][3][5]. Industry Overview - The number of ESRD patients in China increased from 3.025 million in 2019 to 4.126 million in 2023, with a compound growth rate (CGR) of 8.1%, which is significantly higher than the global growth rate of 5.1% [2]. - The percentage of ESRD patients receiving dialysis treatment in China is approximately 26%, which is below the global average of 37% and significantly lower than the average of 75% in developed countries, indicating substantial market potential for blood dialysis services [2]. Company Performance - In Q1 2025, Shanwaishan's blood purification equipment achieved revenue of 127.49 million yuan, with strong growth in both domestic and international markets [3]. - The company's blood purification consumables generated revenue of 43.26 million yuan in Q1 2025, with a year-on-year growth of 123.46% [5][6]. - The medical services segment reported revenue of 16.27 million yuan in Q1 2025, reflecting a year-on-year increase of 43.52% [6]. Competitive Advantages - Shanwaishan maintains a strong competitive edge through technological innovation, product quality, brand influence, and rapid service response [4]. - The company has established a national-level technology innovation platform and a comprehensive quality management system, ensuring product safety and reliability [4]. - As the only Sci-Tech Innovation Board listed company in the blood purification industry, Shanwaishan's brand recognition is increasing, enhancing market trust and acceptance [4]. Market Trends and Policies - The Chinese government is promoting policies to enhance the efficiency of medical equipment funding and reduce financing costs for equipment updates, which is expected to increase demand for blood dialysis equipment in hospitals [5][6]. - The company is actively monitoring and participating in the implementation of relevant procurement policies to capitalize on market opportunities [6].

转载与合作可联系证券时报小助理，微信ID：SecuritiesTimes END 点击关键字可查看 中共中央政治局委员、国务院副总理刘国中3日至5日到广东调研。他强调，要深入学习贯彻习近平总书记 关于"三农"工作和卫生健康工作的重要论述，按照党中央、国务院部署，加快推进农业和医疗领域科技创 新，因地制宜发展农业新质生产力，提升药品医疗器械自主创新能力，有力促进产业提质升级和经济高质 量发展。 刘国中先后来到深圳市、广州市，深入港口码头、科创中心以及农业、农机、电子、跨境电商等企业，实 地了解农业科技创新、农业产业发展、农民工稳岗就业等进展情况。 他强调，要以产业急需为导向，瞄准 种业、农机、饲料、种植养殖技术等重点领域，推进农业科技协同创新。要加快农业科技成果转化，推动 先进适用技术大面积集成推广，发挥农业科技为农服务、联农带农的重要作用。 要积极支持发展智慧农 业，推广农用无人机等新型农机装备，提高农业生产效率。要大力发展农产品精深加工，延伸农业产业链 价值链，提升农业综合效益。 要加强跟踪监测、就业指导和技能培训，帮助脱贫人口和农民工稳岗就业。 刘国中还走访了医疗器械研发生产企业，详细了解产品创新及应用情 ...

证券研究报告 | 2025年07月05日 **ACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACKACK ...

Core Viewpoint - The event "2 in 20,000 Encounters - The First National Public Welfare Science Popularization Art Exhibition on Tenosynovial Giant Cell Tumor (TGCT)" aims to raise awareness about TGCT, a rare disease affecting approximately 60,000 new cases annually in China, highlighting its impact on patients' daily lives and mobility [1][2]. Group 1: Disease Overview - TGCT is a non-malignant, locally aggressive tumor primarily affecting individuals aged 20-50, leading to symptoms such as joint swelling, pain, stiffness, and limited mobility [1][2]. - The disease is often misdiagnosed due to its non-specific symptoms, which can resemble other conditions like ganglion cysts and osteoarthritis, resulting in delayed treatment for many patients [2]. Group 2: Treatment and Clinical Needs - Surgical intervention remains the primary treatment for TGCT, with an overall recurrence rate of approximately 46.8% and a median recurrence time of about 12.9 months [2]. - There is a significant unmet clinical need for safe, effective systemic treatments, especially for patients with diffuse TGCT, who face challenges of recurrence and complications [2]. Group 3: Awareness and Community Involvement - The event aims to mobilize social forces and increase public participation in rare disease awareness, emphasizing the need for collaboration among government, medical institutions, enterprises, charitable organizations, and society to build a sustainable ecosystem for rare disease prevention and treatment in China [3].

Group 1 - The year 2025 is widely regarded as a critical juncture for the development of precision medicine, with advancements in biopharmaceuticals and innovative therapies driving significant changes in drug development [1][3] - The rapid development of artificial intelligence (AI) technologies is expected to reshape human health and disease treatment possibilities, enhancing the market growth potential of new therapies such as cell and gene therapy, bispecific antibodies, and antibody-drug conjugates (ADCs) [1][3] - The first domestic stem cell drug in China was approved for market release in January this year, with multiple stem cell therapies entering Phase III clinical trials, indicating a significant advancement in the field [3][5] Group 2 - The biopharmaceutical industry in China has experienced robust growth over the past decade, with innovative biopharmaceuticals becoming increasingly accessible [5][6] - China is achieving breakthroughs in cutting-edge technologies such as dual-target agonists, bispecific antibodies, and dual-load ADCs, positioning itself for a competitive edge in global drug development [5][6] - The approval of the weight-loss drug Ma Shidu Peptide, the world's first GCG/GLP-1 dual-target weight-loss medication, exemplifies the advancements in innovative drug development in China [5][6] Group 3 - The integration of AI tools in life sciences is becoming indispensable, with breakthroughs in induced pluripotent stem cells (iPSCs) opening new avenues for cellular reprogramming and regenerative medicine [3][8] - The potential applications of reprogrammed cells from human waste, such as urine, into pluripotent stem cells could significantly impact the treatment of neurodegenerative diseases [8][9] - Establishing standardized clinical-grade stem cell resource banks is essential for the sustainable development of the industry, necessitating advancements in both technology and ethical regulations [8][9] Group 4 - The future of precision medicine lies in the organic combination of technological integration and innovative breakthroughs, shifting the focus from disease confrontation to quality of life management [9][10] - The aging population and chronic diseases are becoming major challenges in human health, necessitating support from policies, capital patience, and public understanding to promote precision medicine as a new pillar of health [9][10] - The "Good Hope Science Salon" aims to bridge the gap between academia and industry, fostering cross-disciplinary exchanges to explore new paradigms and pathways for technological innovation [10]

Group 1 - The core theme of the 2025 Customer Service Festival is "Accompanying with Qianhai, '10' is like 'YI'", emphasizing a customer-centric service philosophy through innovative online and offline integration [1] - The festival has evolved over ten years, consistently focusing on enhancing service quality and deepening service connotations [1] Group 2 - The "Yilu Xiangban" activity focuses on social responsibility, providing health knowledge and life enjoyment for elderly clients through traditional Chinese medicine lectures and hands-on activities [2] - Financial literacy and risk awareness are promoted through offline public education activities, helping clients safeguard their wealth [2] Group 3 - The "Yiqu Xingtong" offline activities include outdoor sports and museum study projects, allowing clients to experience traditional culture and enhance social interaction [3] - The "Walk into Medical Care" experience offers clients a chance to visit Qianhai's hospitals, showcasing the company's integrated model of insurance, healthcare, and elderly care [3] - The festival features a live-streaming health lecture series in collaboration with medical experts, providing clients with accessible health knowledge [3] - The "Yixin Shouhu" online activities enhance customer engagement through task completion for points and prizes, with an upgraded points mall for redeeming gifts [3] - The festival serves as a bridge for emotional connection between the company and its clients, aiming to provide a comprehensive and diverse service experience [3]

Group 1 - The spokesperson from the county housing construction bureau confirmed that the Tianxiayuan and Shuixiemingju residential projects are in the process of selecting homes, with Shuixiemingju expected to start selection in early July [1] - Tianxiayuan is located east of the Yingbin vegetable market, while Shuixiemingju is situated west of the Diyi International [5] Group 2 - The county medical insurance bureau spokesperson provided information on the necessary documents for applying for medical assistance, including identification and medical records [9] - The county urban management bureau acknowledged the issue with the public bicycle station at Baisheng Huayuan and stated that they are working to restore power to the station [9] - The county education bureau clarified that student class assignments are managed by the school, and parents can submit written requests for special considerations [9] Group 3 - The county housing provident fund spokesperson indicated that individuals who have repaid their housing provident fund loans can apply for new loans for improved housing, which will be subject to second-home interest rates [10]